Cylindroma and Eccrine Spiradenoma Coexistent in the Same Lesion

Goette, COL Detlef K.

doi:10.1001/archderm.1982.01650160063026

Cited by 49 publications

(12 citation statements)

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“…Occasionally, spiradenomas may exhibit cylindromatous features or mixed differentiation with foci of cylindroma present within the tumor, as in the case reported here 5–7 . Rare malignant transformation has been reported, usually in the setting of a previously benign eccrine spiradenoma 8 .…”

Section: Discussionmentioning

confidence: 67%

“…Therefore, the coexistence of trichoepitheliomas and cylindromas implies that cylindromas may be of apocrine origin 14 . However, the repeated occurrence of eccrine spiradenomas in patients with BSS and their coexistence in the same lesion with cylindromas, 6,7 “spiradenocylindroma”, 6 has called into question the eccrine origin of cylindromas.…”

Section: Discussionmentioning

confidence: 99%

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Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap

et al. 2005

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap

et al. 2005

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“…This finding of contiguous growth had prompted us to include tumours with mixed features of both cylindromas and spiradenomas. Spiradenocylindromas, a recognized feature in CYLD mutation carriers 2, have previously been suggested to represent a collision phenomenon, which is two adjacent tumours growing into each other 21. However, clinical observation of CYLD mutation carriers revealed that cylindroma tumours can become painful over time and that this is often associated with a change in colour of the tumour from pink to blue (N Rajan, unpublished observations), suggesting a spiradenoma focus developing within a pre‐existing cylindroma at least in some cases.…”

Section: Resultsmentioning

confidence: 99%

Transition from cylindroma to spiradenoma in CYLD‐defective tumours is associated with reduced DKK2 expression

Rajan

Burn

Langtry

et al. 2011

The Journal of Pathology

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Patients carrying heterozygous germline truncating mutations in the CYLD gene develop multiple primary hair follicle-related tumours. A highly patterned tumour, termed cylindroma, and a highly disorganized tumour, termed spiradenoma, may both develop in the same patient. Furthermore, histological features of both tumour types have been described within the same tumour specimen. We used three-dimensional computer-aided reconstruction of these tumours to demonstrate contiguous growth of cylindromas into spiradenomas, thus suggesting a transition between the two tumour types. To explore factors that may influence cutaneous tumour patterning, genome-wide transcriptomic analysis of 32 CYLD-defective tumours was performed. Overexpression of the Wnt/β-catenin signalling pathway was observed relative to normal perilesional tissue. Morphometric analysis was used to investigate the relationship between Wnt pathway-related gene expression and tumour organization. This revealed an association between reduced Dickkopf 2 (DKK2-a negative regulator of the Wnt/β-catenin signalling pathway) expression and loss of tumour patterning. Reduced DKK2 expression was associated with methylation of the DKK2 gene promoter in the majority of tumour samples assayed. RNA interference-mediated silencing of DKK2 expression in cylindroma primary cell cultures caused an increase in colony formation, cell viability, and anchorage-independent growth. Using these data, we propose a model where epigenetic programming may influence tumour patterning in patients with CYLD mutations.

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“…The rate of malignant transformation is very low. Spiradenomas also may occur in Brooke-Spiegler syndrome, which manifests with cylindromas, spiradenomas, and trichoepitheliomas 3–5. Most spiradenomas have been reported to arise in those aged 15–35.…”

Section: Discussionmentioning

confidence: 99%

Differential considerations of skin tumours with florid vascularisation: report of a solitary giant vascular eccrine spiradenoma

Trémezaygues

Pföhler²,

Vogt³

et al. 2011

Case Reports

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The authors report the case of an 81-year-old male who presented with a 3-year-history of a bluish, nodular tumour located on the extensor side of his right forearm. Subjective symptoms included tenderness upon palpation and spontaneous haemorrhage. In order to exclude malignant neoplasms, for example, nodular melanoma, metastatic melanoma or angiosarcoma, the tumour was surgically removed and tissue submitted for microscopic examination. Histologically, the authors diagnosed this as giant vascular eccrine spiradenoma, a rare variant of eccrine spiradenoma, which can easily be mistaken for angiomatous lesions due to the haemorrhagic features and florid vascularisation. It is our aim to help clarify the diagnosis and differentiate giant vascular eccrine spiradenoma from other painful cutaneous tumours exhibiting a high degree of vascularisation, for example, angiosarcoma or venous thrombosis, as this case represents one of only seven found in published literature.

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Cylindroma and Eccrine Spiradenoma Coexistent in the Same Lesion

Cited by 49 publications

References 0 publications

Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap

Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap

Transition from cylindroma to spiradenoma in CYLD‐defective tumours is associated with reduced DKK2 expression

Differential considerations of skin tumours with florid vascularisation: report of a solitary giant vascular eccrine spiradenoma

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