CYP1-Activation and Anticancer Properties of Synthetic Methoxylated Resveratrol Analogues
Ketan C. Ruparelia,
Keti Zeka,
Kenneth J. M. Beresford
et al.
Abstract:Naturally occurring stilbenoids, such as the (E)-stilbenoid resveratrol and the (Z)-stilbenoid combretastatin A4, have been considered as promising lead compounds for the development of anticancer drugs. The antitumour properties of stilbenoids are known to be modulated by cytochrome P450 enzymes CYP1A1 and CYP1B1, which contribute to extrahepatic phase I xenobiotic and drug metabolism. Thirty-four methyl ether analogues of resveratrol were synthesised, and their anticancer properties were assessed, using the … Show more
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