“…Psyle A -F U-937GTB, MCF-7, MCF-7/ADR 0.72 to >10 [51,52] Viola odorata CyO2 A549, ACHN, BEL-7402, BGC-823, BEL-7402, DU145, CCRF-CEM, CCRF-CEM/VM-1, CLL,NCI-H66, NCI-H69AR, MDA-MB-231, OVCA, PBMC, RPMI-8226/s, RPMI-8226/ Dox40, RPMI-8226/LR-5, U251, U-937GTB, U-937VcR 0.1 to 17.05 [45,49,52,55] V. abyssinica Vaby A U-937 GTB 7.6 [56] Vaby D A549, BEL-7402, BGC-823, DU145, MDA-MB-231, U251, U-937 GTB 2.8 to 46.62 [53,56] V. arvensis Varv A ACHN, CCRF-CEM, CCRF-CEM/VM-1, CLL,NCI-H66, NCI-H69AR, OVCA, PBMC, RPMI-8226/s, RPMI-8226/ Dox40, RPMI-8226/LR-5, U-937GTB, U-937VcR 2.7 to 12.1 [45] Varv F ACHN, CCRF-CEM, CCRF-CEM/VM-1, CLL,NCI-H66, NCI-H69AR, OVCA, PBMC, RPMI-8226/s, RPMI-8226/ Dox40, RPMI-8226/LR-5, U-937GTB, U-937VcR 2.6 to 7.4 [45] V. labridorica Vila A A549, BEL-7402, BGC-823, DU145, MDA-MS-123, U251 5.08 to >10 [49] Vila B A549, BEL-7402, BGC-823, DU145, MDA-MS-123, U251 6.25 to 34.65 [49] Vila D A549, BEL-7402, BGC-823, DU145, MDA-MS-123, U251 >10 to 49.59 [49] V. philippica Viphi A-G BGC-823, HeLa, HFF-1, MM96L 1.03 to 6.35 [55] Viba 15, 17, Varv A, Kalata B1 BGC-823, HeLa, HFF-1, MM96L 1.32 to 10.21 [55] V. tricolor Varv A,D, E, F, H, He, Hm RPMI-8226/s, U-937GTB 4 to 74.39 [46,54] Vitri A-F A549, BEL-7402, DU145, MDA-MB-231, RPMI-8226/s, U251, U-937GTB 0.6 to 54.39 [46,54] V. biflora Vibi D U-937GTB >30 [49] Vibi E U-937GTB 3.2 [49] Vibi G U-937GTB 1 [49] Vibi H U-937GTB 1.6 [49] A549 Two amino acid residues that can impact potency of several bioactivities are the conserved Glu in loop 1 and tryptophan (Trp, W). For instance, the esterification of Glu in the bracelet cyclotide, CyO 2 , results in a 48-fold decrease in cytotoxic potency [48] and a near loss of antibacterial activity against Salmonella sp.…”