Abstract:Wenzel and colleagues recently concluded that an endothelin-A (ET-A) receptor antagonist attenuates the skin vasoconstriction produced by angiotensin II (Ang II) and noradrenaline (NA) [1]. The postulate that the selective ET-A antagonist, BQ123, blocks Ang II and NA mediated vasoconstriction challenges well-established physiological and pharmacological concepts, in particular, the notion of specific receptors for these peptidergic and nonpeptidergic substances. We believe that the double injection technique (… Show more
Resolution of the oedema with stoppage of amlodipine confirms its culprit as a cause of the oedema. To our knowledge, this is the largest case series of amlodipine-related generalised oedema in the paediatric population.
Resolution of the oedema with stoppage of amlodipine confirms its culprit as a cause of the oedema. To our knowledge, this is the largest case series of amlodipine-related generalised oedema in the paediatric population.
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