Cyclosporine

Sekhon, Sahil; Bhutani, Tina; Koo, John

doi:10.1016/b978-0-323-61211-1.00017-6

Cited by 5 publications

(2 citation statements)

References 101 publications

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“…Calcineurin inhibition leads to reduced transcription of IL-2, which results in a decline in the number of activated CD4+ and CD8+ T-cells in the epidermis. 32 It is indicated for the prevention of organ rejection in kidney, liver, and heart allogeneic transplants. It is also indicated for the treatment of patients with rheumatoid arthritis that have not adequately responded to MTX and for patients with plaque psoriasis who have failed to respond to at least one systemic therapy.…”

Section: Systemic Therapymentioning

confidence: 99%

“…33 CsA is an effective off-label treatment for childhood and adult AD, and it is approved to treat adult AD in Europe. 32 A double-blind, placebo-controlled, crossover RCT of 33 adults with severe refractory AD showed significant improvements in disease activity and extent of disease scores with 8 weeks of treatment compared to placebo. Once CsA was stopped, relapse was rapid, but the mean scores for disease activity and extent of disease were less than their baseline values.…”

Section: Systemic Therapymentioning

confidence: 99%

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Current Perspectives on the Systemic Management of Atopic Dermatitis

Davari¹,

Nieman²,

McShane³

et al. 2021

JAA

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Atopic dermatitis (AD) is a common disease of childhood, and some patients experience a prolonged clinical course into adolescence and adulthood. Systemic management is required when AD is not adequately controlled with topical medications. Our aim is to provide a comprehensive review of commonly used systemic immunomodulating agents in childhood and adult AD, including cyclosporine A (CsA), azathioprine (AZA), methotrexate (MTX) and mycophenolate mofetil (MMF), which are prescribed off-label in the United States, as well as dupilumab, an FDA-approved biologic. We will also provide a brief overview of emerging systemic therapies currently under investigation.

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Section: Systemic Therapymentioning

confidence: 99%

Section: Systemic Therapymentioning

confidence: 99%