Cyclopentadienyl molybdenum(II) compounds bearing carboxylic acid functional group

Cyclopentadienyl Molybdenum(II) Compounds Bearing Ether and Thioether Functions in the Side Chain: Synthesis, Characterization, and Cytotoxic/Cytostatic Studies

“…(5-NH 2 Phen). [19][20][21][22] Indenyl molybdenum compounds bearing 4,7-Ph 2 Phen and 2,2'-biquinoline (bq) exhibit high in vitro activity against human colorectal cancer cells HT-29 and gastric cancer cells MKN45, GP-202 and GP-220. [18] However, scrutinizing a wider range of compounds bearing modified Cp/Ind ring has shown unusually high cytotoxicity against MOLT-4 and HL-60 leukemia cells for particular complexes of 2,2'-bipyridine (bpy) [23] even though parent cyclopentadienyl species [(η 5 -Cp)Mo(CO) 2 (bpy)][BF 4 ] is almost inactive.…”

“…Strong effect of coordinated chelating ligand on in vitro cytotoxic activity of [(η 5 ‐Cp’)Mo(CO) 2 (L)][BF 4 ] has been well documented already in the early stage of investigation on mouse Ehrlich ascites tumor cells [18] and human MOLT‐4 leukemia cells [19] while effects of cyclopentadienyl (Cp) ligand substitution seemed to be negligible for a long time [19,20] as several substitution patterns brought only minor lowering of half‐maximal inhibitory concentrations (IC 50 ). Studies on MOLT‐4 cell line documented a high cytotoxicity for various species bearing modified Cp/Ind ring and following N,N’ ‐chelating ligands: 1,10‐phenanthroline (phen), 4,7‐diphenyl‐1,10‐phenanthroline (4,7‐Ph 2 Phen), 5‐amino‐1,10‐phenanthroline (5‐NH 2 Phen) [19–22] . Indenyl molybdenum compounds bearing 4,7‐Ph 2 Phen and 2,2’‐biquinoline (bq) exhibit high in vitro activity against human colorectal cancer cells HT‐29 and gastric cancer cells MKN45, GP‐202 and GP‐220 [18] .…”