Cyclooxygenase-2-1195g&gt;A Polymorphism Is Associated With Chronic Obstructive Pulmonary Disease In Japanese And Chinese Population

Chen, Lijun; Taooka, Yasuyuki; Okimoto, Tamio; Iwamoto, Shinichi; Karino, Fumi; Tsubata, Yukari; Miura, Kiyonori; Suzuki, Taeko; Hamaguchi, Shunichi; Tada, Mitsuhiro; Kanda, Hideaki; Sutani, Akihisa; Kuraki, Takashige; Isobe, Takeshi

doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1761

Cited by 3 publications

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“…In addition, there are differences in COX-2 expression levels between people of different demographic characteristics, which leads to disparities in aspirin sensitivity [ 59 , 60 ]. Furthermore, while taking aspirin, distinct net clinical benefits were identified between people of different demographic characteristics which might be due to variations in pharmacokinetic and pharmacodynamic profiles [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis

Sun

et al. 2022

Eur J Clin Pharmacol

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Purpose The coronavirus disease 2019 (COVID-19) pandemic has shown unprecedented impact world-wide since the eruption in late 2019. Importantly, emerging reports suggest an increased risk of thromboembolism development in patients with COVID-19. Meanwhile, it is found that aspirin reduced mortality in critically ill patients with non-COVID-19 acute respiratory distress syndrome. Therefore, a meta-analysis was performed to investigate the effects of aspirin on COVID-19 mortality. Methods A systematic literature search was conducted in 10 electronic databases and 4 registries. Random effects models were used to calculate pooled relative risks (RRs) with 95% confidence intervals (Cis) to estimate the effect of aspirin on COVID-19 mortality. Relevant subgroup analyses and sensitivity analyses were also performed. Results The results showed that aspirin use was associated with a reduction in COVID-19 mortality (adjusted RR 0.69; 95% CI 0.50–0.95; P < 0.001). Subgroup analysis found that the low-dose group was associated with a reduced COVID-19 mortality (adjusted RR 0.64; 95% CI 0.48–0.85; P < 0.01). Aspirin use was associated with reduced COVID-19 mortality in Europe and America (crude RR 0.71; 95% CI 0.52–0.98; P = 0.04), and results from cohort studies suggested that aspirin use was a protective factor for COVID-19 mortality (adjusted RR 0.73; 95% CI 0.52–0.99; P = 0.04). Meanwhile, aspirin use was not associated with bleeding risk (crude RR 1.22; 95% CI 0.80–1.87; P = 0.96). Conclusions This meta-analysis found that aspirin use was associated with a reduction in mortality in patients with COVID-19 and not with an increased risk of bleeding. Supplementary information The online version contains supplementary material available at 10.1007/s00228-022-03356-5.

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Section: Discussionmentioning

confidence: 99%

Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis

Sun

et al. 2022

Eur J Clin Pharmacol

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“…We previously demonstrated that the homozygous COX-2 –1195A genotype increased the risk for COPD in Japanese individuals ( Chen et al, 2013 ). A Swedish study showed that the association with a lower FEV1 was higher for patients with lung squamous cell carcinoma than those with lung adenocarcinoma ( Purdue et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

“…Three single nucleotide polymorphisms (SNPs) of the potential function, –1290G/A (rs689465), –1195G/A (rs689466), and –765G/C (rs20417), were identified in the COX-2 gene in esophageal cancer ( Zhang et al, 2005 ). We previously reported that the homozygous COX-2 –1195A genotype is associated with an increased risk for chronic obstructive pulmonary disease (COPD) in the Japanese population ( Chen et al, 2013 ). COPD is the single risk factor identified for the development of lung cancer after smoking exposure ( Young et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Cyclooxygenase-2 –1195G/A (rs689466) Gene Polymorphism and the Clinicopathology of Lung Cancer in the Japanese Population: A Case-Controlled Study

et al. 2022

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The single nucleotide polymorphisms of COX-2 gene, also known as PTGS2, which encodes a pro-inflammatory factor cyclooxygenase-2, alter the risk of developing multiple tumors, but these findings are not consistent for lung cancer. We previously reported that the homozygous COX-2 –1195A genotype is associated with an increased risk for chronic obstructive pulmonary disease (COPD) in Japanese individuals. COPD is a significant risk factor for lung cancer due to genetic susceptibility to cigarette smoke. In this study, we investigated the association between COX-2 –1195G/A polymorphism and lung cancer susceptibility in the Japanese population. We evaluated the genotype distribution of COX-2 –1195G/A using a polymerase chain reaction-restriction fragment length polymorphism assay for 330 newly diagnosed patients with lung cancer and 162 healthy controls. Our results show that no relationship exists between the COX-2 –1195G/A polymorphism and the risk of developing lung cancer. However, compared to the control group, the homozygous COX-2 –1195A genotype increased the risk for lung squamous cell carcinoma (odds ratio = 2.902; 95% confidence interval, 1.171–7.195; p = 0.021), whereas no association is observed with the risk for adenocarcinoma. In addition, Kaplan-Meier analysis shows that the genotype distribution of homozygous COX-2 –1195A does not correlate with the overall survival of patients with lung squamous cell carcinoma. Thus, we conclude that the homozygous COX-2 –1195A genotype confers an increased risk for lung squamous cell carcinoma in Japanese individuals and could be used as a predictive factor for early detection of lung squamous cell carcinoma.

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“…The human COX-2 gene is located on chromosome 1 locus of 1q25.2–q25.3 and is 8.0 kbp in size with 10 exons [ 12 ]. COX-2 gene polymorphisms affect the expression levels and enzymatic activity of COX-2 and therefore are intimately linked to inflammatory response and individual variations in the susceptibility to oral cancers [ 13 – 15 ]. Three single-nucleotide polymorphisms (SNPs) in the COX-2 gene, −1195 G > A (reference SNP ID, rs689466), +837 T > C (rs5275), and −765 G > C (rs20417) have received considerable attention for their close links to oral cancers, compared to the other SNPs of COX-2 gene [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Functional Polymorphisms inCOX-2Gene Are Correlated with the Risk of Oral Cancer

Liu

Hao

Sun

et al. 2015

BioMed Research International

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Background. This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer. Methods. Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software. Results. We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers. Conclusion. Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and −765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.

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Cyclooxygenase-2-1195g>A Polymorphism Is Associated With Chronic Obstructive Pulmonary Disease In Japanese And Chinese Population

Cited by 3 publications

References 0 publications

Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis

Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis

The Association Between Cyclooxygenase-2 –1195G/A (rs689466) Gene Polymorphism and the Clinicopathology of Lung Cancer in the Japanese Population: A Case-Controlled Study

Functional Polymorphisms inCOX-2Gene Are Correlated with the Risk of Oral Cancer

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