Cyclopia-otocephaly-agnathia-synotia-astomia complex: A case report

Singh, Kanwar; Sharma, Shruti; Agarwal, Khushboo; Kalra, Abhimanyu

doi:10.4103/jcn.jcn_23_18

Cited by 2 publications

(4 citation statements)

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“…However, various risk factors implicated include genetic factors and chromosomal anomalies (mostly trisomy D), multiple pregnancies (especially twin pregnancy), previous unexplained miscarriages, maternal diabetes, infections during pregnancy (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus), exposure to UV light and ionic radiation, smoking, alcohol and certain drugs during pregnancy (such as salicylates, amidopyrine, corticosteroids, aspirin, lithium, anticonvulsants, retinoic acid, anticancer agents, cyclopamine [Veratrum californium, found in corn lily or false hellebore]). 1,3,5,[13][14][15][16][17] However, in the presented case, no risk factors could be identified.…”

Section: Discussionmentioning

confidence: 99%

A rare case report of a cyclopian malformation

Priya

Mukherjee

Singh

2023

Int J Reprod Contracept Obstet Gynecol

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A rare form of median faciocerebral dysplasia, characterized by a single central orbital fossa with a tubular nose-like appendage above the orbit is known as cyclopian malformation/monster. It is the most severe form of alobar holoprosencephaly. Since most of these cases are sporadic, incompatible with life, and due to the limited literature knowledge, the exact etiology of this condition remains undetermined. However, various risk factors implicated include genetic factors and chromosomal anomalies (mostly trisomy D). Here we present a case of stillborn male cyclopian fetus born to a 34 year old 3rd gravida by caesarean section. There was no history of any drugs or alternative medicine intake (except iron-folic acid, calcium, thyroxin), radiation exposure, or a significant family history or consanguinity. Her only 33-week scan (done at a peripheral center) failed to identify any fetal abnormality. This case is reported because cyclopia is a rare/uncommon developmental anomaly especially with the advancement in antenatal ultrasonography to identify malformed fetuses early in pregnancy.

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Section: Discussionmentioning

confidence: 99%

A rare case report of a cyclopian malformation

Priya

Mukherjee

Singh

2023

Int J Reprod Contracept Obstet Gynecol

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“…The exact causes of cyclopia remain unknown [4] . However, researchers believe that several factors can increase the risk of cyclopia.…”

Section: Discussionmentioning

confidence: 99%

“…Another risk factor related to this anomaly is Veratrum californicum , found in corn lily or false hellebore. It is implicated in causing cyclopia (when ingested believing the plant to be hellebore, which can cure the morning sickness symptoms associated with the first few months of pregnancy) [4] , [5] .…”

Section: Discussionmentioning

confidence: 99%

“…In this health condition, the eye's orbits are not properly divided into two cavities so that they can be seen either as a single eye field or two bilateral fields that are very close to each other [3] . This congenital disorder affects both animals and humans [4] . Patients with cyclopia syndrome typically have a missing or dysfunctional nose with a long snout.…”

Section: Introductionmentioning

confidence: 99%

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