Cyclosporine A in psoriasis

Rebora, Alfredo

doi:10.1016/0738-081x(91)90081-u

Cited by 4 publications

(3 citation statements)

References 53 publications

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“…The success of cyclosporine A for treating psoriasis [48, 49] highlights the crucial role played by T cells in the pathophysiology of psoriasis [50]. The rapid immunosuppressive action of cyclosporine is related to the suppression of T lymphocytes and the subsequent drop in IL-2 levels [48].…”

Section: Resultsmentioning

confidence: 99%

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Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

2018

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Background: Psoriasis is a common, chronic inflammatory skin disorder, which can significantly impact quality of life. Despite major breakthroughs in our understanding of the pathogenesis of psoriasis, the chronological order of the underlying mechanisms leading to the development of psoriatic plaques remains to be completely understood. Summary: Although psoriasis is classically perceived as a T-cell disease, it is now well recognized that T lymphocytes do not function in exclusivity. This theory is supported by evidence from transgenic murine models that develop marked psoriasiform disease. In addition, immune cells and cytokines regulate both early and late events involved in the pathogenesis of psoriasis. Key Messages: Psoriasis is a complex disease – a dynamic interplay between immune cells, keratinocytes, and various other skin-resident cells, such as endothelial and immune cells. The contribution of each cell type is crucial in the initiation and maintenance phases of psoriatic alterations.

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Section: Resultsmentioning

confidence: 99%

“…The rapid immunosuppressive action of cyclosporine is related to the suppression of T lymphocytes and the subsequent drop in IL-2 levels [48]. These observations led to the notion that psoriasis was a T-cell-mediated disease [51].…”

Section: Resultsmentioning

confidence: 99%

Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?

2018

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“…In addition, keratinocytes express HLA-C*0602, which has antigens typical of TCD8+ cells and not CD4+ cells [ 49 ]. The efficacy of treatment with cyclosporin A [ 116 , 117 ] correlated with T lymphocyte inhibition and IL-2 reduction [ 116 ] has highlighted the significant role played by these cells in the pathogenesis of the disease. CD4+ Th17 can release IL-17, IL-23 [ 118 ], IL-22 [ 119 ], IFN-γ, and TNF-α.…”

Section: Cell Types Involved In the Pathogenesis Of Psoriasismentioning

confidence: 99%

Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?

et al. 2022

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Psoriasis is one of the most widespread chronic inflammatory skin diseases, affecting about 2%–3% of the worldwide adult population. The pathogenesis of this disease is quite complex, but an interaction between genetic and environmental factors has been recognized with an essential modulation of inflammatory and immune responses in affected patients. Psoriatic plaques generally represent the clinical psoriatic feature resulting from an abnormal proliferation and differentiation of keratinocytes, which cause dermal hyperplasia, skin infiltration of immune cells, and increased capillarity. Some scientific pieces of evidence have reported that psychological stress may play a key role in psoriasis, and the disease itself may cause stress conditions in patients, thus reproducing a vicious cycle. The present review aims at examining immune cell involvement in psoriasis and the relationship of depression and stress in its pathogenesis and development. In addition, this review contains a focus on the possible use of natural products, thus pointing out their mechanism of action in order to counteract clinical and psychological symptoms.

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