2018
DOI: 10.1016/j.virol.2018.06.011
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Cyclophilins and cyclophilin inhibitors in nidovirus replication

Abstract: Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several of its non-immunosuppressive analogs, which can also block the replication of nidoviruses (arteriviruses and coronaviruses). Cyclophilins have been reported to play an essential role in the replication of several other RNA viruses, including human immunodeficiency virus-1, hepatitis C virus, and influenza A virus. Likewise, the r… Show more

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Cited by 66 publications
(76 citation statements)
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References 139 publications
(176 reference statements)
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“…Finally, as expected, the non-immunosuppressive cyclosporin A analogue alisporivir inhibited SARS-CoV-2 replication, as demonstrated previously for SARS-CoV and MERS-CoV [58]. Although the exact mode of action of this inhibitor is unclear, it is thought to modulate CoV interactions with members of the cyclophilin family [108]. Unfortunately, all of these in vitro antiviral activities should probably be classified as modest, emphasizing the urgency of large-scale drug repurposing and discovery programmes that target SARS-CoV-2 and coronaviruses at large.…”
Section: Discussionsupporting
confidence: 80%
“…Finally, as expected, the non-immunosuppressive cyclosporin A analogue alisporivir inhibited SARS-CoV-2 replication, as demonstrated previously for SARS-CoV and MERS-CoV [58]. Although the exact mode of action of this inhibitor is unclear, it is thought to modulate CoV interactions with members of the cyclophilin family [108]. Unfortunately, all of these in vitro antiviral activities should probably be classified as modest, emphasizing the urgency of large-scale drug repurposing and discovery programmes that target SARS-CoV-2 and coronaviruses at large.…”
Section: Discussionsupporting
confidence: 80%
“…Cyclophilins are a class of highly conserved cellular proteins, which have specific chemical structures containing 109 amino acids and could interact with other proteins from different locations and of multiple functions [14,15]. Previous reports indicated the main functions of cyclophilins was protein folding and trafficking [16].…”
Section: Introductionmentioning
confidence: 99%
“…Finally, as expected, the non-immunosuppressive cyclosporin A analogue Alisporivir inhibited SARS-CoV-2 replication, as demonstrated previously for SARS-CoV and MERS-CoV (58). Although the exact mode of action of this inhibitor it is unclear, it is thought to modulate CoV interactions with members of the cyclophilin family (108). Unfortunately, all of these in vitro antiviral activities should probably be classified as modest, emphasizing the urgency of large-scale drug repurposing and discovery programmes that target SARS-CoV-2 and coronaviruses at large.…”
Section: Discussionmentioning
confidence: 99%