Cyclothymic temperament as a prospective predictor of bipolarity and suicidality in children and adolescents with major depressive disorder

Kochman, F.; Hantouche, Elie G.; Ferrari, P.; Lancrenon, S.; Bayart, D.; Akiskal, Hagop S.

doi:10.1016/j.jad.2003.09.009

Cited by 226 publications

(164 citation statements)

References 32 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…Almost half of depressed children are reported to be bipolar and this outcome is more common in those with cyclothymic temperament measured at baseline. Bipolar children are characterized by rapid mood shifts with associated conduct disorders, aggressiveness, psychotic symptoms and suicidality 156 . More generally, it has been suggested that clinically ascertained juvenile depressions (with onsets typically in late childhood or early adolescence) are part of the bipolar spectrum disorders and are characterized by frequent superposition on affective temperamental dysregulation.…”

Section: Family History/geneticsmentioning

confidence: 99%

The Role of Temperament in the Etiopathogenesis of Bipolar Spectrum Illness

Fountoulakis

Gonda

Koufaki

et al. 2016

Harvard Review of Psychiatry

View full text Add to dashboard Cite

Bipolar disorder constitutes a challenge for clinicians in everyday clinical practice. Our knowledge concerning this clinical entity is incomplete and contemporary classification systems are unable to reflect the complexity of this disorder.. The concept of temperament which for the first time was described during antiquity constitutes a reasonable vehicle to synthesize our knowledge on how the human body works and what determines human behavior. Although it originally included philosophical and sociocultural approaches, today the biomedical model is dominant. It is possible that specific temperaments might constitute vulnerability factors, determine the clinical picture or constitute illness course modifiers and even act as a bridge between genes and clinical manifestations, thus giving birth to the concept of the bipolar spectrum with major implications for all aspects of mental health research and providing of care. More specifically it has been reported that the hyperthymic and the depressive temperaments are related to the more 'classic' bipolar disorder, while cyclothymic, anxious and irritable temperaments are related to more complex manifestations and might predict poor response to treatment, violent or suicidal behavior and high comorbidity. It seems reasonable to assume that the incorporating of the concept of temperament and the bipolar spectrum in the standard training of psychiatric residents might result in an improvement of everyday clinical practice.3

show abstract

Section: Family History/geneticsmentioning

confidence: 99%

The Role of Temperament in the Etiopathogenesis of Bipolar Spectrum Illness

Fountoulakis

Gonda

Koufaki

et al. 2016

Harvard Review of Psychiatry

View full text Add to dashboard Cite

show abstract

“…A 2-year prospective study in France examined 80 children and adolescents (7 -17 yrs) with DSM-IV major depressive disorder (Kochman et al, 2005). Of the 80, 35 (43%) converted to bipolar I or II disorder within 2 years.…”

Section: Longitudinal Studiesmentioning

confidence: 99%

Prevention of bipolar disorder in at-risk children: Theoretical assumptions and empirical foundations

Miklowitz

Chang

2008

Dev Psychopathol

View full text Add to dashboard Cite

This article examines how bipolar symptoms emerge during development, and the potential role of psychosocial and pharmacological interventions in the prevention of the onset of the disorder. Early signs of bipolarity can be observed among children of bipolar parents and often take the form of subsyndromal presentations (e.g., mood lability, episodic elation or irritability, depression, inattention, and psychosocial impairment). However, many of these early presentations are diagnostically nonspecific. The few studies that have followed at-risk youth into adulthood find developmental discontinuities from childhood to adulthood. Biological markers (e.g., amygdalar volume) may ultimately increase our accuracy in identifying children who later develop bipolar I disorder, but few such markers have been identified. Stress, in the form of childhood adversity or highly conflictual families, is not a diagnostically-specific causal agent but does place genetically and biologically vulnerable individuals at risk for a more pernicious course of illness. A preventative family-focused treatment for children with (a) at least one first-degree relative with bipolar disorder, and (b) subsyndromal signs of bipolar disorder, is described. This model attempts to address the multiple interactions of psychosocial and biological risk factors in the onset and course of bipolar disorder.

show abstract

“…Akiskal claims that affective temperaments form the basis of MDs and defines five main affective temperaments (6) in a model aimed at identifying individuals at risk of MDs (7)(8)(9)(10)(11). It has recently been determined that depressive temperament is associated with frequent, recurrent, and severe depression that begins early; hyperthymic temperament is associated with bipolar disorder; and cyclothymic temperament is associated with early onset depression (12,13).…”

Section: Introductionmentioning

confidence: 99%