Cyclosporine a and Pentosan Polysulfate Sodium for the Treatment of Interstitial Cystitis: A Randomized Comparative Study

Sairanen, Jukka; Tammela, Teuvo L.J.; Leppilahti, Mikael; Multanen, Markku; Paananen, Ilkka; Lehtoranta, Kari; Ruutu, Mirja

doi:10.1097/01.ju.0000181808.45786.84

Cited by 129 publications

(74 citation statements)

References 15 publications

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“…Thirty patients with Hunner's ulcer subtype IC showed considerable improvement following endoscopic submucosal injection of triamcinolone [Cox et al 2009]. Other drugs such as cyclosporine have also been shown to relieve the symptoms of severe IC [Sairanen et al 2005;Forsell et al 1996]. In an open-label study in 11 patients with intractable IC, cyclosporine treatment for up to 6 months reduced micturition, urinary frequency, and bladder pain significantly in most of the patients [Forsell et al 1996].…”

Section: Immunosuppressive Agentsmentioning

confidence: 99%

“…Recently, in a randomized study on 64 patients with IC that met NIDDK criteria, patients were treated with either cyclosporine or pentosan polysulfate for 6 months. The clinical response rate was determined using the Global Response Assessment and was found to be 75% for cyclosporine, compared with 19% for pentosan polysulfate (p < 0.001) [Sairanen et al 2005].…”

Section: Immunosuppressive Agentsmentioning

confidence: 99%

See 1 more Smart Citation

Role of inflammation in bladder function and interstitial cystitis

Grover

Srivastava

Lee

et al. 2011

Therapeutic Advances in Urology

164

140

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Cystitis, or inflammation of the bladder, has a direct effect on bladder function. Interstitial cystitis is a syndrome characterized by urinary bladder pain and irritative symptoms of more than 6 months duration. It commonly occurs in young to middle-aged women with no known cause and in fact represents a diagnosis of exclusion. Many factors have been suggested, including chronic or subclinical infection, autoimmunity and genetic susceptibility, which could be responsible for initiating the inflammatory response. However, a central role of inflammation has been confirmed in the pathogenesis of interstitial cystitis. Patients with interstitial cystitis are usually managed with multimodal therapy to break the vicious cycle of chronic inflammation at every step. Patients who develop irreversible pathologies such as fibrosis are managed surgically, which is usually reserved for refractory cases.

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Section: Immunosuppressive Agentsmentioning

confidence: 99%

Section: Immunosuppressive Agentsmentioning

confidence: 99%

Role of inflammation in bladder function and interstitial cystitis

Grover

Srivastava

Lee

et al. 2011

Therapeutic Advances in Urology

164

140

View full text Add to dashboard Cite

show abstract

“…96 A single RCT comparing CyA to PPS showed a significant improvement in IC/BPS symptoms with CyA treatment compared to PPS (59% vs. 13%, p<0.001). 99 This trial was not placebo-controlled and side effects occurred in 94% of CyA patients and 56% of PPS patients.…”

Section: Cyclosporine a (Cya) (Option As A Last Resort In Patients Wimentioning

confidence: 99%

CUA guideline: Diagnosis and treatment of interstitial cystitis/ bladder pain syndrome

Cox

Golda

Nadeau

et al. 2016

CUAJ

109

121

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MethodologyThe following guidelines were based on MEDLINE and PUBMED searches of English language literature, in addition to consensus conference proceedings. Levels of evidence and grades of recommendation were assigned for each investigation and treatment, as per the modified Oxford Centre for Evidence-Based Medicine grading system. Where the literature was inconsistent or scarce, a consensus expert opinion was generated to provide treatment guidelines.

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“…57 A group of 64 patients were randomized to receive either a low dose of CA (3 mg/kg) or PPS 100 mg three times a day. CA was superior to PPS in all clinical outcomes.…”

Section: Resultsmentioning

confidence: 99%