Cyclodextrins as Complexation Agents to Improve the Anti-inflammatory Drugs Profile: a Systematic Review and Meta-Analysis

Santos, Priscila L.; Brito, Renan Guedes de; Quintans, Jullyana S. S.; Araújo, Adriano A. S.; Menezes, Irwin R.A.; Brogden, Nicole K.; Quintans‐Júnior, Lucindo J.

doi:10.2174/1381612823666170126121926

Cited by 32 publications

(21 citation statements)

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“…Cicladol is a complex molecule containing 20 mg of oxicam (Piroxicam) incorporated by a cyclic oligosaccharide β-cyclodextrin. Further, to reduce irritation of the gastro-intestinal tract, inclusion complexation with β-cyclodextrin also enhances the solubility and bioavailability of low-soluble drugs, especially for analgesic and anti-inflammatory drugs commonly used in therapeutics (17,18). It has been reported that Cicladol has a rapid adsorption rate (15 to 30 min) and analgesic effect (21).…”

Section: Discussionmentioning

confidence: 99%

“…Cicladol (piroxicam incorporated with β-cyclodextrin) has been shown to be effective in the treatment of pain related to acute inflammation due to the improved bioavailability and pharmacological efficacy obtained with cyclodextrin (16). β-Cyclodextrin is known to enhance the analgesic and anti-inflammatory effect of NSAIDs by producing an improvement in oral bioavailability, reducing effective doses to produce pharmacological activity and attenuating at least some of the side effects (17,18). Moreover, piroxicam is effective over bradykinin and substance P (18) and can be administered as a single dose for the control of postoperative pain because of its long duration of action (19).…”

Section: Introductionmentioning

confidence: 99%

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Preemptive Use of Piroxicam on Tooth Sensitivity Caused By In-Office Bleaching: A Randomized Clinical Trial

et al. 2019

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This clinical trial evaluated the effect of preemptive use of the non-steroidal anti-inflammatory drug piroxicam in a single dose 30 min prior to in-office bleaching on the prevention of tooth sensitivity (TS) reported by patients. Fifty patients were submitted to two sessions of in-office tooth bleaching with 35% hydrogen peroxide used for 2 sessions, each consisting of a single 45-min application, with an interval of 7 days between session. Thirty minutes prior to the procedure, the patient randomly received a single dose of piroxicam (200 mg) or placebo in a double-blind, randomized, crossover design. The TS was evaluated using verbal rate (VRS) and visual analog (VAS) scales during the bleaching procedure and at 24 h after each session. The color changes were assessed by the Vita Bleachedguide scale 1 week after each bleaching session. Risk of TS was calculated from the VRS and analyzed by the McNemar test, while the level of TS was analyzed by the Mann-Whitney test. For the VAS, t-tests were used to compare data from the treatments at each assessment time. Data regarding color changes were subjected to Wilcoxon and Mann-Whitney tests (α=0.05). The preemptive administration of piroxicam did not affect the risk and level of TS compared to placebo, irrespective of the assessment time. The treatment sequence did not affect bleaching effectiveness. In conclusion, the administration of a single dose of piroxicam prior to in-office tooth bleaching was unable to significantly reduce the risk and level of TS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preemptive Use of Piroxicam on Tooth Sensitivity Caused By In-Office Bleaching: A Randomized Clinical Trial

et al. 2019

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“…The possible benefits of the complexation of apolar compounds (such as terpenes) with CDs have been explored by the pharmaceutical industry and by researchers seeking improvements in pharmacological properties such as increased bioavailability, efficacy, and optimization of therapeutic doses (which reduces toxicity and adverse effects) [75,76]. Clinical and preclinical evidence has shown that the pharmacological effects of analgesic and anti-inflammatory drugs are improved when complexed with CDs [76][77][78].…”

