Cycloheximide induced amnesia: Its interaction with detention

Abstract

Abstract. After training in a passive avoidance task, mice were detained in the safe compartment of the conditioning apparatus: This detention produced an impairment of rentention on the retest trial.Detention did not prolong the cycloheximide susceptible phase of memory formation. A summation of the amnestic effects of the two treatments occurred only at a time when both were effective alone. Cycloheximide was without effect upon the detention experience itself.

Amnesia, consolidation, and retrieval.

“…Davis and Klinger (1969) and Davis and Hirtzel (1970), using goldfish, observed that detention potentiated the amnesia produced by KC1, puromycin, acetoxycycloheximide, and electroconvulsive shock. And Geller, Robustelli, and Jarvik (1971) found that posttraining detention of mice produces a memory deficit that is additive to one produced by cycloheximide.…”

“…The potentiation of memory deficits produced by amnestic agents administered immediately after detention is thought by some to be an interaction of detention and the amnestic agent (e.g., Davis & Hirtzel, 1970;Davis & Klinger, 1969) while others regard the two decremental effects as merely additive (e.g., Geller, Robustelli, & Jarvik, 1971). However, other studies by the latter investigators have yielded data suggesting a strong interaction (Robustelli, Geller, & Jarvik, 1968).…”

Amnesic effect of cycloheximide in the mouse mediated by adrenocortical hormones.

“…Cycloheximide has an amnesic effect. Mice subcutaneously injected with this drug shortly before or immediately after a training trial of a passive avoidance task fail to show the learned response at a later time (Andry & Luttges, 1972;Flood, Bennett, Rosenzweig, & Orme, 1972, 1973Geller, 1971;Geller, Robustelli, Barondes, & Cohen, 1969;Geller, Robustelli, & Jarvik, 1970;Quartermain & McEwen, 1970;Quartermain, McEwen, & Azmitia, 1970Quinton, 1971;Randt, McEwen, & Quartermain, 1971). The amnesic effect has been thought to result from suppression of protein synthesis in the brain at the time of training.…”

Protein Synthesis and Memory

“…The first point has been confirmed by numerous studies (Flood, Bennett, Rosenzweig, & Orme, 1972;Geller, Robustelli, & Jarvik, 1971;Schmaltz & Delerm, 1974;Squire & Barondes, 1972). Flood et al (1972), for example, analyzed with precision the parameters able to affect the degree of amnesia in cycloheximide-treated mice (shock intensity, shock duration, original latency to enter the shock compartment, retention interval), in a one-trial, step-through, passive avoidance task.…”