Cynanchum bungei Decne and its two related species for “Baishouwu”: A review on traditional uses, phytochemistry, and pharmacological activities

Chen, Wenhua; Zhang, Zhenzhen; Ban, Yanfei; Rahman, Khalid; Ye, Bing-zhu; Sun, Xiaolei; Tan, Hui-ying; Zheng, Xiaodong; Liu, Hongyan; Xu, Lisha; Yan, Bin; Han, Ting

doi:10.1016/j.jep.2019.112110

Cited by 29 publications

(14 citation statements)

References 77 publications

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“…Baishouwu is a traditional tonic that can boost the liver and kidney, enrich vital essence and blood, strengthen the bones and muscles, and benefit life essence based on the theory of TCM ( Chen et al, 2019 ). According to the phytochemical studies, acetophenones and C-21 steroidal glycosides are the major bioactive constituents of Baishouwu .…”

Section: Discussionmentioning

confidence: 99%

“…The network pharmacology technique was used to explore the underlying mechanisms of TCSG in the treatment of hepatic and renal fibrosis. There are 12 active ingredients identified in TCSG from Baishouwu according to the literature and our previous study by LC-Q/TOF-MS ( Wang et al, 2017 ; Chen et al, 2019 ). The details of the twelve active ingredients were shown in Supplementary Figure S1 .…”

Section: Methodsmentioning

confidence: 99%

“…Based on the theory of TCM, this herb exhibits medicinal properties, including nourishing the liver and kidney and enhancing immune function. Pharmacological studies reveal that Baishouwu shows remarkable hepatoprotective, anti-inflammatory, and antitumor bioactivities ( Jang et al, 2016 ; Li et al, 2018 ; Chen et al, 2019 ). The total C-21 steroidal glycosides (TCSG) are commonly accepted as one of the most bioactive ingredients separated from Baishouwu ( Chen et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…Pharmacological studies reveal that Baishouwu shows remarkable hepatoprotective, anti-inflammatory, and antitumor bioactivities ( Jang et al, 2016 ; Li et al, 2018 ; Chen et al, 2019 ). The total C-21 steroidal glycosides (TCSG) are commonly accepted as one of the most bioactive ingredients separated from Baishouwu ( Chen et al, 2019 ). Previously, we reported that TCSG from Baishouwu protected the liver against the damage of oxidative toxicity and inflammatory reactions ( Cui et al, 2019 ; Zhang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Total C-21 Steroidal Glycosides From Baishouwu Ameliorate Hepatic and Renal Fibrosis by Regulating IL-1β/MyD88 Inflammation Signaling

et al. 2021

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Fibrosis is a worldwide public health problem, which typically results from chronic diseases and often leads to organ malfunction. Chronic inflammation has been suggested to be the major trigger for fibrogenesis, yet mechanisms by which inflammatory signals drive fibrogenesis have not been fully elucidated. Total C-21 steroidal glycosides (TCSG) from Baishouwu are the main active components of the root of Cynanchum auriculatum Royle ex Wight, which exert hepatoprotective and anti-inflammation properties. In this study, we established a mouse model with the coexistence of hepatic and renal fibrosis and aimed to investigate the effects of TCSG from Baishouwu on fibrosis and explored the potential mechanisms. The results of biochemical and pathological examinations showed that TCSG from Baishouwu improved liver and kidney function and alleviated hepatic and renal fibrosis by reducing collagen and extracellular matrix deposition in bile duct ligation and unilateral ureteral occlusion (BDL&UUO) mice. According to network pharmacology analysis, the mechanisms underlying the effects of TCSG from Baishouwu on hepatic and renal fibrosis were associated with inflammatory response pathways, including “Signaling by interleukins”, “MAP kinase activation”, “MyD88 cascade initiated on plasma membrane”, and “Interleukin-1 family signaling”. Regression analysis and western blot results revealed that IL-1β/MyD88 inflammation signaling played an essential role in the anti-fibrotic effects of TCSG from Baishouwu. Further data displayed that TCSG from Baishouwu affected inflammatory response and extracellular matrix deposition via suppressing the activation of p38 MAPK/JNK and NF-κB p65 signaling cascades both in the liver and kidney of BDL&UUO mice. Thus, our findings suggest TCSG from Baishouwu as a natural regimen against hepatic and renal fibrosis and provide direct evidence that IL-1β/MyD88 signaling crucially contributes to hepatic and renal fibrosis and modulates liver-kidney crosstalk by maintaining tight control over inflammatory responses.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Total C-21 Steroidal Glycosides From Baishouwu Ameliorate Hepatic and Renal Fibrosis by Regulating IL-1β/MyD88 Inflammation Signaling

