Cyclooxygenase-1-Derived Prostaglandins in the Periaqueductal Gray Differentially Control C- versus A-Fiber-Evoked Spinal Nociception

Leith, J. Lianne; Wilson, A. C. M.; Donaldson, Lucy F.; Lumb, Bridget M.

doi:10.1523/jneurosci.2586-07.2007

Cited by 41 publications

(69 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed clinical effect of simple migraine treatment in our patients supports the existence of central targets of triptans,13 and perhaps also non-steroidal anti-inflammatory drugs,14 in brainstem areas such as the periaqueductal grey, which is modulates both the trigeminovascular system and arousal networks. In addition, domperidone may independently modulate the evolution of a migraine with aura attack when taken early during the premonitory phase,15 although the mechanism of this observed effect is unclear.…”

Section: Discussionsupporting

confidence: 80%

Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome)

Nesbitt

Leschziner

2016

Pract Neurol

View full text Add to dashboard Cite

Recurrent hypersomnia, or Kleine-Levin syndrome, is rare and frequently causes substantial diagnostic anxiety and delay. Patients often undergo multiple investigations to rule out other causes of encephalopathy. The treatment options are unsatisfactory. Migraine with brainstem aura has not previously been widely considered in the medical literature as a differential diagnosis. We describe two patients referred to a tertiary sleep neurology service with a putative diagnosis of Kleine-Levin syndrome. Each described attacks of hypersomnia with elements of migraine with brainstem aura, in addition to having a history of migraine with aura. Simple acute migraine treatment clearly attenuated further attacks. These cases generate discussion as to the common features and potential mechanisms underlying both disorders. Furthermore, they highlight a hitherto underexplored alternative diagnosis of Kleine-Levin syndrome. This provides scope for offering established and effective migraine treatment options to patients who with a potential misdiagnosis of Kleine-Levin syndrome, providing scope for offering established and effective migraine treatment to some patients originally diagnosed with a rare condition for which there is no current consistently effective therapeutic options.

show abstract

Section: Discussionsupporting

confidence: 80%

Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome)

Nesbitt

Leschziner

2016

Pract Neurol

View full text Add to dashboard Cite

show abstract

“…It is believed that COX-1 is constitutive and COX-2 is inducible, and both types are important in mediation of pain, inflammation and fever (Vane et al, 1998; Hoffmann, 2000; Bennett, 2001; Bertolini et al, 2002; Burian and Geisslinger, 2005). Spinal COX-1 and COX-2 have been demonstrated to participate in facilitation of neurotransmitter release from primary afferents to the dorsal horn that can alter synaptic transmission (Kaufmann et al, 1997; Hoffmann, 2000; Vanegas and Schaible, 2001; Leith et al, 2007; Li et al, 2009). Inhibition of spinal COXs was achieved by i.t.…”

Section: Nociceptive and Inflammatory Effects Of Subcutaneous Bee mentioning

confidence: 99%

The nociceptive and anti-nociceptive effects of bee venom injection and therapy: A double-edged sword

Chen

Lariviere

2010

Progress in Neurobiology

156

121

View full text Add to dashboard Cite

Bee venom injection as a therapy, like many other complementary and alternative medicine approaches, has been used for thousands of years to attempt to alleviate a range of diseases including arthritis. More recently, additional theraupeutic goals have been added to the list of diseases making this a critical time to evaluate the evidence for the beneficial and adverse effects of bee venom injection. Although reports of pain reduction (analgesic and antinociceptive) and anti-inflammatory effects of bee venom injection are accumulating in the literature, it is common knowledge that bee venom stings are painful and produce inflammation. In addition, a significant number of studies have been performed in the past decade highlighting that injection of bee venom and components of bee venom produce significant signs of pain or nociception, inflammation and many effects at multiple levels of immediate, acute and prolonged pain processes. This report reviews the extensive new data regarding the deleterious effects of bee venom injection in people and animals, our current understanding of the responsible underlying mechanisms and critical venom components, and provides a critical evaluation of reports of the beneficial effects of bee venom injection in people and animals and the proposed underlying mechanisms. Although further studies are required to make firm conclusions, therapeutic bee venom injection may be beneficial for some patients, but may also be harmful. This report highlights key patterns of results, critical shortcomings, and essential areas requiring further study.

show abstract

“…Descending control originating in the PAG has been shown to powerfully modulate withdrawal reflexes evoked by noxious mechanical and thermal (heat) stimuli (e.g., Mayer et al, 1971;Fardin et al, 1984;Carstens et al, 1990;McMullan and Lumb, 2006a;Leith et al, 2007). However whether this control extends to noxious cold stimulation remains unclear; therefore, the effect of VL-PAG stimulation on cold-evoked withdrawal thresholds and response magnitudes was investigated.…”

Section: Cold-evoked Withdrawal Reflexes Are Significantly Depressed mentioning

confidence: 99%

Spinal Processing of Noxious and Innocuous Cold Information: Differential Modulation by the Periaqueductal Gray

Leith¹,

Koutsikou²,

Lumb³

et al. 2010

J. Neurosci.

Self Cite

View full text Add to dashboard Cite

In addition to cold being an important behavioral drive, altered cold sensation frequently accompanies pathological pain states. However, in contrast to peripheral mechanisms, central processing of cold sensory input has received relatively little attention. The present study characterized spinal responses to noxious and innocuous intensities of cold stimulation in vivo and established the extent to which they are modulated by descending control originating from the periaqueductal gray (PAG), a major determinant of acute and chronic pain. In lightly anesthetized rats, hindpaw cooling with ethyl chloride, but not acetone, was sufficiently noxious to evoke withdrawal reflexes, which were powerfully inhibited by ventrolateral (VL)-PAG stimulation. In a second series of experiments, subsets of spinal dorsal horn neurons were found to respond to innocuous and/or noxious cold. Descending control from the VL-PAG distinguished between activity in nociceptive versus non-nociceptive spinal circuits in that innocuous cold information transmitted by non-nociceptive class 1 and wide-dynamic-range class 2 neurons remained unaltered. In contrast, noxious cold information transmitted by class 2 neurons and all cold-evoked activity in nociceptive-specific class 3 neurons was significantly depressed. We therefore demonstrate that spinal responses to cold can be powerfully modulated by descending control systems originating in the PAG, and that this control selectively modulates transmission of noxious versus innocuous information. This has important implications for central processing of cold somatosensation and, given that chronic pain states are dependent on dynamic alterations in descending control, will help elucidate mechanisms underlying aberrant cold sensations that accompany pathological pain states.

show abstract

Cyclooxygenase-1-Derived Prostaglandins in the Periaqueductal Gray Differentially Control C- versus A-Fiber-Evoked Spinal Nociception

Cited by 41 publications

References 73 publications

Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome)

Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome)

The nociceptive and anti-nociceptive effects of bee venom injection and therapy: A double-edged sword

Spinal Processing of Noxious and Innocuous Cold Information: Differential Modulation by the Periaqueductal Gray

Contact Info

Product

Resources

About