CYP2D6 Polymorphism and Parkinson's disease susceptibility

Sabbagh, N; Brice, Alexis; Marez, Delphine; Dürr, Alexandra; Legrand, M.; Guidice, Jean‐Marc Lo; Destée, Alain; Agid, Yves; Broly, Franck

doi:10.1002/1531-8257(199903)14:2<230::aid-mds1005>3.0.co;2-6

Cited by 17 publications

(6 citation statements)

References 35 publications

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“…Several studies have revealed a positive association of the poor metaboliser CYP2D6 genotype with an increased risk of sporadic PD (Armstrong et al 1992 ;Agundez et al 1995), whereas other studies have failed to replicate these findings (Bordet et al 1994 ;Diederich et al 1996 ;Gasser et al 1996). The two most recent studies (Ho et al 1999 ;Sabbagh et al 1999) found no evidence for an association between CYP2D6 and PD, suggesting that the CYP2D6 locus is not a major genetic determinant of the disease. Other genes have been studied, but the results so far are either conflicting, negative, or await further confirmation.…”

Section: Detoxification Enzymes and Pdmentioning

confidence: 99%

Genetics of Parkinsonism: a review

VAUGHAN¹,

DAVIS²,

WOOD³

2001

Annals of Human Genetics

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Idiopathic Parkinson's disease (IPD), a progressive neurodegenerative disorder, is a common cause of disability. No current therapies modify disease progression. The pathological hallmarks are the presence of Lewy bodies and massive loss of dopaminergic neurons in the pars compacta of the substantia nigra. Two genes (SNCA and parkin) as well as two gene loci have now been implicated in the pathogenesis of familial PD. These represent significant progress in our understanding of the disease, considering the rarity of large families, low heritability in the general population and genetic heterogeneity. Mutations in a further gene, UCHL1, have been described in familial PD although the evidence for its role in PD is less clear. Knowledge of the genes described in PD to date should help to define molecular mechanisms of neurodegeneration in PD, as well as in other diseases where defects in protein handling may be a common feature. Nigral degeneration with Lewy body formation and the resulting clinical picture of PD may represent a final common pathway of a multifactorial disease process in which both environmental and genetic factors have a role. This review discusses the major advances in the field to date and illustrates how the existence of genetic factors has now become firmly established.

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Section: Detoxification Enzymes and Pdmentioning

confidence: 99%

Genetics of Parkinsonism: a review

VAUGHAN¹,

DAVIS²,

WOOD³

2001

Annals of Human Genetics

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“…Volumetric abnormalities have also been associated with the basal ganglia and in turn with attention deficit hyperactivity disorder (ADHD). Qiu and colleagues [101], to specify localization of these abnormalities, employed large deformation diffeomorphic metric mapping (LDDMM) to examine the effects of ADHD, sex, and their interaction on basal ganglia shapes. The basal ganglia (caudate, putamen, globus pallidus) were manually delineated on magnetic resonance imaging from typically developing children and children with ADHD.…”

Section: Basal Ganglia In Adhdmentioning

confidence: 99%

Basal Ganglia - An Integrative View

Barrios¹,

Bauer²

2013

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“…A small population of PD cases is caused by genetic abnormalities, involving alpha-synuclein (Polymeropoulos et al, 1997;Papadimitrior et al, 1999and Kruger et al,1998, Dauer et al, 2002, ubiquitin (Leroy et al, 1998) and apolipoprotein E (APOE), (Kruger et al, 1999). Changes in chromosome 2p13 (Gasser et al, 1998), cyp2D6 (Kruger et al, 1999;Christensen et al, 1998;Kosel et al, 1996;Bon et al, 1999, Sabbagh et al, 1999 as well as mitochondria tRNA (A4336G) (Epensperger et al, 1997) have also been reported. The mutation of the parkin gene is closely associated with juvenile PD (Kitada et al, 1998), which has about eight variants (Lansbury and Brice, 2002).…”

Section: Major Symptoms and The Proposed Causes For Parkinson's Diseasementioning

confidence: 99%

Fetal and Environmental Basis for the Cause of Parkinson’s Disease

Charlton¹

2013

Basal Ganglia - An Integrative View

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CYP2D6 Polymorphism and Parkinson's disease susceptibility

Cited by 17 publications

References 35 publications

Genetics of Parkinsonism: a review

Genetics of Parkinsonism: a review

Basal Ganglia - An Integrative View

Fetal and Environmental Basis for the Cause of Parkinson’s Disease

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