Cyclosporine A used as a single drug in the treatment of pure red cell aplasia associated with thymoma

Abstract

REFERENCES v. PEREZ I . Dessypris E N The biology of pure red cell aplasia. Semin Hematol28:275, 1991. 2. Raghavachar A: Pure red cell aplasia: Review of treatment and proposal for a 3. Masaoka A. Hashimoto T, Shibata K , Yamakawa Y, Nakamae K, lizuka M: 4. Marmont AM: Therapy of pure red cell aplasia. Semin Hematol 28:28S, 1991. 5. Leonard EM, Raefsky E. Griffith P, Kimball J. Nienhuis AW, Young NS: Cyclosporine therapy of aplastic anaemia, congenital and acquired red cell aplasia. Br J Haematol 72:278, 1989. treatment strategy. Blur 61:47, 1990.Thymomas associated with pure red cell aplasia.

Long-term response and outcome following immunosuppressive therapy in thymoma-associated pure red cell aplasia: a nationwide cohort study in Japan by the PRCA collaborative study group

“…5,6 Thymomaassociated PRCA is generally thought to be an organspecific autoimmune disease as well as an idiopathic form, and immunosuppressive therapy, including corticosteroids, cyclophosphamide and cyclosporine, has been reported to be useful. 5,7,8,9 Thompson et al recently reported their 50-year single institution experience with 13 patients with thymoma-associated PRCA, 10 and showed that surgical resection of the thymoma was insufficient to induce normalization of erythropoiesis, and that anti-thymocyte globulin was an effective adjuvant treatment but associated with high treatmentrelated morbidity due to frequent infectious complications. However, the optimal management of thymomaassociated PRCA and the long-term outcome after immunosuppressive therapy remain unclear because of the rarity of this disorder.…”

Thymoma with Concomitant Pure Red Cell Aplasia, Good’s Syndrome and Myasthenia Gravis Responding to Rituximab

“…Although the optimal management of this disorder remains unknown, a variety of immunosuppressive therapies, namely cyclosporine A and cyclophosphamide have shown efficacy in this setting [13,14].…”

Pure red-cell aplasia occurring 12 years after thymectomy: Successful treatment with cyclosporine

“…Oral cyclosporine (CSA) therapy (4 mg/kg/day) was started in August 1995 [2,3]. Serum concentration of CSA was maintained at a range of 200-2.50 ng/ml.…”