Cyclosporin-A-induced hair growth in human renal allograft recipients and alopecia areata

Gebhart, W.; Schmidt, J B; Schemper, M.; Spona, J.; Kopsa, H; Zazgórnik, J

doi:10.1007/bf00412931

Cited by 44 publications

(12 citation statements)

References 6 publications

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“…PUVA may be successful (WEISSMANN et al 1978), but proof is lacking and maintenance therapy is difficult. Immunomodulators, cyclosporin A (GEBHART et al 1986) and methisoprinol (GALBRATH et al 1984) look promising in view of the likely immune basis for alopecia areata, but only solitary case reports have been published. Early reports of succesful treatment with topical minoxidil (WEISS et al 1981;FENTON and WILKINSON 1983;WEISS et al 1984) have not been repeated.…”

Section: J Treatments For Alopecia Areata and Alopecia Totalismentioning

confidence: 97%

The Effect of Drugs on Hair

Simpson¹

1989

Pharmacology of the Skin II

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Section: J Treatments For Alopecia Areata and Alopecia Totalismentioning

confidence: 97%

The Effect of Drugs on Hair

Simpson¹

1989

Pharmacology of the Skin II

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“…Clinical symptoms were clearly improved by a daily dose of 1-5 mg CS/kg BW. An im provement of ichthyosis was also found [7], An improvement of hair growth in patients with alopecia areata or male-pattern alope cia has been reported [8,9], While Kato et al [10,11] were unable to demonstrate any direct epidermal action of CS using therapeutic doses, in vitro studies by Furue et al [12] showed an antiprolifera tive effect in cultured normal and trans formed keratinocytes. Corresponding results based on in vivo studies do not yet exist.…”

Section: Introductionmentioning

confidence: 99%

Influence of Ciclosporin on Epidermal Proliferation after Mechanical Skin Irritation

Kietzmann

Lubach²,

Wonigeit³

1990

Pharmacology

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In mice (NMRI and hr/hr), ciclosporin, subcutaneously administered once daily over 7–10 days, influenced epidermal hyperproliferation induced by abrasion of superficial epidermal layers. While in vehicle-treated control animals the mechanical irritation of skin caused an increase in ³H-thymidine triphosphate incorporation rate into DNA and also in epidermal thickness of tail and flank skin, the hyperproliferative response was diminished in ciclosporin-treated animals. Thus, only a slight increase of the ³H-thymidine triphosphate incorporation rate and of epidermal thickness was measured after pretreatment with ciclosporin, the effect being dose-dependent. The strongest inhibitory activity was found after application of 30 mg/kg BW. These findings indicate that the immunosuppressive peptide ciclosporin inhibits the epidermal proliferation in vivo.

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“…In 1986, Gebhart et al [4] investigated ovarian, adrenal and gonadotropin-releasing hormones in CSA-treated renal allograft re cipients. One patient had suffered from AA for more than 30 years.…”

Section: Csa and Aamentioning

confidence: 99%

Effects of Cyclosporin A on Hair

Lutz¹

1994

Skin Pharmacol Physiol

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Cyclosporin A (CSA) is an immunosuppressive agent that has provided new approaches in transplantation medicine and in the treatment of autoimmune diseases. One of the most common dermatological side effects of oral CSA is dose-dependent hypertrichosis. This stimulating effect on hair growth encouraged a number of investigators to use CSA not only in the treatment of alopecia areata (AA), but also in male pattern alopecia (MPA). While oral application proved successful, the beneficial effect of topical application was very limited in both AA and MPA.

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Cyclosporin-A-induced hair growth in human renal allograft recipients and alopecia areata

Cited by 44 publications

References 6 publications

The Effect of Drugs on Hair

The Effect of Drugs on Hair

Influence of Ciclosporin on Epidermal Proliferation after Mechanical Skin Irritation

Effects of Cyclosporin A on Hair

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