CYP19 gene rs2414096 variant and differential genetic risk of polycystic ovary syndrome: a systematic review and meta-analysis

Sharma, Priya; Kaur, Mandeep; Khetarpal, Preeti

doi:10.1080/09513590.2020.1813274

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…The effect of nutritional status on Vaspin levels that he observed in nonPCOS women was subsequently eliminated, possibly due to more severe insulin resistance. Sharma P discussed the relationship between the VDR gene and the polymorphisms of AMH and AMHR2 genes (Apa1, Bsm1, Fok1, and Cdx2) and their influence on the levels of AMH and 25(OH)D in women with PCOS [ 17 ]. In the end, his experimental results of VDR Cdx2 polymorphism analysis showed that compared with the control group, the frequency of homozygous GG mutant genotypes in the PCOS group was significantly higher in the experimental group [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation Analysis of Vaspin Gene Polymorphisms and Polycystic Ovary Syndrome Based on Intelligent Medicine

Tang¹,

Huang²,

Pan³

2022

Computational Intelligence and Neuroscience

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Polycystic ovary syndrome (PCOS) is now a common gynecological endocrine disease, also known as Stein–Leventhal syndrome. Studies have found that Vaspin gene polymorphism is significantly associated with diabetes and cardiovascular disease, and PCOS has a clear glucose metabolism abnormality. So far, because the cause of PCOS is not clear, many problems such as the etiology, diagnostic criteria, prevention, and treatment of PCOS remain unsolved. Which also makes PCOS attract the attention of academic circles. Therefore, it is urgent to clarify the pathogenesis of PCOS, in order to explore the clinical correlation between the polymorphism of the Vaspin gene and polycystic ovary syndrome. This article introduces the correlation analysis study of Vaspin gene polymorphisms and polycystic ovary syndrome based on intelligent medicine. This article first selected 40 patients with PCOS as the experimental group and then selected 40 patients without PCOS as the control group. Secondly, through the detection methods of hs-CRP level detection and oil red O fat staining and passed two sets of control experiments. Finally, intelligent medical data analysis was used to analyze the location of the Vaspin gene in the experimental group and the control group. The final result showed that the correlation reached 75%.

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Section: Introductionmentioning

confidence: 99%

Correlation Analysis of Vaspin Gene Polymorphisms and Polycystic Ovary Syndrome Based on Intelligent Medicine

Tang¹,

Huang²,

Pan³

2022

Computational Intelligence and Neuroscience

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“…Only two studies have also been carried out in India wherein one study concluded that variants of CYP19 gene are significantly associated with PCOS 21 , whereas other study investigating the polymorphism of CYP19 did not reveal any evidence of the gene being involved in the etiology of PCOS 22 . Recently, a meta-analysis carried out Sharma et al 23 on 7 case control studies that included 1414 cases and 1276 controls concluded that rs2414096 polymorphism of CYP19 is associated with the risk of PCOS.…”

Section: Introductionmentioning

confidence: 99%

Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women

Ashraf

Rasool

Nabi

et al. 2021

Sci Rep

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Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder in pre-menopausal women having complex pathophysiology. Several candidate genes have been shown to have association with PCOS. CYP19 gene encodes a key steroidogenic enzyme involved in conversion of androgens into estrogens. Previous studies have reported contradictory results with regard to association of SNP rs2414096 in CYP19 gene with PCOS and hyperandrogenism in different ethnic populations. Present study was aimed to investigate the impact of SNP rs2414096 polymorphism of CYP19 gene on susceptibility of PCOS and hyperandrogenism in Kashmiri women. Further we also studied the genotypic-phenotypic association for various clinical and biochemical parameters of this polymorphism. Case control study. 394 PCOS cases diagnosed on the basis of Rotterdam criteria and age matched 306 healthy women. We found a significant differences in genotypic frequency (χ2 = 18.91, p < 0.05) as well as allele frequency (OR 0.63, CI 0.51–0.78, χ2 = 17.66, p < 0.05) between PCOS women and controls. The genotype–phenotype correlation analysis showed a significant difference in FG score (p = 0.047) and alopecia (p = 0.045) between the three genotypes. Also, the androgen excess markers like DHEAS (p < 0.001), Androstenedione (p < 0.001), Testosterone (p < 0.001) and FAI (p = 0.005) were significantly elevated in GG genotype and showed a significant difference in additive model in PCOS women. rs2414096 polymorphism of CYP19 gene is associated with the risk of PCOS as well as with clinical and biochemical markers of hyperandrogenism, hence suggesting its role in clinical manifestations of PCOS in Kashmiri women.

