Cyclosporine in Severe Interstitial Cystitis

Forsell, Tapio; Ruutu, Mirja; Isoniemi, Helena; Ahonen, J; Alfthan, O

doi:10.1016/s0022-5347(01)66137-8

Cited by 66 publications

(24 citation statements)

References 14 publications

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“…9 In 1996, Forsell and colleagues reported that cyclosporine (CyA) in 11 patients resulted in a decrease or total disappearance of pain in 10 patients, allowing for a larger volume of urine storage. 10 In 2004, Sairanen and colleagues reported that CyA treatment was safe and effective, and its therapeutic effect was maintained in the long term.…”

Section: Discussionmentioning

confidence: 99%

The combination therapy of prednisolone and tacrolimus for severe painful bladder syndrome/interstitial cystitis

Kaneko

Nishimoto

Ito

et al. 2012

cuaj

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A 47-year-old woman visited our hospital with complaints of frequent urination and intensive pelvic pain. Painful bladder syndrome/interstitial cystitis (PBS/IC) was suspected based on her symptoms. Hydrodistention was performed, and crack and petechial hemorrhage were found, and she was treated with tricyclic antidepressants and antihistamine. However, these treatments were ineffective. An allergy or autoimmune reaction was suspected as the pathogenesis due to eosinophilia and elevation of serum IgE levels. The patient was then treated with immunosuppressive agents. Although her symptoms were not sufficiently improved by single-agent therapy with prednisolone or tacrolimus, they were completely improved by their combined administration. This is the first case to report the effectiveness of combination therapy consisting of prednisolone and tacrolimus to treat PBS/IC.

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Section: Discussionmentioning

confidence: 99%

The combination therapy of prednisolone and tacrolimus for severe painful bladder syndrome/interstitial cystitis

Kaneko

Nishimoto

Ito

et al. 2012

cuaj

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“…[95][96][97][98] Patients with Hunner's lesions seem to derive a better response than those without Hunner's lesions (68% vs. 30%, respectively). 96 A single RCT comparing CyA to PPS showed a significant improvement in IC/BPS symptoms with CyA treatment compared to PPS (59% vs. 13%, p<0.001).…”

Section: Cyclosporine a (Cya) (Option As A Last Resort In Patients Wimentioning

confidence: 96%

CUA guideline: Diagnosis and treatment of interstitial cystitis/ bladder pain syndrome

Cox

Golda

Nadeau

et al. 2016

CUAJ

111

121

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MethodologyThe following guidelines were based on MEDLINE and PUBMED searches of English language literature, in addition to consensus conference proceedings. Levels of evidence and grades of recommendation were assigned for each investigation and treatment, as per the modified Oxford Centre for Evidence-Based Medicine grading system. Where the literature was inconsistent or scarce, a consensus expert opinion was generated to provide treatment guidelines.

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“…Thirty patients with Hunner's ulcer subtype IC showed considerable improvement following endoscopic submucosal injection of triamcinolone [Cox et al 2009]. Other drugs such as cyclosporine have also been shown to relieve the symptoms of severe IC [Sairanen et al 2005;Forsell et al 1996]. In an open-label study in 11 patients with intractable IC, cyclosporine treatment for up to 6 months reduced micturition, urinary frequency, and bladder pain significantly in most of the patients [Forsell et al 1996].…”

Section: Immunosuppressive Agentsmentioning

confidence: 99%

Role of inflammation in bladder function and interstitial cystitis

Grover

Srivastava

Lee

et al. 2011

Therapeutic Advances in Urology

166

140

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Cystitis, or inflammation of the bladder, has a direct effect on bladder function. Interstitial cystitis is a syndrome characterized by urinary bladder pain and irritative symptoms of more than 6 months duration. It commonly occurs in young to middle-aged women with no known cause and in fact represents a diagnosis of exclusion. Many factors have been suggested, including chronic or subclinical infection, autoimmunity and genetic susceptibility, which could be responsible for initiating the inflammatory response. However, a central role of inflammation has been confirmed in the pathogenesis of interstitial cystitis. Patients with interstitial cystitis are usually managed with multimodal therapy to break the vicious cycle of chronic inflammation at every step. Patients who develop irreversible pathologies such as fibrosis are managed surgically, which is usually reserved for refractory cases.

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Cyclosporine in Severe Interstitial Cystitis

Abstract: The findings revive the concept of interstitial cystitis as an autoimmune disease.

Cited by 66 publications

References 14 publications

The combination therapy of prednisolone and tacrolimus for severe painful bladder syndrome/interstitial cystitis

The combination therapy of prednisolone and tacrolimus for severe painful bladder syndrome/interstitial cystitis

CUA guideline: Diagnosis and treatment of interstitial cystitis/ bladder pain syndrome

Role of inflammation in bladder function and interstitial cystitis

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