Section: Discussion Of Unusual Topics In Fibromyalgiamentioning

confidence: 99%

“…Clinical and preclinical evidence has shown that the pharmacological effects of analgesic and anti-inflammatory drugs are improved when complexed with CDs [76][77][78].…”

Section: Discussion Of Unusual Topics In Fibromyalgiamentioning

confidence: 99%

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Brito¹,

Santos²,

AlmeidaOliveira³

et al. 2018

Discussions of Unusual Topics in Fibromyalgia

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Fibromyalgia (FM) is the second most common rheumatologic disorder, affecting 5% of the world population, and has a serious effect on the quality of life of patients, as well as an economic impact through lost workdays. This pain syndrome is a common cause of chronic widespread pain and is characterized by reduced pressure pain thresholds with hyperalgesia and allodynia, nonrestorative sleep, fatigue, cognitive dysfunction, and mood disturbances. The pharmacological treatment strategies for FM include the use of antidepressants, calcium channel modulators, muscle relaxants, and analgesics but have shown limited efficacy and therapeutic adherence. Thus, researchers have been seeking potential substances (new chemical entities or through drug repositioning) that could be used for FM treatment. In this context, natural products (NPs) have been shown to be promising pharmacological tools due to the variety of their pharmacological activity and the number of molecular sites available as possible active targets. Recent clinical and preclinical studies have been conducted to verify the possible applicability of NPs such as essential oils (EOs), plants extracts, terpenes, sapogenins, and alkaloids in the treatment of FM. The results have shown that natural products have an analgesic effect in different animal models of FM, probably by activation of inhibitory descending pathways, such as the periaqueductal gray and rostroventromedial medulla. Natural products and their secondary metabolites could therefore be a promising source for FM management. However, translational studies that seek to validate the preclinical studies are scarce, incipient, and lacking an approach focused on the traditional pharmaceutical market.

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“…The complexation in cyclodextrin is an important strategy of the drug delivery system. These complexations can promote better bioavailability [5,6] with the reduction of the effective dose and, consequently, low collateral effects [7].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Physicochemical Characterization of the Croton rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin

Martins

Wanderley

Alcântara

et al. 2020

Biology

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Croton rhamnifolioides is used in popular medicine for the treatment of inflammatory diseases. The objective of this study was to characterize and evaluate the anti-inflammatory effect of C. rhamnifolioides essential oil complexed in β-cyclodextrin (COEFC). The physicochemical characterization of the complexes was performed using different physical methods. The anti-inflammatory activity was evaluated in vivo by ear edema, paw edema, cotton pellet-induced granuloma, and vascular permeability by Evans blue extravasation. The mechanism of action was validated by molecular docking of the major constituent into the cyclooxygenase-2 (COX-2 enzyme). All doses of the COEFC reduced acute paw edema induced by carrageenan and dextran, as well as vascular permeability. Our results suggest the lowest effective dose of all samples inhibited the response induced by histamine or arachidonic acid as well as the granuloma formation. The complexation process showed that the pharmacological effects were maintained, however, showing similar results using much lower doses. The results demonstrated an involvement of the inhibition of pathways dependent on eicosanoids and histamine. Complexation of β-cyclodextrin/Essential oil (β-CD/EO) may present an important tool in the study of new compounds for the development of anti-inflammatory drugs.

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Cyclodextrins as Complexation Agents to Improve the Anti-inflammatory Drugs Profile: a Systematic Review and Meta-Analysis

Abstract: The use of CDs can improve the action of anti-inflammatory compounds and it can also be a way to reduce the side effects, therapeutic doses and toxicity.

Cited by 32 publications

References 0 publications

Preemptive Use of Piroxicam on Tooth Sensitivity Caused By In-Office Bleaching: A Randomized Clinical Trial

Preemptive Use of Piroxicam on Tooth Sensitivity Caused By In-Office Bleaching: A Randomized Clinical Trial

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Anti-Inflammatory and Physicochemical Characterization of the Croton rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin

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