Cyclophosphamide versus cytarabine mobilization of hematopoietic stem cells with G-CSF stimulation in myeloma patients subjected to autologous stem cell transplantation

Abstract

The aim of our study was to compare different regimes of hematopoietic stem cell (HSC) mobilization, i.e., cyclophosphamide combined with granulocyte colony-stimulating factor (Cy/G-CSF), versus cytarabine with G-CSF (Ara-C/G-CSF). Efficiency and toxicity of these treatment regimens were assessed. Achievement of partial remission of the disease was sufficient for successful mobilization. CD34+ cell numbers in the blood showed a significant correlation with total number of CD34+ yielded by apheresis on the same day. When comparing the two groups of mobilization we have revealed that the patients treated with AraC + G-CSF yielded higher amounts of CD34+ cells in peripheral blood on the first apheresis day. Moreover, lesser occurrence of toxicity was revealed in group of patients treated with AraC-G-CSF.