2009
DOI: 10.1111/j.1749-6632.2009.03698.x
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Cyclooxygenase‐2 Expression in Chronic Liver Diseases and Hepatocellular Carcinoma

Abstract: (a) COX-2 expression was significantly lower in HCC than in the other CLD; (b) COX-2 expression inversely correlated with tumor differentiation status. These results suggest that COX-2 expression could be related to the inflammatory phenomena present in the early phases of CLD and eventually to the induction of hepatocarcinogenesis.

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Cited by 44 publications
(41 citation statements)
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References 20 publications
(32 reference statements)
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“…In recent years, studies have emphasized the potential role of COX-2 in linking chronic inflammation with carcinogenesis and progression in various cancer types (4). It has been shown that COX-2 plays crucial roles in fibrogenesis and hepatocarcinogenesis (9,39). In the present study, the increase in COX-2 expression was observed in DEN-induced HCC tissues in rats, consistent with a recent report (8).…”
Section: Discussionsupporting
confidence: 82%
See 1 more Smart Citation
“…In recent years, studies have emphasized the potential role of COX-2 in linking chronic inflammation with carcinogenesis and progression in various cancer types (4). It has been shown that COX-2 plays crucial roles in fibrogenesis and hepatocarcinogenesis (9,39). In the present study, the increase in COX-2 expression was observed in DEN-induced HCC tissues in rats, consistent with a recent report (8).…”
Section: Discussionsupporting
confidence: 82%
“…Various HCC-related molecules such as hepatitis B virus X protein (6), hepatitis C virus (7) and diethylinitrosamine (DEN) (8), have been reported to induce the expression of COX-2, which finally facilitates hepatocarcinogenesis and cancer progression. Moreover, studies have revealed that COX-2 overexpression is present in well-differentiated HCC and is an early event in the process of hepatocarcinogenesis (9,10). Deregulation of the COX-2 signaling pathway serves as a basis for designing novel-targeted therapeutic strategies for cancer therapy.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, cytosolic PLA2, the principal form of PLA2 responsible for AA release from membrane phospholipids The aforementioned fi ndings are consistent with a phenotype in the Hint1 Ϫ / Ϫ liver of increased proliferative signaling with reduced proapoptotic signaling. Although infl ammation was shown to be required for diethylnitrosamine-induced liver cancer ( 45 ) and is thought to play a role in human HCC ( 46 ), no increase in prostaglandin infl ammatory mediators was found in this study; in fact, a decrease in these molecules was observed in the livers of the null mice. It is not known which components of the lipidomic phenotype of the Hint1 Ϫ / Ϫ mouse are key to cancer susceptibility in these animals.…”
Section: Discussionmentioning
confidence: 38%
“…The relationship between COX-2 expression and liver cancer development has recently been well elucidated (26,27). Existing literature indicates that a COX-2-specific inhibitor could suppress tumor growth both in vitro and in an HCC animal model.…”
Section: Discussionmentioning
confidence: 99%