CYP2E1 and GSTM1 gene polymorphisms, environmental factors, and the susceptibility to lung cancer

He, Qin; Wang, Lixin; Zhang, Jie; Lu, Feng; Gong, Weiwei; Pan, Jay; Zhong, Jieming; Hu, Ruying; Yu, Min

doi:10.1002/jcla.22403

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…Finally, 85 articles (19,604 cases and 23,710 controls) were kept (Fig. 1), of which 70 articles (16,131 cases and 19,696 controls) were about the relationship between GSTM1 and cancers [4,5,16,17,24–89] (Table 1); 49 articles (11,555 cases and 14,606 controls) were about the relationship between GSTT1 and cancers [4,5,16,24,25,27–31,33,34,36–39,41,42,44–49,51,52,56,58,60,61,63,65–68,70,74–76,79,80,82–85,87,88,90–93] (Table 2); and 31 articles (8518 cases and 9884 controls) were about GSTP1 and cancers [5,16,17,24,30,31,34,36,42,44,45,47,49,52,59,66,67,70,79,88,94–103] (Table 3) among smokers. Among these researches, 8 articles mentioned the classification of smoking levels (20 pack-year).…”

Section: Resultsmentioning

confidence: 99%

“…Based on the 70 reports on smoking, there Smoking Nonsmoking Drinking Non-drinking Smoking Nonsmoking Drinking Non-drinking Firigato [89] 2022 Deek [24] 2021 Mixed Avirmed [26] 2021 Tcheandjieu [28] 2020 Mixed Ritambhara [34] 2019 Caucasian Lung cancer Singh [29] 2019 Caucasian Nasopharyngeal cancer Rostami [30] 2019 Caucasian Chronic myeloid leukemia Yamashita [31] 2019 Asian Thekkepaurakkal [17] 2019 Caucasian Head and neck cancer Li [32] 2019 Asian Kalacas [33] 2019 He [35] 2018 Pan [41] 2014 Asian Silva [42] 2014 Wang [43] 2014 Asian Jiang [44] 2014 Asian Yamada [45] 2014 Kang [51] 2013 Asian García-González [52] 2012 Caucasian Gastric cancer Yao [53] 2012 Asian Chen [54] 2012 Asian Zhang [55] 2012 Asian Liu [56] 2012 Asian Rouissi [61] 2011 Caucasian Bladder cancer Li [57] 2011 Asian Du [58] 2011 Asian Ramzy [59] 2011 Caucasian Lung cancer Karageorgi [60] 2011 Caucasian Cervical cancer Zheng [62] 2010 Asian Fan [63] 2010 Asian Jin [64] 2010 Asian Souiden [68] Palma [67] 2010 Caucasian Cervical cancer Huang [69] 2009 Asian were 24 articles for lung cancer, 8 articles for bladder cancer, 6 articles for liver cancer, 5 articles for gastric cancer, 5 articles for cervical cancer, 5 articles for head and neck cancer, 2 articles for esophageal cancer, 2 articles for nasopharyngeal cancer, 2 articles for breast cancer, and 2 articles for prostate cancer; the other types of cancer were not conducted subgroup analysis due to no more than 1 articles involved. Among subgroup of ethnicities, 34 studies were from Caucasian, 30 studies were from Asian, and 6 studies were mixed.…”

Section: Gstm1 Gene Polymorphism Studies Among Smokers and Drinkersmentioning

confidence: 99%

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Effects of Glutathione S-Transferases (GSTM1, GSTT1 and GSTP1) gene variants in combination with smoking or drinking on cancers: A meta-analysis

Hu,

Li,

Huang

et al. 2024

Medicine

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Background: This meta-analysis aimed to systematically summarize the association between cancer risks and glutathione s-transferases (GSTs) among smokers and drinkers. Methods: Literature was searched through PubMed, Web of Science, CNKI, and WANFANG published from 2001 to 2022. Stata was used with fixed-effect model or random-effect model to calculate pooled odds ratios (ORs) and the 95% confidence interval (95% CI). Sensitivity and heterogeneity calculations were performed, and publication bias was analyzed by Begg and Egger’s test. Regression analysis was performed on the correlated variables about heterogeneity, and the false-positive report probabilities (FPRP) and the Bayesian False Discovery Probability (BFDP) were calculated to assess the confidence of a statistically significant association. Results: A total of 85 studies were eligible for GSTs and cancer with smoking status (19,604 cases and 23,710 controls), including 14 articles referring to drinking status (4409 cases and 5645 controls). GSTM1-null had significant associations with cancer risks (for smokers: OR = 1.347, 95% CI: 1.196–1.516, P < .001; for nonsmokers: OR = 1.423, 95% CI: 1.270–1.594, P < .001; for drinkers: OR = 1.748, 95% CI: 1.093–2.797, P = .02). GSTT1-null had significant associations with cancer risks (for smokers: OR = 1.356, 95% CI: 1.114–1.651, P = .002; for nonsmokers: OR = 1.103, 95% CI: 1.011–1.204, P = .028; for drinkers: OR = 1.423, 95% CI: 1.042–1.942, P = .026; for nondrinkers: OR = 1.458, 95% CI: 1.014–2.098, P = .042). Negative associations were found between GSTP1rs1695(AG + GG/AA) and cancer risks among nondrinkers (OR = 0.840, 95% CI: 0.711–0.985, P = .032). Conclusions: GSTM1-null and GSTT1-null might be related cancers in combination with smoking or drinking, and GSTP1rs1695 might be associated with cancers among drinkers.

