Cyclooxygenase-2 (COX-2) gene polymorphism in patients withdifferentiated thyroid carcinomas in the Turkish population

Uçan, Bekir; Özbek, Mustafa; Şahi̇n, Mustafa; Kızılgül, Muhammed; Çakal, Erman

doi:10.3906/sag-1708-49

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…By inhibiting the action of phospholipase, the onset of the inflammatory process is inhibited. Besides, free arachidonic acid can be metabolized to various lipid mediators known as eicosanoids via the lipoxygenases and cyclooxygenase pathways [ 132 , 133 ]. Furthermore, arachidonic acid can be metabolized to prostaglandins and epoxyeicosatrienoic acids by cyclooxygenase-2 (COX-2) and cytochrome P450 (CYP), respectively [ 114 , 134 , 135 ].…”

Section: Anti-inflammatory Molecules Of Medicinal Plants and Mechamentioning

confidence: 99%

Plants as Sources of Anti-Inflammatory Agents

et al. 2020

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Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents.

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Section: Anti-inflammatory Molecules Of Medicinal Plants and Mechamentioning

confidence: 99%

Plants as Sources of Anti-Inflammatory Agents

et al. 2020

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“…Their results also showed no association between COX-2 SNP and the radiologic severity of RA [50]. To the best of our knowledge, this is the first study to investigate the relation between COX-2 SNP and thyroid autoimmune diseases although Uçan et al conducted a study to evaluate the association of COX-2 SNP with differentiated thyroid carcinomas and found a significant correlation between COX-2 SNP and differentiated thyroid carcinomas [51].…”

Section: Discussionmentioning

confidence: 98%

Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population

Heidari

Salimi

Rokni

et al. 2021

BioMed Research International

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Background. Grave’s disease (GD) and Hashimoto’s thyroiditis (HT) are autoimmune diseases of the thyroid gland in which genetic predisposition plays a major role in their development. Currently, the role of NLRP3 inflammasome and COX-2 has been documented in many autoimmune diseases. The purpose of the study is to delineate the impact of IL-1β (rs1143634), NLRP3 (rs3806265), and COX-2 (rs2745557) gene polymorphisms in the development of GD and HT. Methods. A total of 256 newly diagnosed patients with autoimmune thyroid disease (135 patients with HT and 121 GD patients) as case groups and 145 controls were included in the study. Results. Recessive and overdominant models showed a significant association between IL-1β rs1143634 SNP and HT development risk. The frequency of TT genotype and T allele of IL-1β rs1143634 SNP in the control group was significantly higher than the GD group. There was no significant association between NLRP3 rs3806265 polymorphism and HT and GD development. The frequency of GA genotype of COX-2 (rs2745557) in the control group was significantly higher than that in the HT group. There was no significant association between COX-2 rs2745557 genotypic and allelic distribution and GD development risk. The results revealed a significant relationship between some clinical features of HT and GD groups and SNPs studied. Conclusion. The results manifest the significant impact of IL-1β rs1143634 and COX-2 (rs2745557) SNPs and HT development and IL-1β rs1143634 SNP on GD occurrence risk. Furthermore, a significant relationship was observed between some clinical features of HT and GD groups and studied SNPs.

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