Cyclophilin A produced by thymocytes regulates the migration of murine bone marrow cells

Хромых, Л. М.; Куликова, Н. А.; Anfalova, T. V.; Muranova, T.A.; Abramov, Vyacheslav M.; Vasiliev, Anatoliy M.; Khlebnikov, V. S.; Kazansky, Dmitry

doi:10.1016/j.cellimm.2007.11.002

Cited by 39 publications

(35 citation statements)

References 29 publications

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“…Moreover, TgCyp18, which is similar in action to MIP-1␤, which binds CCR5, can attract mouse DCs in vitro (3). Furthermore, it has been reported that the secretory form of CypA possesses chemotactic activity, regulating the migration of DCs, monocytes, neutrophils, eosinophils, B lymphocytes, and T lymphocytes through its interaction with CD147, a type I transmembrane glycoprotein (13,26,41,44). Our study showed that TgCyp18 elicited macrophage and spleen cell migration in a dose-and CCR5-dependent fashion.…”

Section: Discussionsupporting

confidence: 57%

Toxoplasma gondiiCyclophilin 18 Regulates the Proliferation and Migration of Murine Macrophages and Spleen Cells

Ibrahim

Xuan

Nishikawa

2010

Clin Vaccine Immunol

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Section: Discussionsupporting

confidence: 57%

Toxoplasma gondiiCyclophilin 18 Regulates the Proliferation and Migration of Murine Macrophages and Spleen Cells

Ibrahim

Xuan

Nishikawa

2010

Clin Vaccine Immunol

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“…24 The chemotactic activities of extracellular CyPA depend on Bsg, which serves as the primary binding site for CyPA on target cells. 25 Inflammation is augmented by cytokines/chemokines and growth factors secreted from perivascular inflammatory cells.…”

Section: Vascular Bsg Is Essential For Hypoxia-induced Phmentioning

confidence: 99%

Basigin Mediates Pulmonary Hypertension by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation

Satoh

Kikuchi

et al. 2014

Circulation Research

103

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“…The secreted form of Cyp-A is a potent chemoattractant for macrophage colony-stimulating factor (MCSF)-dependant macrophages (Comalada et al, 2003;Sà nchez-Tilló et al, 2006), monocytes (Galat, 1993;Payeli et al, 2008), neutrophils (Sherry et al, 1992), eosinophils (Xu et al, 1992), and T cells (Kasinrerk, 1999). This molecule is involved in the adhesion of monocytes/macrophages to the extracellular matrix (Yang et al, 2008) and the migration of murine bone marrow cells (Khromykh et al, 2007). In addition, the secreted form modulates osteoblastic activity (Andersen et al, 2003) as well as the functions of endothelial cells via paracrine and autocrine modes (Kim et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Differential Expression of Cyclophilin A and EMMPRIN in Developing Molars of Rats

Yang

Park

Kim

et al. 2011

The Anatomical Record

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A complex and intricate cascade of gene expression is essential for late stage tooth development. This study was performed to detect molecules involved in dental hard tissue formation and tooth eruption by comparing gene expression in cap stage molar germs (before eruptive movement and dental hard tissue formation) with that in root formation stage molar germs (after eruptive movement and dental hard tissue formation). DD-PCR revealed that cyclophilin A (Cyp-A), a potent chemoattractant for monocytes as well as a ligand for extracellular matrix metalloproteinase inducer (EMMPRIN) was expressed differentially in the two stages molar germs. The levels of Cyp-A and EMMPRIN mRNA were significantly higher at the root formation stage than at the cap and crown stages of the molar germs. Immunofluorescence showed that Cyp-A and EMMPRIN were expressed strongly in the follicular cells overlaying the occlusal region of the molar germs at the root formation stage. In contrast, their immunoreactivity was weak in the follicular tissues and was not region-specific in molar germs at the cap stage. In addition, the MCP-1 and CSF-1 mRNA levels increased in parallel to that of Cyp-A mRNA and the increased number of osteoclasts at the occlusal region. Immunoreactivity against Cyp-A and EMMPRIN was also observed in the fully differentiated ameloblasts and odontoblasts. This study suggests that Cyp-A and EMMPRIN play roles in the maturation of dental hard tissue and the formation of an eruption pathway. Anat Rec, 295:150-159, 2012. V V C 2011 Wiley Periodicals, Inc.

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Cyclophilin A produced by thymocytes regulates the migration of murine bone marrow cells

Cited by 39 publications

References 29 publications

Toxoplasma gondiiCyclophilin 18 Regulates the Proliferation and Migration of Murine Macrophages and Spleen Cells

Toxoplasma gondiiCyclophilin 18 Regulates the Proliferation and Migration of Murine Macrophages and Spleen Cells

Basigin Mediates Pulmonary Hypertension by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation

Differential Expression of Cyclophilin A and EMMPRIN in Developing Molars of Rats

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