Cynomorium Songaricum may protect against spermatogenic damage caused by cyclophosphamide in SD rats

Han, Xing; Zhou, Ru; Wei, Zheng; Wang, Xitao; Mao, Shuyan; Li, Zhenbei; Hao, Lin; Chen, Bo; Zhang, Zhiguo; Cao, Yijuan; Yu, Dian-Jun; Pang, Kun; Han, Conghui

doi:10.2478/rrlm-2019-0031

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The authors speculated that the spermatogenesis‐enhancing effect of C. songaricum was by inducing the expression of GDNF in the rat Sertoli cells required to promote the proliferation of undifferentiated spermatogonial cells (Cao et al, ). The expression of these germ cell markers was recently detected at the protein levels and was found to be significantly increased in the testis of the infertile rat model treated with different concentrations of decoction of C. songaricum (Han et al, ).…”

Section: Cynomorium Songaricummentioning

confidence: 99%

Plants in the management of male infertility

Onuah

Singh

2020

Andrologia

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This review attempts to collate existing data and provide the perspectives for future studies on the effects of plants on the male gonads. For many of these medicinal plants such as Lepidium meyenii, Rupus coreanus, Tribulus terrestres, Panax ginseng, Petasites japonicas, Apium graveolens, Eurycoma longifólia, Pedalium murex, Corchorus depressus, Mucuna pruriens, Astragalus membranaceus, Nigella sativa, Crataegus monogyna, Fagara tessmannii, Phaleria macrocarpa, Anacyclus pyrethrum, Cynomorium songaricum and Morinda officinalis, the mechanism of actions of their active principles and crude extracts has been shown in both laboratory animals, in vitro, and human studies, and includes their antioxidant, anti‐inflammatory, spermatogenesis‐inducing, aphrodisiac, smooth muscle relaxing and androgenic properties. Several active chemical leads including glucosinolates, anthocyanins, protodioscin, ginsenosides, sesquiterpenes, phyto‐oestrogens, quassinoids, diosgenin, thymoquinone, proanthocyanidins and bajijiasu isolated from these plants are known to have target effects on the testis, but efforts have been limited in their application at the clinical level. There still appear to be many more extracts of medicinal plants that have not been characterised to determine the phytochemicals unique to them that have target effects on the gonads. Further, collaborative efforts at isolating pro‐drug candidates from medicinal plants for studies at the molecular, cellular and clinical level towards elucidating their mechanisms of action on the testes are therefore warranted in the light of the current male fertility crisis.

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Section: Cynomorium Songaricummentioning

confidence: 99%

Plants in the management of male infertility

Onuah

Singh

2020

Andrologia

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“…Glial Cell Line-derived Neurotrophic Factor (GDNF) production in testes of SD rats and undifferentiated spermatogonia proliferation stimulates, increases testosterone levels, and improves sperm motility [ 129 ]. Relieving sperm damage and serum testosterone levels are increased through the MAPK-3-mediated GDNF signaling pathway, thereby enhancing sperm motility [ 130 ].…”

Section: Pharmacologymentioning

confidence: 99%

Research Progress in Traditional Applications, Phytochemistry, Pharmacology, and Safety Evaluation of Cynomorium songaricum

Zhang,

Chen,

Han

et al. 2024

Molecules

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Cynomorium songaricum Rupr. (CSR) belongs to the family Cynomoriaceae. It is a perennial succulent parasitic herb with a reddish-brown coloration, predominantly submerged in sand and lacking chlorophyll. Traditionally, it has been used in ethnic medicine to treat various diseases, such as gastric ulcers, indigestion, bowel movements, and improving sexual function. To comprehensively collect CSR data, extensive literature searches were conducted using medical, ecological, and scientific databases such as Google Scholar, PubMed, Science Direct, Web of Science, and China National Knowledge Infrastructure (CNKI). This article summarizes and categorizes research on the uses, phytochemical characteristics, pharmacological activities, and toxicity of ethnic medicine, with the aim of establishing a solid foundation and proposing new avenues for exploring and developing potential applications of CSR. So far, a total of 98 compounds have been isolated and identified from CSR, including flavonoids, terpenes, steroids, and other compounds. It is worth noting that flavonoids and polysaccharides have significant antioxidant and anti-inflammatory properties. In addition, these compounds also show good application prospects in anti-tumor, antioxidant, anti-aging, anti-fatigue, anti-diabetes, and other aspects. Although extensive progress has been made in the basic research of CSR, further research is still needed to enhance the understanding of its mechanism of action and explore more unknown compounds. Our review indicates that CSR has broad prospects and deserves further research.

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Cynomorium Songaricum may protect against spermatogenic damage caused by cyclophosphamide in SD rats

Cited by 2 publications

References 21 publications

Plants in the management of male infertility

Plants in the management of male infertility

Research Progress in Traditional Applications, Phytochemistry, Pharmacology, and Safety Evaluation of Cynomorium songaricum

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