et al. 2021

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“…Among them, CA and CW are mainly distributed in China, Japan, and Korea; while CB is concentrated in China, such as Shandong, Henan, Hebei, and Gansu provinces [ 4 , 5 ]. Current study has unraveled that CA , CB and CW displayed high medicinal value, exactly as C 21 -steroids were found to exhibit strong anti-tumor activity mainly involving hepatoma, breast cancer, and human glioma; while acetophenones and crude extracts of three species were revealed to exert immunomodulatory, hepatoprotection, anti-inflammatory, and anti-depressant activities [ 6 ]. Moreover, planting CA was able to bring high economic benefits, as it could be processed into flower tea and starch to be applied to the food industry [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects

et al. 2021

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Cynanchum auriculatum Royle ex Wight. (CA), Cynanchum bungei Decne. (CB) and Cynanchum wilfordii (Maxim.) Hemsl. (CW) are three close species belonging to the Asclepiadaceous family, and their dry roots as the bioactive part have been revealed to exhibit anti-tumor, neuroprotection, organ protection, reducing liver lipid and blood lipid, immunomodulatory, anti-inflammatory, and other activities. Until 2021, phytochemistry investigations have uncovered 232 compounds isolated from three species, which could be classified into C21-steroids, acetophenones, terpenoids, and alkaloids. In this review, the morphology characteristics, species identification, and the relationship of botany, extraction, and the separation of chemical constituents, along with the molecular mechanism and pharmacokinetics of bioactive constituents of three species, are summarized for the first time, and their phytochemistry, pharmacology, and clinical safety are also updated. Moreover, the direction and limitation of current research on three species is also discussed.

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Three New Pregnanes Isolated from the Cynanchum auriculatum

Huang

Fan

Jin

et al. 2022

Chemistry & Biodiversity

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Three new compounds named cynansteroid A (1), cynansteroid B (2) and cynansteroid C (3), together with nine known C21‐steroidal pregnane sapogenins (4–12) were isolated from the hydrolytic extract of the roots of Cynanchum auriculatum. The structures of cynansteroid A–C (1–3) were ascertained via the detailed analysis of the HR‐ESI‐MS, 1D and 2D NMR, and the calculated and experimental ECD data of cynansteroid B (2). Compound 11 displayed moderate inhibitory activity toward Verticillium dahliae Kleb (IC50=37.15 μM), furthermore, compounds 11 and 12 showed significant inhibitory activity against Phomopsis sp. (IC50=16.49 μM and 17.62 μM, respectively).

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Cynanchum bungei Decne and its two related species for “Baishouwu”: A review on traditional uses, phytochemistry, and pharmacological activities

Cited by 29 publications

References 77 publications

Total C-21 Steroidal Glycosides From Baishouwu Ameliorate Hepatic and Renal Fibrosis by Regulating IL-1β/MyD88 Inflammation Signaling

Total C-21 Steroidal Glycosides From Baishouwu Ameliorate Hepatic and Renal Fibrosis by Regulating IL-1β/MyD88 Inflammation Signaling

Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects

Three New Pregnanes Isolated from the Cynanchum auriculatum

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