Cyclooxygenase blockade attenuates responses of group IV muscle afferents to static contraction

Rotto, D. M.; Hill, J. M.; Schultz, Harold D.; Kaufman, Marc P.

doi:10.1152/ajpheart.1990.259.3.h745

Cited by 53 publications

(61 citation statements)

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“…Mechanoreceptor sensitivity can be altered by a variety of factors, including prostaglandins, bradykinin, and lactic acid (6,27). Arachidonic acid derivatives have been found to selectively excite mechanoreceptors and not metaboreceptors (22,23). Therefore, it is possible that in the heating trials the increased muscle temperature may have altered the chemical milieu of the muscle and increased the concentration of a neurologically active substance that could sensitize the mechanoreceptors.…”

Section: Discussionmentioning

confidence: 99%

Changes in forearm muscle temperature alter renal vascular responses to isometric handgrip

Kuipers

Sauder²,

Kearney³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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The purpose of the present study was to examine the effect of heating and cooling the forearm muscles on renal vascular responses to ischemic isometric handgrip (IHG). It was hypothesized that heating and cooling the forearm would augment and attenuate, respectively, renal vascular responses to IHG. Renal vascular responses to IHG were studied during forearm heating at 39°C ( n = 15, 26 ± 1 yr) and cooling at 26°C ( n = 12, 26 ± 1 yr). For a control trial, subjects performed the experimental protocol while the forearm was normothermic (∼34°C). Muscle temperature (measured by intramuscular probe) was controlled by changing the temperature of water cycling through a water-perfused sleeve. The experimental protocol was as follows: 3 min at baseline, 1 min of ischemia, ischemic IHG to fatigue, and 2 min of postexercise muscle ischemia. At rest, renal artery blood velocity (RBV; Doppler ultrasound) and renal vascular conductance (RVC = RBV/mean arterial blood pressure) were not different between normothermia and the two thermal conditions. During ischemic IHG, there were greater decreases in RBV and RVC in the heating trial. However, RBV and RVC were similar during postexercise muscle ischemia during heating and normothermia. RVC decreased less during cooling than in normothermia while the subjects performed the ischemic IHG protocol. During postexercise muscle ischemia, RVC was greater during cooling than in normothermia. These results indicate that heating augments mechanoreceptor-mediated renal vasoconstriction whereas cooling blunts metaboreceptor-mediated renal vasoconstriction.

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Section: Discussionmentioning

confidence: 99%

Changes in forearm muscle temperature alter renal vascular responses to isometric handgrip

Kuipers

Sauder²,

Kearney³

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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“…For the peroneal nerve studies 11 normal volunteers (mean age 24 yr, range 20-30) and 7 bodybuilders (mean age 27 yr, range 24-31) were studied. All were in good health and none took medica-tion.…”

Section: Peroneal Nerve Recording Experimentsmentioning

confidence: 99%

“…For example, Rotto et al (7) have recently provided convincing evidence that cyclooxygenase blockade, which prevents prostaglandin and thromboxane synthesis, greatly attenuates group IV muscle afferent activity. Group IV afferents are thought to be part ofthe afferent limb of the metaboreceptor reflex arc (8).…”

Section: Introductionmentioning

confidence: 99%

Hydrogen ion concentration is not the sole determinant of muscle metaboreceptor responses in humans.

Sinoway¹,

Rea²,

Mosher³

et al. 1992

J. Clin. Invest.

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We examined the effects of exercise conditioning on muscle sympathetic nerve activity (MSNA) during handgrip and posthandgrip circulatory arrest (PHG-CA). Two conditioning stimuli were studied: forearm dominance and bodybuilding. Static handgrip at 30% maximal voluntary contraction followed by PHG-CA led to a rise in MSNA smaller in dominant than in nondominant forearms (99% vs. 222%; P < 0.02) and in body builders than in normal volunteers (28% vs. 244%; P < 0.01). Separate 31P NMR experiments showed no effect of dominance on forearm pH but a pH in bodybuilders higher (6.88) than in normal volunteers (6.79; P < 0.02) during PHG-CA.Our second goal was to determine if factors besides attenuated [H'J contribute to this conditioning effect. If differences in MSNA during exercise were noted at the same pH, then other mechanisms must contribute to the training effect. We measured MSNA during ischemic fatiguing handgrip. No dominance or bodybuilding effect on pH was noted. However, we noted increases in MSNA smaller in dominant than nondominant forearms (212% vs. 322%; P < 0.02) and in bodybuilders than in normal volunteers (161% vs. 334%; P < 0.01). In summary, MSNA responses were less during exercise of conditioned limbs. Factors aside from a lessening of muscle acidosis contribute to this effect. (J. Clin. Invest. 1992.

