Cyclotron production of 64Cu by deuteron irradiation of 64Zn

Development of a generic approach to native metalloproteomics: application to the quantitative identification of soluble copper proteins in Escherichia coli

“…A half-life of 12.5 ± 0.2 h was found for the 64 Cu stock solution, which is in a good agreement with the known half-life of 12.7 h [20] (Fig. S1).…”

New measurement and evaluation of the excitation function of 64Ni(p,n) reaction for the production of 64Cu

“…Among other suggested production pathways by charged particle activation, 64 Zn(d,2p) [6][7][8] and 64 Ni(d,2n) [9][10][11], the route 64 Ni(p,n) 64 Cu is presently the most widely used for practical applications. Although several studies on this proton induced reaction on enriched 64 Ni or natural nickel are available from literature, some of them present large discrepancies especially at energies of the protons higher than 8 MeV [12][13][14][15][16][17][18][19][20][21][22].…”

Fast 18F Labeling of a Near-Infrared Fluorophore Enables Positron Emission Tomography and Optical Imaging of Sentinel Lymph Nodes

“…Unfortunately, each of these PET nuclides presents intrinsic complications. For example, 64 Cu (3,4,8) and 68 Ga (9,10) chelates can suffer from impure isotope production as well as lowered specific activity because of impure isotope decay (11) and large chelation moieties that may alter ligand biodistribution and may also suffer from in vivo metal ion transchelation (12). Alternatively, traditional 18 F labeling methods (5,13−17) relying on C−F bond formation are water-sensitive, multistep processes that often require harsh reaction conditions and long processing times that are poorly suited to the short half-life of 18 F.…”