CYP2D6 phenotypes among Malays in Malaysia

Ismail, Rusli; Hussein, Adil; Teh, Lay Kek; Isa, Mohd Nizam

doi:10.1046/j.1365-2710.2000.00304.x

Cited by 6 publications

(1 citation statement)

References 14 publications

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“…the extensive (EM) and the poor metabolizer (PM) phenotype – debrisoquine hydroxylation was assessed in the majority of human phenotyping studies [15, 16]. Family studies have shown that poor metabolizers are homozygous for an autosomal recessive allele, whereas the group of extensive metabolizers compromises heterozygotes and homozygous dominants [9, 17, 18].…”

Section: Introductionmentioning

confidence: 99%

Altered Distribution of the Debrisoquine Oxidative Phenotypes in Children with Type 1 Diabetes mellitus

Madácsy

Barkai²,

Sánta³

et al. 2004

Horm Res Paediatr

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Objective: The recently observed increase in the incidence of type 1 diabetes mellitus (Type 1 DM) suggests a major role of environmental factors in the etiopathogenesis of the disease. The individual variation in cytochrome P₄₅₀IID6 may influence the individual susceptibility to environmentally linked diseases. We aimed to evaluate the prevalence of cytochrome P₄₅₀IID6 phenotypes in Hungarian children with Type 1 DM (n = 69) compared to healthy controls (n = 100). Methods: Debrisoquine was administered orally and debrisoquine hydroxylation phenotype was determined as a metabolic ratio of urinary recovered debrisoquine and 4-hydroxydebrisoquine. Results: Eight of the 100 healthy subjects (8%) and 15 of the 69 diabetic children (22%) (p < 0.05) had cytochrome P₄₅₀IID6 poor metabolizer phenotype (metabolic ratio ≧12.6). Conclusion: Cytochrome P₄₅₀IID6’s activity may play a role in the development of Type 1 DM.

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Section: Introductionmentioning

confidence: 99%

Altered Distribution of the Debrisoquine Oxidative Phenotypes in Children with Type 1 Diabetes mellitus

Madácsy

Barkai²,

Sánta³

et al. 2004

Horm Res Paediatr

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Dextromethorphan metabolic phenotyping in an Iranian population

Afshar

Rouini

Ala

2005

Eur J Clin Pharmacol

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Heterogeneity of the CYP2D6 gene among Malays in Malaysia

Teh¹,

Ismail²,

Yusoff³

et al. 2001

J Clin Pharm Ther

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The genetic polymorphism of CYP2D6 in Malays is different from Chinese and Far Eastern races. They may be intermediate between East Asians and Caucasians in CYP2D6 activity. Further study in relation to the evolution of races and disease prevalence may help to identify the contributions of the polymorphism in alleged susceptibility to diseases apart from delineating its contributions to ethnic differences in the pharmacology of CYP2D6 drugs.

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CYP2D6 phenotypes among Malays in Malaysia

Cited by 6 publications

References 14 publications

Altered Distribution of the Debrisoquine Oxidative Phenotypes in Children with Type 1 Diabetes mellitus

Altered Distribution of the Debrisoquine Oxidative Phenotypes in Children with Type 1 Diabetes mellitus

Dextromethorphan metabolic phenotyping in an Iranian population

Heterogeneity of the CYP2D6 gene among Malays in Malaysia

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