Cyclosporine <scp>A</scp> up‐regulates <scp>S</scp>onic hedgehog in gingiva: role of the up‐regulation on gingival cell proliferation

Chung, Yuan‐Chiang; Fu, Earl

doi:10.1111/jre.12168

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Furthermore, the low dose of steroids universally used in KT is expected to reduce skin thickness rather than increase it. Interestingly, cyclosporine has been shown to increase sonic hedgehog (SHH) signaling that, in part, drives gingival hyperplasia (14,15). Hedgehog signaling is also a key player in mediating the inflammatory response in BCC (2).…”

Section: Discussionmentioning

confidence: 99%

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas

et al. 2020

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Background/Aim: Squamous cell carcinoma (SCC) is highly prevalent in kidney transplant patients (KT).It is characterized by the presence of an inflammatory infiltrate. In this study, we examined the presence of similar infiltrates in intact skin, which could be regarded as a precancerous step. Patients and Methods: We retrospectively analyzed skin biopsies of 19 non-transplanted patients with a diagnosis of SCC or basal cell carcinoma (BCC) and 17 KT with either SCC or BCC. Results: KT showed increased inflammatory infiltrate in the subepithelial region, compared to non-transplanted patients. The density of basal cell nuclei was also different among the four groups with an interaction effect between tumor type and transplantation. The extent of inflammatory infiltrates did not correlate with the eGFR and proteinuria. Conclusion: KT with a non-melanoma skin cancer show increased intact skin inflammatory infiltrate and alterations in the density of the basal cell layer compared to non-transplanted patients.

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Section: Discussionmentioning

confidence: 99%

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas

et al. 2020

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“…Among the off-target effects of CNI are the reduction of pruritus and erythema 38 excessive hair growth, acne, and, rarely, gum hyperplasia have been reported. 39 The latter might be due to the ability of CNI to increase sonic hedgehog (SHH) which is linked to gingival hyperplasia 40,41 and to the inflammatory response in BCC. 33 A 2010 study has shown that keratinocytes infected by H-rasV12-transducing retrovirus more readily progress to malignancy when CNI are used.…”

Section: The Relationship Between Immunosuppression and The Developmementioning

confidence: 99%

A new hypothesis to explain skin cancer risk in kidney allograft recipients

Viggiano

Lee

Simeoni

et al. 2020

Journal of Onco-Nephrology

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Kidney transplant (KT) recipients have an increased risk for specific types of cancer. Some forms of incident cancer are similarly present in other diseases where T-cells are depleted, such as HIV-infection: specifically, non-Hodgkin lymphoma and Kaposi’s sarcoma. Conversely, other forms of highly incident cancers in KT patients, primarily non-melanoma skin cancer (squamous cell carcinoma and basal cell carcinoma), are specific to this condition. By comparing HIV-related cancers, general cancer incidence, and the association of immunotherapy with cancer incidence, we suggest that the high incidence of non-melanoma skin cancer seen in KT patients is mediated by off-target effects of calcineurin inhibitors in the skin, combined with a “permissive” cancer microinflammatory environment.

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Cyclosporine A up‐regulates Sonic hedgehog in gingiva: role of the up‐regulation on gingival cell proliferation

Cited by 2 publications

References 37 publications

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas

A new hypothesis to explain skin cancer risk in kidney allograft recipients

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