Cyclodextrins in capillary electrophoresis: Recent developments and new trends

Enantioresolution in electrokinetic chromatography-complete filling technique using sulfated gamma-cyclodextrin. Software-free topological anticipation

“…In the case of charged CDs, ionic interactions will also contribute or may even dominate the complexation mechanism. The interaction between oppositely charged solutes and CDs often allow the use of very low selector concentrations in enantioseparations [6,7].…”

“…Among the chiral selectors used in CE, cyclodextrins (CDs) are the most popular due to their good enantiorecognition abilities [6]. Hydrogen bonding, dipole-dipole and steric factors are believed to be involved in enantiomer-CD complexation.…”

Chiral Separation of the Enantiomers of Omeprazole and Pantoprazole by Capillary Electrophoresis

“…Another advantage of CE is that direct separation can usually be achieved simply by adding the chiral selector to the background electrolyte (BGE). The chiral selectors most frequently used in CE are, without doubt, the CD; a wide number of CD, including native and derivatized, charged and uncharged, are currently available and used in CE analysis [7].…”

Inclusion excluded: Chiroptical sensing of the external surface of sulfated cyclodextrins

“…Attached to the hydroxyl sites of the macrocycle, sulfate moieties can form hydrogen and ionic bonds with guest compounds. Despite of the combination of polar and hydrophobic cavity interactions, inclusion complexes of sulfated CDXs are featured with low-stability (K a ~ 10 1 -10 3 M -1 ) and low capacity [2][3][4][5].…”