Cyclodextrins and enantiomeric separations of drugs by liquid chromatography and capillary electrophoresis: basic principles and new developments

Bressolle, Françoise; Audran, Michel; Pham, T.T.H.; Vallon, J.J.

doi:10.1016/s0378-4347(96)00263-0

Cited by 162 publications

(70 citation statements)

References 187 publications

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“…o og and Gazdag [22] reported the use of chiral dervivatization reagents for biomedical chromatography. Bressolle et al gave an specialized overview of the use of cyclodextrins for chiral analysis in HPLC and CE including applications to biological fluids [71]. Comprehensive reviews dealing with the chiral analysis of drug enantiomers and their metabolites by CE and applications to pharmacokinetic studies have recently been published by Bojarski and Aboul-Enein [554] and by Zaugg and Thorman [555].…”

Section: Chiral Analysis Of Drugs In Biological Fluidsmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

223

135

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This review gives a survey of different chiral separation principles and their use in high-performance liquid chromatography (HPLC), gas chromatography (GC), supercritical fluid chromatography (SFC), thin-layer chromatography (TLC), capillary electrophoresis (CE) and capillary electrochromatography (CEC) highlighting new developments and innovative techniques. The mechanisms of the different separation principles are briefly discussed and some selected applications are shown.

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Section: Chiral Analysis Of Drugs In Biological Fluidsmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

223

135

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“…1987: Allegre and Deratani. 1994 : Bressolle et al 1996). The inclusion of the drug may have several advantages.…”

mentioning

confidence: 99%

Antiproliferative effect of methyl-β-cyclodextrin in vitro and in human tumour xenografted athymic nude mice

Grosse

Bressolle²,

Pinguet³

1998

Br J Cancer

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Summary The anti-tumour actvity of methyl-p-cyckxdextrin (MEBCD), a cydic oligosaccharide known for its interaction with the plasma membrane, was investigated in vitro and in vivo and compared with that of doxorubicin (DOX) in the human tumour models MCF7 breast carcinoma and A2780 ovanan carcinoma. In vitro proliferation was assessed using the MTT assay. In vivo studies were carmied out using xenografted Swiss nude mice injected weeldy i.p. with MEBCD at 300 or 800 mg kg-, or DOX at 2 mg kg-', durng 2 months. Undrer these conditions, MEBCD was active against MCF7 and A2780 cell lines and tumour xenografts. For each tumour model, the tumoral volume of the xenografted mice treated with MEBCD was at least twofold reduced compared wit the control group. In the MCF7 model, MEBCD (800 mg kg-') was more active than DOX (2 mg kg-1). After 56 days of treatnent with MEBCD, no toxicologically meaningful differences were observed in macroscopic and microscopic parameters compared with controls. The accumulation of MEBCD in normal and tumour tssues was also assessed using a chromatographic method. Results indicated that after a single injection of MEBCD, tumour, liver and kidneys accumulated the highest concentrations of MEBCD. These results provided a basis for the potental therapeutic application of MEBCD in cancer therapy.

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“…It has been postulated that CDs complex guest molecules based on their chiral isomerism as well as positional isomerism (Janini et al 1996). Thus, they are now being used in chromatography as stationary phases bonded to a solid support or as mobile phase additives to separate isomers (Bressolle et al 1996;Knoche et al 1996). Thus, structural differences between cholesterol and its oxidized cousin 7KC may be responsible for the discrepancy in ef ux.…”

Section: Cyclodextrins and Cholesterol Effluxmentioning

confidence: 99%