Cyclooxygenase-2 expression predicts recurrence of cervical dysplasia following loop electrosurgical excision procedure

Farley, John H.; Uyehara, Catherine F. T.; Hashiro, Glenn M; Belnap, Christina; Birrer, Michael J.; Salminen, Eric R.

doi:10.1016/j.ygyno.2003.10.052

Cited by 22 publications

(19 citation statements)

References 32 publications

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“…COX‐2 expression has been studied in loop biopsy specimens for cervical intraepithelial neoplasia (28) , and COX‐2–positive margin was found to be a prognostic factor for recurrent dysplasia in this pilot study. The assessment of COX‐1 and COX‐2 expression in previous cervical intraepithelial neoplasia biopsies and subsequent cervical tumor/stroma expression are likely to provide further information and enable the elucidation of exact role of COX expression in tumorigenesis/tumor invasion.…”

Section: Discussionmentioning

confidence: 81%

COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival

Athavale¹,

Clooney²,

O'Hagan³

et al. 2006

Int J Gynecol Cancer

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COX-1 and COX-2 are members of the cyclooxygenase (COX) family, which influence tumor invasion and apoptosis. The objective of the study was to assess the relationship between COX-1 and COX-2 expression in early-stage disease and subsequent disease relapse and long-term survival. Women with FIGO stage I and II cervical carcinoma, younger than 50 years, treated between 1981 and 1990 were included. COX-1 and COX-2 expressions in the tumors were assessed by immunohistochemistry. COX-1 and COX-2 were expressed in 61% (17/28) and 57% (16/28) of tumors, respectively. COX-1 nonexpressers showed an improved overall survival compared to expressers (log-rank test, P= 0.09). There was no significant difference in the overall survival in COX-2 nonexpressers compared to expressers (P= 0.6). Out of eight women with disease relapse, COX-1 or COX-2 expression was noted in six of eight tumors, and both were expressed in five of eight tumors. Our preliminary data suggest an adverse prognosis with COX-1 expression in early-stage cervical carcinoma and a trend toward COX-1 expression in disease relapse. The association between COX-2 expression and a worse prognosis was not proven in this study.

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Section: Discussionmentioning

confidence: 81%

COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival

Athavale¹,

Clooney²,

O'Hagan³

et al. 2006

Int J Gynecol Cancer

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“…A potential mutual activity also coactivates the corepressor with HPV16 E6 and E7 oncoproteins in a complex mechanism of mutual activation and degradation, inducing expression of COX-2. Farley et al 39 published a paper on the expression of COX-2 in precancerous cervical changes. The study included 62 cervical samples obtained by the LEEP technique (loop electrosurgical excision procedure), which included 18 CIN 1, 19 CIN 2 and 25 CIN 3 changes.…”

Section: Discussionmentioning

confidence: 99%

Cyclooxygenase-2 expression in cervical cancer

Mandić¹,

Usaj-Knezevic

Nincic

et al. 2014

VOJNOSANIT PREGL

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“…Whereas COX1 is constitutively expressed in most human tissues, COX2 is inducible upon inflammation or during tumour formation, including cervical cancer 9. Moreover, COXs catalyse the formation of prostaglandins, which in turn are lipid signalling mediators with a broad range of activities, particularly in pro-inflammatory processes 10. Sales et al 11 observed an enhanced expression of COX1 usually associated with an increase of COX2 in squamous cell carcinomas, as well as adenocarcinoma of the cervix.…”

Section: Discussionmentioning

confidence: 99%

Immune factors involved in the cervical immune response in the HIV/HPV co-infection

Nicol

Nuovo²,

Salomão-Estevez³

et al. 2007

J Clin Pathol

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Cyclooxygenase-2 expression predicts recurrence of cervical dysplasia following loop electrosurgical excision procedure

Cited by 22 publications

References 32 publications

COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival

COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival

Cyclooxygenase-2 expression in cervical cancer

Immune factors involved in the cervical immune response in the HIV/HPV co-infection

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