Cyclosporine in chronic idiopathic urticaria: A double-blind, randomized, placebo-controlled trial

Veña, Gino Antonio; Cassano, Nicoletta; Colombo, Delia; Peruzzi, Elena; Pigatto, Paolo D.

doi:10.1016/j.jaad.2006.04.078

Cited by 195 publications

(133 citation statements)

References 11 publications

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“…Low-dose cyclosporine A in the treatment of severe CSU achieved remission 26-68% (7,8). Vena GA et al reported, after 16 weeks, symptoms scores significantly improved with cyclosporine A treatment group more than placebo, but no patients achieved full remission, and 6% of patients led to discontinuation of treatment due to adverse events (9). The adverse side effects of cyclosporine A require constant monitoring, including its effects on blood pressure and renal function.…”

Section: Methodsmentioning

confidence: 99%

Hydroxychloroquine in the treatment of anti-histamine refractory chronic spontaneous urticaria, randomized single-blinded placebo-controlled trial and an open label comparison study

Boonpiyathad

Sangasapaviliya

2017

Eur Ann Allergy Clin Immunol

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Section: Methodsmentioning

confidence: 99%

Hydroxychloroquine in the treatment of anti-histamine refractory chronic spontaneous urticaria, randomized single-blinded placebo-controlled trial and an open label comparison study

Boonpiyathad

Sangasapaviliya

2017

Eur Ann Allergy Clin Immunol

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“…Its mechanism of action depends on the inhibition of anti-IgE-induced histamine release from basophils and skin mast cells. Cyclosporine at 3-5 mg/kg/day is administered with monitorization of diastolic blood pressure and levels of serum creatinine, serum potassium, serum bilirubin and liver enzymes at each visit [34,35]. Common adverse effects of cyclosporine therapy include hypertension, fatigue, gastrointestinal problems and headache [33].…”

Section: Immunosuppressivesmentioning

confidence: 99%

Urticaria and Angioedema

Engın¹,

Oba²,

Serdaroğlu³

2017

A Comprehensive Review of Urticaria and Angioedema

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Urticaria is a common mast cell-mediated dermatosis presenting with pruritic erythematous superficial plaques also known as hives or wheals. Angioedema is an acute condition manifesting as localized edema affecting the skin and mucous membranes. In contrast with urticaria, itching is often absent, the skin appears normal and the edema occurs in deeper dermal and subcutaneous tissues in angioedema. Spontaneous urticaria can either be acute lasting less than 6 weeks or chronic with a duration of more than 6 weeks. In acute urticaria cases, an underlying cause, mostly medications, foods and infections, may be found in approximately 50% of patients. However, spontaneous urticaria is generally idiopathic. First-line treatment option for both acute and chronic urticaria is non-sedating H 1 antihistamines. Patients with recalcitrant disease are candidates for therapy with corticosteroids, immunosuppressives or omalizumab treatment. There are two different mechanisms causing angioedema. The first is mast cell mediated and is considered to be part of the spectrum of spontaneous or inducible urticarias. Patients present with angioedema alone or angioedema combined with urticaria. The second is bradykinin-induced angioedema, as observed in the hereditary angioedema and angiotensin-converting enzyme (ACE) inhibitor-induced angioedema.

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“…Response of autoreactive CSU to CsA has been associated with disappearance of autoantibodies and CsA may be disease-modifying in these patients [5]. A low-dose CsA treatment (3 mg/kg per day or less) has been shown to cause full remission of symptoms in a number of diferent randomized controlled trials and real-world studies [11][12][13][14].…”

Section: Cyclosporin Amentioning

confidence: 99%

“…Cyclosporin has been reported to be efective in some studies of CSU, including three double-blind [12][13][14][15][16][17][18], and one study reported that 40% of patients achieved complete remission in 9 months [18].…”

Section: Cyclosporin Amentioning

confidence: 99%