Cyclooxygenase-2 and β-Catenin as Potential Diagnostic and Prognostic Markers in Endometrial Cancer

Deng, Lin; Liang, Huaping; Han, Yi

doi:10.3389/fonc.2020.00056

Cited by 11 publications

(6 citation statements)

References 46 publications

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“…The downregulation of COX2 in colon cancer could be linked to the downregulation of the wnt/-catenin pathway by Ole [ 34 ]. Many malignancies, including gastric [ 35 ], colon [ 34 ], and endometrial [ 36 ], were linked to hyperactivation of the wnt/-catenin pathway. Because of the capacity of the wnt/-catenin pathway to activate COX2, studies on the use of non-steroidal anti-inflammatory drugs (NSAIDs) in cancer prevention and treatment have been conducted [ 37 ].…”

Section: Role Of Ole In Cancermentioning

confidence: 99%

A Comprehensive Review on the Anti-Cancer Effects of Oleuropein

Rishmawi

Haddad

Dokmak

2022

Life

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In Mediterranean cuisine and culture, olive oil and olive fruits play a significant role. Many people believe that those who consume olive oil and its fruit live longer and have a decreased risk of illness. Olive leaves were used to treat a range of diseases in ancient times, including malaria fever and lower earaches. Although it was not understood at the time what key components were responsible for these effects because they had not yet been discovered, Oleuropein is now recognized as one of the primary elements in immature olive fruits and leaves. Later research was carried out to determine the effects of this molecule, and it was determined that it functions as an antioxidant. Oleuropein consumption has aided in cancer treatment over the years, and this was assumed to be owing to its antioxidant properties. Oleuropein’s effects on cancer, however, go beyond that; it is now known that Oleuropein functions as both an anti-proliferative and an apoptotic promoter in many cancer cells. The kinetics and dosages of Oleuropein and the mechanisms behind its involvement and effects in cancer are explored in this review. Finally, the effects of Oleuropein in combination with anticancer medicines are investigated.

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Section: Role Of Ole In Cancermentioning

confidence: 99%

A Comprehensive Review on the Anti-Cancer Effects of Oleuropein

Rishmawi

Haddad

Dokmak

2022

Life

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“…Histological analysis showed significant increases in bone volume per tissue volume (BV/TV), and osteoblast number per tissue area (N.Ob/T.Ar) in the Wnt3a group than in the control group. In addition, according to literature reports, the concentration of Wnt3a in serum is about 1–2 ng/mL [ 39 , 40 ], while the Wnt3a concentration of 25–100 ng/mL is often used in the experiments of inducing osteogenic differentiation in vitro [ 41 , 42 , 43 ]. However, 40,000 ng/mL of Wnt3a was required for promoting the repair of parietal bone defects in vivo [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Functionalized 3D-Printed ST2/Gelatin Methacryloyl/Polcaprolactone Scaffolds for Enhancing Bone Regeneration with Vascularization

Liu

Chen

Wang

et al. 2022

IJMS

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Growth factors were often used to improve the bioactivity of biomaterials in order to fabricate biofunctionalized bone grafts for bone defect repair. However, supraphysiological concentrations of growth factors for improving bioactivity could lead to serious side effects, such as ectopic bone formation, radiculitis, swelling of soft tissue in the neck, etc. Therefore, safely and effectively applying growth factors in bone repair biomaterials comes to be an urgent problem that needs to be addressed. In this study, an appropriate concentration (50 ng/mL) of Wnt3a was used to pretreat the 3D-bioprinting gelatin methacryloyl(GelMA)/polycaprolactone(PCL) scaffold loaded with bone marrow stromal cell line ST2 for 24 h. This pretreatment promoted the cell proliferation, osteogenic differentiation, and mineralization of ST2 in the scaffold in vitro, and enhanced angiogenesis and osteogenesis after being implanted in critical-sized mouse calvarial defects. On the contrary, the inhibition of Wnt/β-catenin signaling in ST2 cells reduced the bone repair effect of this scaffold. These results suggested that ST2/GelMA/PCL scaffolds pretreated with an appropriate concentration of Wnt3a in culture medium could effectively enhance the osteogenic and angiogenic activity of bone repair biomaterials both in vitro and in vivo. Moreover, it would avoid the side effects caused by the supraphysiological concentrations of growth factors. This functionalized scaffold with osteogenic and angiogenic activity might be used as an outstanding bone substitute for bone regeneration and repair.

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“…β-catenin is also an important intracellular transducer in the Wnt pathway, which is associated with the majority of human malignancies with aberrant activation. 14 Some studies have suggested that β-catenin concentrations are decreased in endometriotic lesions compared with those in the normal proliferative endometrium, and over-activation of the β-catenin pathway is associated with development of endometriosis. 15 We found that β-catenin staining was preserved in patients with nonrecurrent endometriosis and was typically present in the cytoplasm and cell membrane of glandular epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Expression of cellular adherent and invasive molecules in recurrent ovarian endometriosis

Zhang

Jiang³

et al. 2020

J Int Med Res

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Objective This study aimed to examine expression of cellular adhesion molecules and metalloproteinases of the extracellular matrix in ectopic endometrium for evaluating their roles in recurrence of endometriosis. Methods This study retrospectively analyzed 49 female patients (mean age: 30.1±5.5 years) with endometriomas who had undergone two separate operations. After a maximum follow-up of 80 months, all participants were divided into the recurrent group or nonrecurrent (control) group. Samples were immunostained for epithelial cadherin (E-cadherin), β-catenin, urokinase plasminogen activator (uPA), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-2, and extracellular matrix metalloproteinase inducer (EMMPRIN). Results In the recurrent group, E-cadherin concentrations in the membrane and cytoplasm of ectopic endometrial glandular cells were significantly reduced, while those of MMP-9 and EMMPRIN were higher than those in the control group. Additionally, uPA concentrations in the membrane and cytoplasm of ectopic endometrial glandular, stromal, and vascular endothelial cells were significantly higher in the recurrent group than in the control group. Tissue inhibitor of matrix metalloproteinase-2 and β-catenin concentrations were similar between the groups. Conclusion E-cadherin, MMP-9, and associated factors may contribute to development of endometriosis. E-cadherin, MMP-9, and uPA may act as potential markers for detection of recurrence of endometriosis.

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Cyclooxygenase-2 and β-Catenin as Potential Diagnostic and Prognostic Markers in Endometrial Cancer

Cited by 11 publications

References 46 publications

A Comprehensive Review on the Anti-Cancer Effects of Oleuropein

A Comprehensive Review on the Anti-Cancer Effects of Oleuropein

Functionalized 3D-Printed ST2/Gelatin Methacryloyl/Polcaprolactone Scaffolds for Enhancing Bone Regeneration with Vascularization

Expression of cellular adherent and invasive molecules in recurrent ovarian endometriosis

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