Cylindrospermopsin Disrupts Estrous Cycle and Increases Spermatogenesis in Mice

Moraes, A.C.N.; Caires, Fernanda Oliveira Caires e; Império, Güínever E.; Nóbrega, Rafael Henrique; Ortiga-Carvalho, Tânia M.; Magalhães, Valéria Freitas de

doi:10.1007/s43032-022-00907-0

Cited by 3 publications

(8 citation statements)

References 38 publications

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“…In this study, cyanotoxins like cylindrospermopsin and microcystins derived from some cyanobacteria were seen to act as endocrine disruptors. Cyanotoxins pose a potential risk to animal and human health and their toxicity can affect multiple organs, including the endocrine system [ 60 ] or the male and female reproductive systems [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the mycotoxin class, the most extensively studied N-EDCs are alternariol and zearalenone, mycotoxins produced by the Alternaria genus [ 11 ] and Fusarium species, respectively, which can be ingested through food contamination and show endocrine-disrupting activity such as alterations of the male [ 12 ] and female reproductive system [ 13 ]. Several studies show that some cyanotoxins, secondary metabolites [ 14 ] produced by a variety of freshwater cyanobacteria, such as microcystins and cylindrospermopsin, can interfere with the endocrine system in mammals [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…The therapeutic use of many N-EDCs, combined with their toxicological effects (duplex effects), often results in controversial and confusing information. Few clinical or epidemiological results are available from humans, while a slightly higher number of toxicological findings are based on in vitro studies [ 8 , 19 , 20 , 21 ] and rodent [ 15 , 22 , 23 ] models. It is important to note that a substance may be an EDC for one species and not for another [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Virtuoso,

Raggi,

Maugliani

et al. 2024

Toxics

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Endocrine-disrupting compounds are chemicals that alter the normal functioning of the endocrine system of living organisms. They can be natural (N-EDCs) or synthetic compounds (S-EDCs). N-EDCs can belong to different groups, such as phytoestrogens (PEs), including flavonoids, or mycotoxins originating from plants or fungi, and cyanotoxins, derived from bacteria. Humans encounter these substances in their daily lives. The aim of this rapid review (RR) is to provide a fine mapping of N-EDCs and their toxicological effects on human health in terms of various medical conditions or adverse consequences. This work is based on an extensive literature search and follows a rigorous step-by-step approach (search strategy, analysis strategy and data extraction), to select eligible papers published between 2019 and 2023 in the PubMed database, and to define a set of aspects characterizing N-EDCs and the different human target systems. Of the N-EDCs identified in this RR, flavonoids are the most representative class. Male and female reproductive systems were the targets most affected by N-EDCs, followed by the endocrine, nervous, bone and cardiovascular systems. In addition, the perinatal, pubertal and pregnancy periods were found to be particularly susceptible to natural endocrine disruptors. Considering their current daily use, more toxicological research on N-EDCs is required.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Virtuoso,

Raggi,

Maugliani

et al. 2024

Toxics

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“…Conversely, pure CYN did show binding affinity to the estrogen receptor [113]. Although studies dealing with CYN are very limited, and the results obtained were also variable, it showed ED effects mediated by changes in the transcript levels of related hormones, apoptosis induction [114], changes in thyroid-hormone-related genes [116], oxidative stress [117], or alterations in hormone levels [114,115].…”

Section: General Discussion and Final Remarksmentioning

confidence: 99%

“…Finally, the disruption of the estrous cycle and its effects on spermatogenesis in vivo in female and male mice was recently investigated [115]. A single i.p.…”

Section: Cylindrospermopsinmentioning

confidence: 99%

Potential Endocrine Disruption of Cyanobacterial Toxins, Microcystins and Cylindrospermopsin: A Review

Casas-Rodríguez

Cameán

Jos

2022

Toxins

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Microcystins (MCs) and cylindrospermopsin (CYN), although classified as hepatotoxins and cytotoxins, respectively, have been shown to also induce toxic effects in many other systems and organs. Among them, their potential endocrine disruption (ED) activity has been scarcely investigated. Considering the increasing relevance of ED on humans, mammals, and aquatic organisms, this work aimed to review the state-of-the-art regarding the toxic effects of MCs and CYN at this level. It has been evidenced that MCs have been more extensively investigated than CYN. Reported results are contradictory, with the presence or absence of effects, but experimental conditions also vary to a great extent. In general, both toxins have shown ED activity mediated by very different mechanisms, such as estrogenic responses via a binding estrogen receptor (ER), pathological changes in several organs and cells (testis, ovarian cells), and a decreased gonad-somatic index. Moreover, toxic effects mediated by reactive oxygen species (ROS), changes in transcriptional responses on several endocrine axes and steroidogenesis-related genes, and changes in hormone levels have also been reported. Further research is required in a risk assessment frame because official protocols for assessment of endocrine disrupters have not been used. Moreover, the use of advanced techniques would aid in deciphering cyanotoxins dose-response relationships in relation to their ED potential.

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Cylindrospermopsin exposure promotes redox unbalance and tissue damage in the liver of Poecilia reticulata , a neotropical fish species

de Sabóia-Morais,

de Lima Faria,

da Silva Rabelo

et al. 2023

Journal of Toxicology and Environmental Health, Part A

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Cylindrospermopsin Disrupts Estrous Cycle and Increases Spermatogenesis in Mice

Cited by 3 publications

References 38 publications

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review

Potential Endocrine Disruption of Cyanobacterial Toxins, Microcystins and Cylindrospermopsin: A Review

Cylindrospermopsin exposure promotes redox unbalance and tissue damage in the liver of Poecilia reticulata , a neotropical fish species

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