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“…This information is projected to the spinal cord and brain stem; eventually, sympathetic outflow increases, mean arterial pressure (MAP) increases, and heart rate (HR) increases (16). Prostanoids are produced during skeletal muscle contraction and subsequently stimulate muscle afferent nerves, thereby contributing to the exercise pressor reflex (32)(33)(34)38). Experiments in cats have demonstrated that intravenous indomethacin (a nonselective inhibitor of cyclooxygenase) attenuates group III and IV afferent nerve responses to dynamic exercise (15).…”

mentioning

confidence: 99%

Inhibition of cyclooxygenase attenuates the blood pressure response to plantar flexion exercise in peripheral arterial disease

Müller

Drew

Ross

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Muller MD, Drew RC, Ross AJ, Blaha CA, Cauffman AE, Kaufman MP, Sinoway LI. Inhibition of cyclooxygenase attenuates the blood pressure response to plantar flexion exercise in peripheral arterial disease. Am J Physiol Heart Circ Physiol 309: H523-H528, 2015. First published June 8, 2015 doi:10.1152/ajpheart.00267.2015.-Prostanoids are produced during skeletal muscle contraction and subsequently stimulate muscle afferent nerves, thereby contributing to the exercise pressor reflex. Humans with peripheral arterial disease (PAD) have an augmented exercise pressor reflex, but the metabolite(s) responsible for this augmented response is not known. We tested the hypothesis that intravenous injection of ketorolac, which blocks the activity of cyclooxygenase, would attenuate the rise in mean arterial blood pressure (MAP) and heart rate (HR) evoked by plantar flexion exercise. Seven PAD patients underwent 4 min of single-leg dynamic plantar flexion (30 contractions/min) in the supine posture (workload: 0.5-2.0 kg). MAP and HR were measured on a beat-by-beat basis; changes from baseline in response to exercise were determined. Ketorolac did not affect MAP or HR at rest. During the first 20 s of exercise with the most symptomatic leg, ⌬MAP was significantly attenuated by ketorolac (2 Ϯ 2 mmHg) compared with control (8 Ϯ 2 mmHg, P ϭ 0.005), but ⌬HR was similar (6 Ϯ 2 vs. 5 Ϯ 1 beats/min). Importantly, patients rated the exercise bout as "very light" to "fairly light," and average pain ratings were 1 of 10. Ketorolac had no effect on perceived exertion or pain ratings. Ketorolac also had no effect on MAP or HR in seven age-and sex-matched healthy subjects who performed a similar but longer plantar flexion protocol (workload: 0.5-7.0 kg). These data suggest that prostanoids contribute to the augmented exercise pressor reflex in patients with PAD. PERIPHERAL ARTERIAL DISEASE (PAD) is a form of atherosclerosis that preferentially affects the lower extremity. Because leg blood flow is impaired in PAD, it is not surprising that dynamic exercise, such as walking, provokes pain in the calf, thigh, or buttocks, termed "intermittent claudication." Clinical exercise testing (e.g., the Bruce treadmill protocol) also causes a large increase in blood pressure (BP) in PAD patients, and studies (10, 11) have linked this augmented pressor response to cardiovascular morbidity and mortality. In recent years, our laboratory has focused on BP control in patients with PAD. Specifically, we found that 1) the BP response to single-leg dynamic plantar flexion exercise was augmented in PAD patients compared with healthy control subjects; 2) the pressor response occurred at very low workloads and before the onset of pain; 3) the pressor response correlated with the anklebrachial index (ABI), suggesting that disease severity plays a role; and 4) intravenous infusion of ascorbic acid lowered the pressor response to exercise in PAD (13,28). To date, the mechanisms for these findings are largely unknown. Understanding BP regulation during exercise in PAD ...

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Cyclooxygenase blockade attenuates responses of group IV muscle afferents to static contraction

Cited by 53 publications

References 0 publications

Changes in forearm muscle temperature alter renal vascular responses to isometric handgrip

Changes in forearm muscle temperature alter renal vascular responses to isometric handgrip

Hydrogen ion concentration is not the sole determinant of muscle metaboreceptor responses in humans.

Inhibition of cyclooxygenase attenuates the blood pressure response to plantar flexion exercise in peripheral arterial disease

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