Cynomorium songaricum induces spermatogenesis with glial cell-derived neurotrophic factor (GDNF) enhancement in rat testes

Yang, Woong Mο; Kim, Ha Young; Park, Soo Yeon; Kim, Hyung-Min; Chang, Mun Seog; Park, Seong Kyu

doi:10.1016/j.jep.2010.02.020

Cited by 35 publications

(35 citation statements)

References 13 publications

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“…Chemical components identified in CS extracts include organic acids, triterpenes, flavonoids, polysaccharide, and steroidal compounds [14–16]. A recent report described the potent effect of CS extracts on promoting spermatogenesis in rat testes as mediated through glial cell-derived neurotrophic factor (GDNF) stimulation, supporting the traditional utilization of CS for male sexual dysfunction [17]. CS extracts might also have estrogenic activities for female reproductive tissues that would alleviate menopausal symptoms and play a regulatory role on stimulating osteoblast proliferation to prevent further bone loss in osteoporosis [18, 19].…”

Section: Introductionmentioning

confidence: 99%

The Yang-Tonifying Herbal MedicineCynomorium songaricumExtends Lifespan and Delays Aging inDrosophila

Liu

Chang

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Aging is highly correlated with the progressive loss of physiological function, including cognitive behavior and reproductive capacity, as well as an increased susceptibility to diseases; therefore, slowing age-related degeneration could greatly contribute to human health. Cynomorium songaricum Rupr. (CS) is traditionally used to improve sexual function and treat kidney dysfunction in traditional Chinese medicine, although little is known about whether CS has effects on longevity. Here, we show that CS supplementation in the diet extends both the mean and maximum lifespan of adult female flies. The increase in lifespan with CS was correlated with higher resistance to oxidative stress and starvation and lower lipid hydroperoxides (LPO) levels. Additionally, the lifespan extension was accompanied by beneficial effects, such as improved mating readiness, increased fecundity, and suppression of age-related learning impairment in aged flies. These findings demonstrate the important antiaging effects of CS and indicate the potential applicability of dietary intervention with CS to enhance health and prevent multiple age-related diseases.

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Section: Introductionmentioning

confidence: 99%

The Yang-Tonifying Herbal MedicineCynomorium songaricumExtends Lifespan and Delays Aging inDrosophila

Liu

Chang

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…Moreover, parts of the plant are edible, and hence not particularly toxic to humans. Yet at the same time, various products derived from it are biologically active, and have been used for centuries to treat common disorders, as they show certain antiemetic, aphrodisiac and hypotensive activities [8][9][10]. Furthermore, we have recently reported some aspects of the active compounds found in this plant and possible mode(s) of action associated with them [7].…”

Section: Introductionmentioning

confidence: 93%

Nanosizing Cynomorium: Thumbs up for Potential Antifungal Applications

et al. 2017

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Cynomorium coccineum L., the desert thumb, is a rather exotic, parasitic plant unable to engage in photosynthesis, yet rich in a variety of unique compounds with a wide spectrum of biological applications. Whilst extraction, separation and isolation of such compounds is time consuming, the particular properties of the plant, such as dryness, hardness and lack of chlorophyll, render it a prime target for possible nanosizing. The entire plant, the external layer (coat) as well as its peel, are readily milled and high pressure homogenized to yield small, mostly uniform spherical particles with diameters in the range of 300 to 600 nm. The best quality of particles is obtained for the processed entire plant. Based on initial screens for biological activity, it seems that these particles are particularly active against the pathogenic fungus Candida albicans, whilst no activity could be observed against the model nematode Steinernema feltiae. This activity is particularly pronounced in the case of the external layer, whilst the peeled part does not seem to inhibit growth of C. albicans. Thanks to the ease of sample preparation, the good quality of the nanosuspension obtained, and the interesting activity of this natural product, nanosized coats of Cynomorium may well provide a lead for future development and applications as "green" materials in the field of medicine, but also environmentally, for instance in agriculture.

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“…The pharmaceutical and ethnobotanical properties of Maltese Mushroom are also known and were recorded centuries ago. As even reported in the Bible [Duke, 2008], it has been utilized in antihemorrhoidal, aphrodisiac, hypotensive, antiemetic, and antitumor applications and in the stimulation of spermatogenesis [Dharmananda, 2011;Wang et al, 2010;Yang et al, 2010;Yu et al, 2010]. During famines, it was eaten by humans, and it is currently used in herbal infusions and other food preparations [Cui et al, 2013;Jin et al, 2014].…”

Section: Introductionmentioning

confidence: 99%

Biological Activities and Nutraceutical Potentials of Water Extracts from Different Parts of Cynomorium coccineum L. (Maltese Mushroom)

Zucca¹,

Argiolas²,

Nieddu³

et al. 2016

Pol. J. Food Nutr. Sci.

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Maltese Mushroom (Cynomorium coccineum L.) is a non-photosynthetic plant that has been used in traditional medicine for many centuries. In this paper, water extracts from the whole plant, external layer and peeled plant were studied to determine the main components responsible for its biological activities, i.e., its antimicrobial, antioxidant, and anti-tyrosinase activities; its cytotoxicity against mouse melanoma B16F10 cells; and its pro-erectile activity in adult male rats. The results of electron transfer and hydrogen transfer assays showed that the antioxidant activity was mainly due to anthocyanins in the external layer, whereas the external layer and peeled plant extracts both inhibited the microbial growth of several Gram-positive strains. In contrast, the whole plant extract had the highest anti-tyrosinase activity and exhibited pro-erectile activity when administered subcutaneously. Overall, this study elucidated which parts of Maltese Mushroom are responsible for its antimicrobial, antioxidant, and anti-tyrosinase activities and thus which extracts have potential for use in nutraceutical formulations.

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Cynomorium songaricum induces spermatogenesis with glial cell-derived neurotrophic factor (GDNF) enhancement in rat testes

Cited by 35 publications

References 13 publications

The Yang-Tonifying Herbal MedicineCynomorium songaricumExtends Lifespan and Delays Aging inDrosophila

The Yang-Tonifying Herbal MedicineCynomorium songaricumExtends Lifespan and Delays Aging inDrosophila

Nanosizing Cynomorium: Thumbs up for Potential Antifungal Applications

Biological Activities and Nutraceutical Potentials of Water Extracts from Different Parts of Cynomorium coccineum L. (Maltese Mushroom)

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