Cyclodextrins-modified metallic nanoparticles for effective cancer therapy

Gandhi, Sahil Sandesh; Shende, Pravin

doi:10.1016/j.jconrel.2021.09.025

Cited by 36 publications

(20 citation statements)

References 73 publications

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“…The mechanism of CDs depends on the formation of inclusion complexes with, or in, organic molecules due to their unique chemical structures which look similar to truncated cones, with external surfaces having hydrophilic properties, and the internal surface having hydrophobic properties [21,22]. Therefore, CDs can be used as targeting agents and in drug-carrier applications [23].…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

et al. 2022

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Polymers and their composites have recently attracted attention in both pharmaceutical and biomedical applications. Polyethylene glycol (PEG) is a versatile polymer extensively used in medicine. Herein, three novel PEG-based polymers that are pseudopolyrotaxane (PEG/α-CD) (1), titania–nanocomposite (PEG/TiO2NPs) (2), and pseudopolyrotaxane–titania–nanocomposite (PEG/α-CD/TiO2NPs) (3), were synthesized and characterized. The chemical structure, surface morphology, and optical properties of the newly materials were examined by FT-IR, 1H-NMR, SEM, and UV–Vis., respectively. The prepared polymers were used as drug carriers of sulfaguanidine as PEG/α-CD/Drug (4), PEG/TiO2NPs/Drug (5), and PEG/α-CD/TiO2NPs/Drug (6). The influence of these drug-carrying formulations on the physical and chemical characteristics of sulfaguanidine including pharmacokinetic response, solubility, and tissue penetration was explored. Evaluation of the antibacterial and antibiofilm effect of sulfaguanidine was tested before and after loading onto the prepared polymers against some Gram-negative and positive bacteria (E. coli, Pseudomonas aeruginosa, and Staphylococcus aureus (MRSA)), as well. The results of this work turned out to be very promising as they confirmed that loading sulfaguanidine to the newly designed polymers not only showed superior antibacterial and antibiofilm efficacy compared to the pure drug, but also modified the properties of the sulfaguanidine drug itself.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

et al. 2022

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“…Such nanosystems have been proven to enhance in vivo stability, increase drug accumulation in the tumor site, improve the therapeutic effectiveness of carried drugs, and reduce systemic toxicity. Moreover, they can ensure sustained/programmable or ondemand drug release by responding to internal or external stimuli, respectively [128][129][130].…”

Section: Drug Deliverymentioning

confidence: 99%

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

et al. 2022

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Cancer continues to represent a global health concern, imposing an ongoing need to research for better treatment alternatives. In this context, nanomedicine seems to be the solution to existing problems, bringing unprecedented results in various biomedical applications, including cancer therapy, diagnosing, and imaging. As numerous studies have uncovered the advantageous properties of various nanoscale metals, this review aims to present metal-based nanoparticles that are most frequently employed for cancer applications. This paper follows the description of relevant nanoparticles made of metals, metal derivatives, hybrids, and alloys, further discussing in more detail their potential applications in cancer management, ranging from the delivery of chemotherapeutics, vaccines, and genes to ablative hyperthermia therapies and theranostic platforms.

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“…In addition, nanoparticles can specifically control drug release through surface modification, effectively reduce the therapeutic dose and administration frequency, and further reduce the cytotoxicity and adverse reactions of chemotherapeutic drugs. For example, some nanoparticles could be transferred to tumour tissues in vivo through a magnetic field and then respond to acidic tumour environment for releasing loaded drugs ( 96 ). More importantly, combining anti-angiogenic therapies with other targeted therapeutic drugs and/or immunotherapy could effectively reduce resistances by blocking their occurrence mechanism.…”

Section: Anti-angiogenic Nanoparticles In Digestive Tumoursmentioning

confidence: 99%

Opportunities and Challenges of Nanoparticles in Digestive Tumours as Anti-Angiogenic Therapies

et al. 2022

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Digestive tumours, a common kind of malignancy worldwide, have recently led to the most tumour-related deaths. Angiogenesis, the process of forming novel blood vessels from pre-existing vessels, is involved in various physiological and pathological processes in the body. Many studies suggest that abnormal angiogenesis plays an important role in the growth, progression, and metastasis of digestive tumours. Therefore, anti-angiogenic therapy is considered a promising target for improving therapeutic efficacy. Traditional strategies such as bevacizumab and regorafenib can target and block the activity of proangiogenic factors to treat digestive tumours. However, due to resistance and some limitations, such as poor pharmacokinetics, their efficacy is not always satisfactory. In recent years, nanotechnology-based anti-angiogenic therapies have emerged as a new way to treat digestive tumours. Compared with commonly used drugs, nanoparticles show great potential in tumour targeted delivery, controlled drug release, prolonged cycle time, and increased drug bioavailability. Therefore, anti-angiogenic nanoparticles may be an effective complementary therapy to treat digestive tumours. In this review, we outline the different mechanisms of angiogenesis, the effects of nanoparticles on angiogenesis, and their biomedical applications in various kinds of digestive tumours. In addition, the opportunities and challenges are briefly discussed.

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Cyclodextrins-modified metallic nanoparticles for effective cancer therapy

Cited by 36 publications

References 73 publications

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

Design, Synthesis and Evaluation of Novel Antimicrobial Polymers Based on the Inclusion of Polyethylene Glycol/TiO2 Nanocomposites in Cyclodextrin as Drug Carriers for Sulfaguanidine

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

Opportunities and Challenges of Nanoparticles in Digestive Tumours as Anti-Angiogenic Therapies

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