Cyclosporine Blood Concentrations Determined by Specific Versus Nonspecific Assay Methods

Blyden, Gershwin T.; Franklin, Cass; Cho, Sang I.; Kaplan, Marshall M.; Hirsch, Carl A.; Greenblatt, David J.

doi:10.1002/j.1552-4604.1986.tb03539.x

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1986

1998

Publication Types

Select...

Article4

Book1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 10 publications

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Rational Therapeutic Drug Monitoring

Friedman¹

1986

JAMA

View full text Add to dashboard Cite

The simple act of ordering a serum drug level does not guarantee that the information will be meaningful or useful. The interpretation of serum concentrations can be profoundly influenced by such factors as the timing of the sample, the patient's clinical state, the drug's pharmacokinetics and metabolism, and the tube type and analytic methodology used. The likelihood of obtaining clinically meaningful and useful results can be maximized when these factors are taken into account.

show abstract

Rational Therapeutic Drug Monitoring

Friedman¹

1986

JAMA

View full text Add to dashboard Cite

show abstract

Assay methods for cyclosporine monitoring following liver transplantation

Haven

Sobeski

Earl

et al. 1990

Clinical Laboratory Analysis

View full text Add to dashboard Cite

This article reviews therapeutic drug monitoring for cyclosporine in liver transplantation. Brief descriptions of various immunoassay methods include sample matrix selection, assay reagents, and metabolite cross-reactivity information. Multiple comparisons of the various methods are outlined. Examples of the method-dependent relationship between clinical events and changes in cyclosporine concentration are presented. Other potential predictors of liver allograft function are listed.

show abstract