CYP1A1 genotypes and haplotypes and risk of oral cancer: a case-control study in South Indians

Abstract

The CYP1A1 gene encodes for the enzyme, aryl hydrocarbon hydroxylase, which is involved in the biotransformation of various aromatic tobacco precarcinogens. In the present study, the association between CYP1A1 gene polymorphisms (IVS1-728G > A, Thr461Asn and Ile462Val), and the risk of oral cancer, was examined among 157 patients with oral cancer and 132 age-matched controls, in a south Indian population. The strength of the association between CYP1A1 variants and oral cancer was estimated by logistic regression. It was found that Thr461Asn was not polymorphic. Both IVS1-728G > A and Ile462Val frequencies were consistent with Hardy-Weinberg equilibrium in the control group. There were no significant differences in genotype or haplotype frequencies between controls and cases with oral cancer. Hence, CYP1A1 SNPs can be considered as not being associated with oral cancer at either the genotype or haplotype levels in the population studied.

Genetic Polymorphisms of the Human Cytochrome P450 1A1 (CYP1A1) and Cervical Cancer Susceptibility among Northeast Thai Women

“…Ordinary, m1 and m3 are located in the 3' noncoding region, giving rise to a MspI restriction site; whereas m2 and m4 are located in exon 7, leading to the amino acid transition of isoleucine to valine on codon 462 and threonine to asparagine on codon 461, respectively (Li et al, 2004). To date, genetic polymorphisms of human CYP1A1 have been widely studied for the susceptibility to various cancers (e.g., cancer of lung, oral, larynx, breast, thyroid, prostate, renal, cervix uteri, gastric, and colon) (Li et al, 2004;Gajecka et al, 2005;Little et al, 2006;Siraj et al, 2008;Wright et al, 2010;Li et al, 2016;Balaji et al, 2012;Agudo et al, 2014;Meng et al, 2015). Notwithstanding, to our knowledge there are no recent reports of any association between the four polymorphic loci of the CYP1A1 and cervical cancer susceptibility (Sugawara et al, 2003;Juárez-Cedillo et al, 2007;Gutman et al, 2009;Roszak et al, 2014;Abbas et al, 2014;Tan et al, 2016;Jain et al, 2017).…”

“…The TaqMan ® probe with primers (Applied Biosystems, USA) was designed for a specific SNP (viz., SNP assay: C_25624888_50). The respective FAM and VIC fluorescence dyes on the probes were used for the wild type (A allele) and the mutant type (G allele) (Balaji et al, 2012).…”

Association between CYP1A1 Ile462Val Polymorphism and Oral Squamous Cell Carcinoma Susceptibility: Evidence from 13 Investigations

“…And two studies were excluded as they were concerned of prognosis and only contained the cases, lacking of controls. Finally, 13 papers 20 - 24 , 35 - 42 were conformed to the inclusion criteria and they were eligible for the meta-analysis of CYP1A1 Ile462Val polymorphism.…”

The association of the CYP1A1 Ile462Val polymorphism with head and neck cancer risk: evidence based on a cumulative meta-analysis

“…Together, these observations indicate that current data describing the association between the CYP1A1 Ile462Val polymorphism and the risk of HNC are not entirely reliable. Three recent studies 41 , 43 , 44 on this topic have been subsequently published; however, further verification of the association between the CYP1A1 Ile462Val polymorphism and the risk of HNC is still required. The cumulative meta-analysis reported here was conducted to verify the association of the CYP1A1 Ile462Val polymorphism with the risk of HNC using data from a total of 34 studies that evaluated 6,367 cases and 6,395 controls.…”