Cyclooxygenase‐2 Expression in Chronic Liver Diseases and Hepatocellular Carcinoma

Abstract

(a) COX-2 expression was significantly lower in HCC than in the other CLD; (b) COX-2 expression inversely correlated with tumor differentiation status. These results suggest that COX-2 expression could be related to the inflammatory phenomena present in the early phases of CLD and eventually to the induction of hepatocarcinogenesis.

Chemopreventive effect of saikosaponin-d on diethylinitrosamine-induced hepatocarcinogenesis: Involvement of CCAAT/enhancer binding protein�β and cyclooxygenase-2

“…In recent years, studies have emphasized the potential role of COX-2 in linking chronic inflammation with carcinogenesis and progression in various cancer types (4). It has been shown that COX-2 plays crucial roles in fibrogenesis and hepatocarcinogenesis (9,39). In the present study, the increase in COX-2 expression was observed in DEN-induced HCC tissues in rats, consistent with a recent report (8).…”

“…Various HCC-related molecules such as hepatitis B virus X protein (6), hepatitis C virus (7) and diethylinitrosamine (DEN) (8), have been reported to induce the expression of COX-2, which finally facilitates hepatocarcinogenesis and cancer progression. Moreover, studies have revealed that COX-2 overexpression is present in well-differentiated HCC and is an early event in the process of hepatocarcinogenesis (9,10). Deregulation of the COX-2 signaling pathway serves as a basis for designing novel-targeted therapeutic strategies for cancer therapy.…”

Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver

“…In addition, cytosolic PLA2, the principal form of PLA2 responsible for AA release from membrane phospholipids The aforementioned fi ndings are consistent with a phenotype in the Hint1 Ϫ / Ϫ liver of increased proliferative signaling with reduced proapoptotic signaling. Although infl ammation was shown to be required for diethylnitrosamine-induced liver cancer ( 45 ) and is thought to play a role in human HCC ( 46 ), no increase in prostaglandin infl ammatory mediators was found in this study; in fact, a decrease in these molecules was observed in the livers of the null mice. It is not known which components of the lipidomic phenotype of the Hint1 Ϫ / Ϫ mouse are key to cancer susceptibility in these animals.…”

Effects of silencing cyclooxygenase-2 expression via RNA interference on the tumorigenicity of the SMMC-7721 human hepatocarcinoma cell line

“…The relationship between COX-2 expression and liver cancer development has recently been well elucidated (26,27). Existing literature indicates that a COX-2-specific inhibitor could suppress tumor growth both in vitro and in an HCC animal model.…”