2022
DOI: 10.1007/s43032-022-00907-0
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Cylindrospermopsin Disrupts Estrous Cycle and Increases Spermatogenesis in Mice

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Cited by 3 publications
(8 citation statements)
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“…In this study, cyanotoxins like cylindrospermopsin and microcystins derived from some cyanobacteria were seen to act as endocrine disruptors. Cyanotoxins pose a potential risk to animal and human health and their toxicity can affect multiple organs, including the endocrine system [ 60 ] or the male and female reproductive systems [ 15 ].…”
Section: Discussionmentioning
confidence: 99%
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“…In this study, cyanotoxins like cylindrospermopsin and microcystins derived from some cyanobacteria were seen to act as endocrine disruptors. Cyanotoxins pose a potential risk to animal and human health and their toxicity can affect multiple organs, including the endocrine system [ 60 ] or the male and female reproductive systems [ 15 ].…”
Section: Discussionmentioning
confidence: 99%
“…In the mycotoxin class, the most extensively studied N-EDCs are alternariol and zearalenone, mycotoxins produced by the Alternaria genus [ 11 ] and Fusarium species, respectively, which can be ingested through food contamination and show endocrine-disrupting activity such as alterations of the male [ 12 ] and female reproductive system [ 13 ]. Several studies show that some cyanotoxins, secondary metabolites [ 14 ] produced by a variety of freshwater cyanobacteria, such as microcystins and cylindrospermopsin, can interfere with the endocrine system in mammals [ 15 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Conversely, pure CYN did show binding affinity to the estrogen receptor [113]. Although studies dealing with CYN are very limited, and the results obtained were also variable, it showed ED effects mediated by changes in the transcript levels of related hormones, apoptosis induction [114], changes in thyroid-hormone-related genes [116], oxidative stress [117], or alterations in hormone levels [114,115].…”
Section: General Discussion and Final Remarksmentioning
confidence: 99%
“…Finally, the disruption of the estrous cycle and its effects on spermatogenesis in vivo in female and male mice was recently investigated [115]. A single i.p.…”
Section: Cylindrospermopsinmentioning
confidence: 99%