Cyclosporin in less common immune-mediated skin diseases

Ruzicka, Thomas

doi:10.1111/j.1365-2133.1996.tb00709.x

Cited by 14 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CSA and its derivatives have been widely used as immunosuppressive agents after organ transplant since the 1980s with much success. CSA is now widely used for patients with psoriasis and atopic eczema for cutaneous application 6 . As a biologic agent, CSA binds to cyclophylin, a cytoplasmic protein, which together bind to calcineurin B with high affinity 7 .…”

Section: Introductionmentioning

confidence: 99%

“…CSA is now widely used for patients with psoriasis and atopic eczema for cutaneous application. 6 As a biologic agent, CSA binds to cyclophylin, a cytoplasmic protein, which together bind to calcineurin B with high affinity. 7 The calcineurin complex consists of three subunits, the catalytic A subunit, the regulatory B subunit, and calmodulin.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Basis of Posttransplant Squamous Cell Carcinoma: The Potential Role of Cyclosporine A in Carcinogenesis

et al. 2006

View full text Add to dashboard Cite

Cyclosporine (CSA) is a widely used immunosuppressive agent, predominantly for transplant patients. It is well recognized that transplant patients are prone to develop squamous carcinoma of the skin and mucosa, and this high incidence of squamous carcinoma in the transplant population cannot be explained by immunosuppression alone. We hypothesize that CSA may play a significant role in the transformation of normal epidermal squamous cells to carcinoma. CSA is a specific ligand for calcineurin, a ubiquitously expressed cellular serine/threonine phosphatase, that plays important roles in the immune system and cardiac muscles. Using global gene-profiling methods, we studied the short-time CSA effect on the squamous cell line (SCC-015) using Affymetrix human gene chips (Human U133, 2.0 plus chip). Multiple groups of genes were identified to be responsive to CSA treatment, including many genes of unknown functions. We then used reverse transcriptase-polymerase chain reaction and immunoblot analyses to selectively confirm the results from the chips analyses with emphasis on the regulatory molecules important for cellular functions of apoptosis, DNA damage repair, and cellular transformation. This global gene-profiling study indicated that CSA not only functions as an immunosuppressant on the immune system, but also activates/inhibits a wide array of genes important for cell-cycle regulation, apoptosis, and oncogene/tumor-suppressor activation. These functions of CSA on skin and mucosa systems at the molecular level are likely important in the pathogenesis of squamous carcinoma in transplant patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular Basis of Posttransplant Squamous Cell Carcinoma: The Potential Role of Cyclosporine A in Carcinogenesis

et al. 2006

View full text Add to dashboard Cite

show abstract

“…27,28 It may well have had a bene®cial effect, in addition to the prednisolone, when it was initially given to our patient, but the development of a severe headache, a well-recognized side-effect, limited the use of this treatment. Cyclosporin has been reported to be effective in severe recalcitrant cases of pyoderma gangrenosum, 21,29,30 with apparently no reported treatment failures. 31 A marked acceleration in healing of our patient's vast perineal wound was seen after cyclosporin was started.…”

Section: Discussionmentioning

confidence: 99%

Pyoderma gangrenosum associated with Takayasu's arteritis responding to cyclosporin

La¹,

Ross²,

Farrell³

et al. 1999

British Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…73 T-cell-mediated skin diseases, such as lichen planus, represent a potential area of use. Animal studies in mice with lupus hold promise that the drug might be beneficial in cutaneous autoimmune diseases.…”

Section: Future Perspectivesmentioning

confidence: 99%