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“…However, some results are contradictory. A meta-analysis by Sharma et al showed that there was a significant association between the CYP19A1 rs2414096 gene polymorphisms and PCOS risk in non-Indian populations, while no association was found in Indian populations ( Sharma et al, 2021 ). However, our meta-analysis found no significant association between the CYP19A1 rs2414096 gene polymorphisms and PCOS risk under dominant model.…”

Section: Discussionmentioning

confidence: 99%

“…Single nucleotide polymorphisms (SNPs) might reveal functional changes caused by amino acid variation or gene expression regulation. Candidate gene investigations provide insight into different frequency distributions in healthy and diseased populations ( Douma et al, 2019 ); however, previous studies exploring the potential relationship between PCOS susceptibility and CYP17A1/CYP19A1/SHBG gene polymorphisms used statistically insufficient samples sizes and reported inconsistent findings ( Li et al, 2012 ; Liao and Cao, 2020 ; Li et al, 2021 ; Sharma et al, 2021 ). Thus, The search acronym (PICO) for our meta-analysis to elucidate the relationship between CYP17A1/CYP19A1/SHBG gene polymorphisms in both wild type and mutant type and PCOS susceptibility in general populations in a larger study cohort.…”

Section: Introductionmentioning

confidence: 99%

The Association of CYP17A1, CYP19A1, and SHBG Gene Polymorphisms in Polycystic Ovary Syndrome Susceptibility: A Systematic Review and Meta-Analysis

et al. 2022

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Objective: To elucidate the relationship between CYP17A1/CYP19A1/SHBG gene polymorphisms and PCOS susceptibility.Methods: We searched multiple databases from inception to December 2020 and meta analysis was conducted to elucidate the relationship between gene polymorphisms and PCOS risk.Results: 26 studies were included, comprising 4860 PCOS and 4043 controls. CYP17A1 rs743572 polymorphisms were found to be negatively associated with PCOS risk under dominant model (p = 0.017, OR = 0.83, 95%CI 0.72–0.97, I2 = 74.80%, Pheterogeneity = 0.000) in the general population while neither CYP19A1 rs2414096 polymorphisms (p = 0.578, OR = 0.87, 95%CI 0.54–1.41, I2 = 95.90%, Pheterogeneity = 0.000) nor SHBG rs6529 polymorphisms (p = 0.752, OR = 0.99, 95%CI 0.94–1.05, I2 = 60.90%, Pheterogeneity = 0.012) was associated with PCOS susceptibility under dominant model in the general population.Conclusion: CYP17A1 rs7435721 polymorphisms might be protective factors against PCOS in general populations.Systematic Review Registration: https://www.crd.york.ac.uk/prospero/#myprospero, identifier CRD4202122640.

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CYP19 gene rs2414096 variant and differential genetic risk of polycystic ovary syndrome: a systematic review and meta-analysis

Cited by 5 publications

References 23 publications

Correlation Analysis of Vaspin Gene Polymorphisms and Polycystic Ovary Syndrome Based on Intelligent Medicine

Correlation Analysis of Vaspin Gene Polymorphisms and Polycystic Ovary Syndrome Based on Intelligent Medicine

Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women

The Association of CYP17A1, CYP19A1, and SHBG Gene Polymorphisms in Polycystic Ovary Syndrome Susceptibility: A Systematic Review and Meta-Analysis

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