Cyclopentadienyl iron dicarbonyl (CpFe(CO)₂) derivatives as apoptosis-inducing agents

Abstract

CpFe(CO)2 complexes kill cancer cells while leaving normal cells unharmed.

Easily Available, Amphiphilic Diiron Cyclopentadienyl Complexes Exhibit in Vitro Anticancer Activity in 2D and 3D Human Cancer Cells through Redox Modulation Triggered by CO Release

“… Structures of cyclopentadienyl iron complexes that show anticancer activity (plus year of publication). I ) L=PPh 2 (alkyl), Y=C(O)Me (2020); [10a] L=CO, Y=Cl, Br, I, NCS, SCN (2016); [10b] L=PPh 3 or related ring‐substituted molecule, Y=I (2017) [10c] . II ) R=Ph, 4‐C 6 H 4 CO 2 H or 4‐C 6 H 4 F, R′=4‐C 6 H 4 NH 2 , X=PF 6 (2017); [10c] R=Ph, R′=aryl or vinyl, X=CF 3 SO 3 (2020) [11c] .…”

Iron‐Promoted Radical Reactions: Current Status and Perspectives

“…[16] The properties of these complexes to generater adical species can be exploited to induce apoptosis in breast cancer cells and HeLa cell lines, whilst normalc ellsr emained unaffected. [17] Interestingly,c omplex CpFe(CO) 2 I( 8c)w as metabolically stable and easily permeateda cross alipid barrier.…”

“…Unsaturated trichloroacetates (16,18)t hat contained different carbon chains were cyclized through an ATRA (atom-transfer radical addition) reactioni nt he presence of FeCl 2 (3-10 mol %) in 1,2-dichloroethane (DCE) at 80 8C. Five-, eight-, nine-, and ten-membered lactones (17,19)w ere obtainedi n moderate yields (up to 55 %f or the five-membered ring; Scheme6). [21] This reactionp roceeds through either at ypeA mechanism or ar adical-chain mechanism.T he radical that is formed by the addition of RCOCl 2 C to the alkene is able to recycle the Fe II center by abstracting aC l C radical.…”

A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity against Colorectal and Triple Negative Breast Cancer Cells

“…Our preliminary results on the [Fe(η 5 -Cp)(dppe)(L)] + compounds, where L is an imidazole [18], a quinolinecarbonitrile [19], or a pyrazinecarbonitrile [19]-based ligand (Figure 1b), have validated the strategy. Later works by us [20], Fan et al, [21], and Dyson, Marchetti et al, [22] on {Fe(Cp)(CO)n} or {Fe2(Cp)2(CO)2} based-compounds showed that the replacement of dppe by monodentate ligands allows for the synthesis of stable and more water soluble complexes (Figure 1ce). In particular, we have explored different substituents on the phosphane ligands of [Fe(η 5 -Cp)(CO)(phosphane)(aminobenzonitrile)] + compounds, concluding that triphenylphosphane was the ligand that imparted a better cytotoxic profile to the compounds on human cervical cancer cells (HeLa).…”