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Section: Resultsmentioning

confidence: 99%

Section: Gstm1 Gene Polymorphism Studies Among Smokers and Drinkersmentioning

confidence: 99%

Effects of Glutathione S-Transferases (GSTM1, GSTT1 and GSTP1) gene variants in combination with smoking or drinking on cancers: A meta-analysis

Hu,

Li,

Huang

et al. 2024

Medicine

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“…Glutathione S-transferase M 1 ( GSTM1 ), involved in detoxification pathways, is related to lung cancer risk in an environment-dependent manner and modifies lung disease severity in CF as well [ 11 , 66 , 67 ]. Transforming growth factor beta 1 ( TGFβ1 ), associated with inflammation and lung cancer risk and the smoking-related differentially methylated gene Aryl-hydrocarbon receptor repressor ( AHRR ) are likewise modifiers of CF lung disease [ 11 , 65 , 68 , 69 ].…”

Section: Introductionmentioning

confidence: 99%

Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells

et al. 2021

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Cystic fibrosis (CF) is a monogenic disease, characterized by massive chronic lung inflammation. The observed variability in clinical phenotypes in monozygotic CF twins is likely associated with the extent of inflammation. This study sought to investigate inflammation-related aberrant DNA methylation in CF twins and to determine to what extent acquired methylation changes may be associated with lung cancer. Blood-based genome-wide DNA methylation analysis was performed to compare the DNA methylomes of monozygotic twins, from the European CF Twin and Sibling Study with various degrees of disease severity. Putatively inflammation-related and differentially methylated positions were selected from a large lung cancer case-control study and investigated in blood by targeted bisulphite next-generation-sequencing. An inflammation-related locus located in the Plakophilin-3 ( PKP3 ) gene was functionally analysed regarding promoter and enhancer activity in presence and absence of methylation using luciferase reporter assays. We confirmed in a unique cohort that monozygotic twins, even if clinically discordant, have only minor differences in global DNA methylation patterns and blood cell composition. Further, we determined the most differentially methylated positions, a high proportion of which are blood cell-type-specific, whereas others may be acquired and thus have potential relevance in the context of inflammation as lung cancer risk factors. We identified a sequence in the gene body of PKP3 which is hypermethylated in blood from CF twins with severe phenotype and highly variably methylated in lung cancer patients and controls, independent of known clinical parameters, and showed that this region exhibits methylation-dependent promoter activity in lung epithelial cells.

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“…Deletion of GSTM1 leads to loss of the enzyme's ability to detoxify carcinogens. Individuals with deficient-type GSTM1 are more likely to develop cancer, including lung cancer [13][14][15] . There is a synergistic effect between GSTM1 and smoking in lung cancer [15][16][17] .…”

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confidence: 99%

Association of genetic polymorphisms of GSTM1 and smoking status with lung cancer risk*

Zhang

Wang

et al. 2019

Oncology and Translational Medicine

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ObjectiveLong-term cigarette smoke exposure damages the airway epithelium. However, the correlation among GSTM1 gene polymorphism, smoking status, and lung cancer susceptibility remains unclear. This study aimed to identify the genetic polymorphism of GSTM1 and examine the association of GSTM1 polymorphism and smoking history with lung cancer susceptibility.MethodsThe genetic polymorphism of GSTM1 was genotyped by polymerase chain reaction (PCR) in 217 lung cancer patients and 198 controls. The demographic data and smoking history of the patients were collected. The age, sex, and residence of the two groups were also obtained.ResultsSignificant differences in GSTM1 polymorphism were observed between the case and control groups (P = 0.024). Smoking time and smoking index were significantly different between the case and control groups. With the increase in smoking time and smoking index, the differences became more obvious. There was a synergistic effect between GSTM1 and smoking (S = 3.35). The risk of developing lung cancer increased 4.82 fold in smokers carrying deficient-type GSTM1. Compared with patients carrying wild-type GSTM1, the risk of developing lung cancer was higher in those carrying deficient-type GSTM1 with the increase in smoking time and smoking index. In different pathological types, no significant differences were observed in GSTM1 polymorphism. In different pathological types, the proportions of patients increased with the increase in smoking time and smoking index, especially the proportion of patients with squamous cell carcinoma. Compared with wild-type GSTM1, the proportion of patients with deficient-type GSTM1 increased with the increase in smoking time and smoking index (P = 0.003 and 0.017). This trend was mainly observed in those with squamous cell carcinoma.ConclusionGSTM1 mutation is associated with lung cancer susceptibility. Smokers carrying deficient-type GSTM1 are more likely to develop lung cancer. Compared with patients carrying wild-type GSTM1, smokers with deficient-type GSTM1 are more likely develop lung cancer when smoking time is more than 30 years and smoking index is more than 400. In patients carrying deficient-type GSTM1, the risk of developing squamous cell carcinoma increases with an increase in smoking time and smoking dose.

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CYP2E1 and GSTM1 gene polymorphisms, environmental factors, and the susceptibility to lung cancer

Cited by 7 publications

References 20 publications

Effects of Glutathione S-Transferases (GSTM1, GSTT1 and GSTP1) gene variants in combination with smoking or drinking on cancers: A meta-analysis

Effects of Glutathione S-Transferases (GSTM1, GSTT1 and GSTP1) gene variants in combination with smoking or drinking on cancers: A meta-analysis

Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells

Association of genetic polymorphisms of GSTM1 and smoking status with lung cancer risk*

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