CYP2E1 RsaI/PstI Polymorphism and Liver Cancer Risk among East Asians: a Huge Review and Meta-analysis

Abstract

Published data on any association between the CYP2E1 RsaI/PstI (c1/c2) polymorphism and liver cancer risk among east Asians are inconclusive. The aim of this Human Genome Epidemiology (HuGE) review and metaanalysis was to derive a more precise estimation of the relationship. A literature search of Pubmed, Embase, Web of science and CBM databases from inception through July 2012 was conducted. Twelve case-control studies were included with a total of 1,552 liver cancer cases and 1,763 healthy controls. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association under five genetic models. When all the eligible studies were pooled into the meta-analysis, the results showed that the c2 allele and the c2 carrier (c2/c2 + c2/c1) of RsaI/PstI polymorphism were associated with decreased risk of liver cancer among east Asians (

Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis

“…In addition, we explored the source of heterogeneity, but Zhou et al did not perform any analyses for it [30]. For CYP2E1 rs2031920, our results contrasted with those of the meta-analysis by Tian et al which reported an association between rs2031920 and HCC susceptibility in East Asians [31]. Tian and colleagues' results may be false positive, because they included studies deviating from Hardy-Weinberg equilibrium and pooled overlapping data from the same research group.…”

Toxicological implications of mitochondrial localization of CYP2E1

“…The RsaI/PstI variant was associated with increased colorectal cancer risk, while there was no association with the DraI variant 124 . CYP2E1 RsaI/PstI polymorphisms may reduce the risk of respiratory cancer and liver cancer 125 . One potential reason for the lack of consistent findings with genetic polymorphisms is the complex regulation and inducibility of CYP2E1 by many endogenous and exogenous factors.…”

CYP2E1 Genetic Polymorphism with Dietary, Tobacco, Alcohol Habits, H. pylori Infection Status and Susceptibility to Stomach Cancer in Mizoram, India

“…Although many studies around the world have been carried out so far to examine the association of CYP2E1 polymorphism and various cancer risk including stomach cancer, the results are not consistent and ethnic differences has been reported (Wang et al, 2010;Ye et al, 2010;Balaji et al, 2011;Shahriary et al, 2012;Tian et al, 2012;Lakkakula et al, 2013). Few studies revealed a positive association between CYP2E1 RsaI polymorphism and stomach cancer risk Boccia et al, 2007).…”