Cyclooxygenase-derived products, rather than nitric oxide, are endothelium-derived relaxing factor(s) in the ventral aorta of carp (Cyprinus carpio)

Park, Kwan Ha; Kim, Kyong-Ho; Choi, Min-Soon; Choi, Sang‐Hoon; Yoon, Jong‐Man; Kim, Young-Gill

doi:10.1016/s0305-0491(00)00264-9

Cited by 18 publications

(12 citation statements)

References 24 publications

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“…4B). While this result is in agreement with previous studies, which established a role for PGs in A23187-mediated vasodilation in fish vessels Park et al, 2000;Jennings et al, 2004), it raises an interesting point. If INDO specifically blocks PG-related pathways and L-NIO specifically blocks the production of NO, then why did blocking only one of these two pathways still result in the complete elimination of a vasodilator response?…”

Section: Vasoactivity Of Recombinant Il-1β and The Effect Of Temperaturesupporting

confidence: 74%

“…NO and PGs) in rIL-1β-induced vasodilation, we needed to remove (denude) the endothelial cell layer of some coronary arterioles while leaving the vascular smooth muscle intact and functional. There are a number of studies where physical denudation of the vascular endothelium of fish vessels has been performed (Farrell and Johansen, 1995;Miller and Vanhoutte, 2000;Park et al, 2000). However, the vessels used in the latter studies were considerably larger than the ones used in the present research (80-150 µm external diameter), and the use of physical methods proved impossible.…”

Section: Role Of the Endothelium No And Prostaglandins In Ril-1β-indmentioning

confidence: 41%

“…2A,B); and (2) exposing vessels to increasing concentrations of the endotheliumdependent calcium ionophore A23187, which causes a concentrationdependent relaxation of teleost blood vessels Park et al, 2000;Jennings et al, 2004) and measuring changes in the vessel's ID at 10 min post-injection before and after denudation (Fig. 2C).…”

Section: Role Of the Endothelium No And Prostaglandins In Ril-1β-indmentioning

confidence: 99%

“…Several studies have indicated that A23187 is an endothelium-dependent vasodilator of fish vessels Park et al, 2000;Jennings et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, because of the controversy surrounding the involvement of NO and PGs as endothelial-derived relaxation factors (EDRFs) in fish (see Kågström and Holmgren, 1997;Park et al, 2000;Jennings et al, 2004), we decided to investigate the possible role played by these two vasoactive agents in the concentration-dependent vasodilation induced by the endothelium-dependent calcium ionophore A23187. Several studies have indicated that A23187 is an endothelium-dependent vasodilator of fish vessels Park et al, 2000;Jennings et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Recombinant interleukin-1ß dilates steelhead trout coronary microvessels: effect of temperature and role of the endothelium, nitric oxide and prostaglandins

Costa

Hein

Secombes

et al. 2015

Journal of Experimental Biology

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Interleukin (IL)-1β is associated with hypotension and cardiovascular collapse in mammals during heat stroke, and the mRNA expression of this pro-inflammatory cytokine increases dramatically in the blood of Atlantic cod (Gadus morhua) at high temperatures. These data suggest that release of IL-1β at high temperatures negatively impacts fish cardiovascular function and could be a primary determinant of upper thermal tolerance in this taxa. Thus, we measured the concentration-dependent response of isolated steelhead trout (Oncorhynchus mykiss) coronary microvessels (<150 μm in diameter) to recombinant (r) IL-1β at two temperatures (10 and 20°C). Recombinant IL-1β induced a concentration-dependent vasodilation with vessel diameter increasing by approximately 8 and 30% at 10 −8 and 10, respectively. However, this effect was not temperature dependent. Both vessel denudation and cyclooxygenase blockade (by indomethacin), but not the nitric oxide (NO) antagonist L-NIO, inhibited the vasodilator effect of rIL-1β. In contrast, the concentration-dependent dilation caused by the endothelium-dependent calcium ionophore A23187 was completely abolished by L-NIO and indomethacin, suggesting that both NO and prostaglandin signaling mechanisms exist in the trout coronary microvasculature. These data: (1) are the first to demonstrate a functional link between the immune and cardiovascular systems in fishes; (2) suggest that IL-1β release at high temperatures may reduce systemic vascular resistance, and thus, the capacity of fish to maintain blood pressure; and (3) provide evidence that both NO and prostaglandins play a role in regulating coronary vascular tone, and thus, blood flow.

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Section: Vasoactivity Of Recombinant Il-1β and The Effect Of Temperaturesupporting

confidence: 74%

Section: Role Of the Endothelium No And Prostaglandins In Ril-1β-indmentioning

confidence: 41%

Section: Role Of the Endothelium No And Prostaglandins In Ril-1β-indmentioning

confidence: 99%

“…Several studies have indicated that A23187 is an endothelium-dependent vasodilator of fish vessels Park et al, 2000;Jennings et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Recombinant interleukin-1ß dilates steelhead trout coronary microvessels: effect of temperature and role of the endothelium, nitric oxide and prostaglandins

Costa

Hein

Secombes

et al. 2015

Journal of Experimental Biology

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Phylogenesis of constitutively formed nitric oxide in non-mammals

Toda¹,

Ayajiki²

2006

Reviews of Physiology Biochemistry and Pharmacology

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Mechanisms of vasodilation in the dorsal aorta of the elephant fish, Callorhinchus milii (Chimaeriformes: Holocephali)

et al. 2007

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This study investigated vasodilator mechanisms in the dorsal aorta of the elephant fish, Callorhinchus milii, using anatomical and physiological approaches. Nitric oxide synthase could only be located in the perivascular nerve fibres and not the endothelium of the dorsal aorta, using NADPH histochemistry and immunohistochemistry. In vitro organ bath experiments demonstrated that a NO/soluble guanylyl cyclase (GC) system appeared to be absent in the vascular smooth muscle, since the NO donors SNP (10(-4) mol l(-1)) and SIN-1 (10(-5) mol l(-1)) were without effect. Nicotine (3 x 10(-4) mol l(-1)) mediated a vasodilation that was not affected by ODQ (10(-5) mol l(-1)), L-NNA (10(-4) mol l(-1)), indomethacin (10(-5) mol l(-1)), or removal of the endothelium. In contrast, the voltage-gated sodium channel inhibitor, tetrodotoxin (10(-5) mol l(-1)), significantly decreased the dilation induced by nicotine, suggesting that it contained a neural component. Pre-incubation of the dorsal aorta with the calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP(8-37) (10(-6) mol l(-1)) also caused a significant decrease in the nicotine-induced dilation. We propose that nicotine is mediating a neurally-derived vasodilation in the dorsal aorta that is independent of NO, prostaglandins and the endothelium, and partly mediated by CGRP.

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Cyclooxygenase-derived products, rather than nitric oxide, are endothelium-derived relaxing factor(s) in the ventral aorta of carp (Cyprinus carpio)

Cited by 18 publications

References 24 publications

Recombinant interleukin-1ß dilates steelhead trout coronary microvessels: effect of temperature and role of the endothelium, nitric oxide and prostaglandins

Recombinant interleukin-1ß dilates steelhead trout coronary microvessels: effect of temperature and role of the endothelium, nitric oxide and prostaglandins

Phylogenesis of constitutively formed nitric oxide in non-mammals

Mechanisms of vasodilation in the dorsal aorta of the elephant fish, Callorhinchus milii (Chimaeriformes: Holocephali)

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