CYP1A1 gene (6235T<C) polymorphism as a risk factor for polycystic ovarian syndrome among Egyptian women

Genetic Variants of CYP11B2 and CYP1A1 Among the North-Indian Punjabi Females with Polycystic Ovary Syndrome

“…In a meta-analysis conclusion was drawn in favor of rs4646903 polymorphism of CYP1A1, which after critical analysis provided a strong evidence of the genetic variant with susceptibility to PCOS[11]. The comparison with other studies is illustrated in Table 6[33][34][35][36][37][38].In conclusion, CYP11B2 and CYP1A1 play a crucial role in conversion of enzymes in steroidogenic pathway and disturbances in this pathway can lead to hyperandrogenism in females, which is a hallmark feature of PCOS. The case-control association analysis is suggestive of genetic predisposition of steroidogenic genes among PCOS patients in the North-Indian Punjabi females.…”