CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1

Douanne, Tiphaine; André-Grégoire, Gwennan; Thys, An; Trillet, Kilian; Gavard, Julie; Bidère, Nicolas

doi:10.1016/j.celrep.2019.04.036

Cited by 32 publications

(40 citation statements)

References 43 publications

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“…Cylindromatosis (CYLD) is a member of the USP family of proteins and is expressed in centriolar satellites [ 148 ]. CYLD stimulates ciliogenesis by stabilizing centrosomal protein 70 (CEP70) and pericentriolar material 1 (PCM1) [ 132 , 133 ]. Stabilization of PCM1 by CYLD is mediated by deubiquitination of mindbomb E3 ubiquitin protein ligase 1 (MIB1), which is activated by ubiquitination on lysine 63 [ 133 ].…”

Section: Roles Of E3 Ubiquitin Ligases and Dubs In Ciliogenesis Cmentioning

confidence: 99%

“…CYLD stimulates ciliogenesis by stabilizing centrosomal protein 70 (CEP70) and pericentriolar material 1 (PCM1) [ 132 , 133 ]. Stabilization of PCM1 by CYLD is mediated by deubiquitination of mindbomb E3 ubiquitin protein ligase 1 (MIB1), which is activated by ubiquitination on lysine 63 [ 133 ]. Lysine 63-ubiquitinated MIB1 then ubiquitinates PCM1 and stimulates its degradation in proteasomes.…”

Section: Roles Of E3 Ubiquitin Ligases and Dubs In Ciliogenesis Cmentioning

confidence: 99%

“…For example, homotypic K48 polyubiquitination is related to classical proteasomal degradation; homotypic K63 polyubiquitination regulates protein–protein interactions; homotypic K6 and K27 polyubiquitinations are involved in the DNA damage response; and homotypic K29 and K33 polyubiquitinations are linked to innate immunity. In centriolar satellites, which are electron-dense and spherical cytoplasmic granules around centrosomes, modification of the E3 ubiquitin ligase MIB1 by homotypic K63 polyubiquitination induces homotypic K48 polyubiquitination of its substrate PCM1, resulting in PCM1 proteasomal degradation [ 133 ]. PCM1 plays an indispensable role in the clustering of centriolar satellites around the centrosome to orchestrate ciliogenesis [ 174 ].…”

Section: Future Directionsmentioning

confidence: 99%

“…PCM1 plays an indispensable role in the clustering of centriolar satellites around the centrosome to orchestrate ciliogenesis [ 174 ]. CYLD located in centriolar satellites deubiquitinates the K63 polyubiquitin chain of MIB1, thereby antagonizing MIB1-mediated degradation of PCM1 and suppressing ciliogenesis [ 133 ]. Somatostatin receptor 3 (SSTR3) and G protein-coupled receptor 161 (GPR161) are important G protein-coupled receptors (GPCRs) that regulate somatostatin and hedgehog signaling, respectively, in primary cilia.…”

Section: Future Directionsmentioning

confidence: 99%

See 3 more Smart Citations

Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer

Shiromizu

Yuge

Kasahara

et al. 2020

IJMS

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Cilia are antenna-like structures present in many vertebrate cells. These organelles detect extracellular cues, transduce signals into the cell, and play an essential role in ensuring correct cell proliferation, migration, and differentiation in a spatiotemporal manner. Not surprisingly, dysregulation of cilia can cause various diseases, including cancer and ciliopathies, which are complex disorders caused by mutations in genes regulating ciliary function. The structure and function of cilia are dynamically regulated through various mechanisms, among which E3 ubiquitin ligases and deubiquitinases play crucial roles. These enzymes regulate the degradation and stabilization of ciliary proteins through the ubiquitin–proteasome system. In this review, we briefly highlight the role of cilia in ciliopathy and cancer; describe the roles of E3 ubiquitin ligases and deubiquitinases in ciliogenesis, ciliopathy, and cancer; and highlight some of the E3 ubiquitin ligases and deubiquitinases that are potential therapeutic targets for these disorders.

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Section: Roles Of E3 Ubiquitin Ligases and Dubs In Ciliogenesis Cmentioning

confidence: 99%

Section: Roles Of E3 Ubiquitin Ligases and Dubs In Ciliogenesis Cmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

See 2 more Smart Citations

Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer

Shiromizu

Yuge

Kasahara

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…For instance, Gao et al identified that, Cyld interacts with tubulins, and the activity of this DUB is required for microtubule assembly and maintaining its stability. Consequently, it is possible that Cyld is also necessary for several autophagic processes, which use vesicular trafficking mechanisms [ 83 , 97 , 98 , 99 , 100 ].…”

Section: The Activity Of Deubiquitinating Enzymes In Autophagic Mementioning

confidence: 99%

The Role of Deubiquitinating Enzymes in the Various Forms of Autophagy

Csizmadia

Lőw

2020

IJMS

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Deubiquitinating enzymes (DUBs) have an essential role in several cell biological processes via removing the various ubiquitin patterns as posttranslational modification forms from the target proteins. These enzymes also contribute to the normal cytoplasmic ubiquitin pool during the recycling of this molecule. Autophagy, a summary name of the lysosome dependent self-degradative processes, is necessary for maintaining normal cellular homeostatic equilibrium. Numerous forms of autophagy are known depending on how the cellular self-material is delivered into the lysosomal lumen. In this review we focus on the colorful role of DUBs in autophagic processes and discuss the mechanistic contribution of these molecules to normal cellular homeostasis via the possible regulation forms of autophagic mechanisms.

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Proteolytic control in ciliogenesis: Temporal restriction or early initiation?

Habeck

Schweiggert

2022

BioEssays

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Cellular processes are highly dependent on a dynamic proteome that undergoes structural and functional rearrangements to allow swift conversion between different cellular states. By inducing proteasomal degradation of inhibitory or stimulating factors, ubiquitylation is particularly well suited to trigger such transitions. One prominent example is the remodelling of the centrosome upon cell cycle exit, which is required for the formation of primary cilia – antenna‐like structures on the surface of most cells that act as integrative hubs for various extracellular signals. Over the last decade, many reports on ubiquitin‐related events involved in the regulation of ciliogenesis have emerged. Very often, these processes are considered to be initiated ad hoc, that is, directly before its effect on cilia biogenesis becomes evident. While such a temporal restriction may hold true for the majority of events, there is evidence that some of them are initiated earlier during the cell cycle. Here, we provide an overview of ubiquitin‐dependent processes in ciliogenesis and discuss available data that indicate such an early onset of proteolytic regulation within preceding cell cycle stages.

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CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1

Cited by 32 publications

References 43 publications

Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer

Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer

The Role of Deubiquitinating Enzymes in the Various Forms of Autophagy

Proteolytic control in ciliogenesis: Temporal restriction or early initiation?

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