Abstract:A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : The CYP2D6 enz yme shows a wi de ran ge of poly morp hisms. It is respon sib le for the me ta bo lism of subs tan ces such as opi a tes that ha ve a gre at im por tan ce in fo rensic sci en ces. Ho we ver, so me mu ta ti ons da ma ge the ac ti vity of this enz yme and ca u se in ter rup ti on in me ta bo lism of the drugs which may le ad to unex pec ted ad ver se drug re ac ti ons, even to de ath. Alt ho ugh many stu di es ha ve de alt with CYP2D6 pol… Show more
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