Cyclodextrins and emulsions

Duchêne, Dominique; Bochot, Amélie; Yu, Shan-Chen; Pépin, Céline; Seiller, M.

doi:10.1016/s0378-5173(03)00384-3

Cited by 82 publications

(57 citation statements)

References 13 publications

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“…Structurally, they have a hydrophilic outer surface and a lipophilic central cavity where apolar drugs can be included (146,147). Cyclodextrins are used as complexing agents to improve nasal drug absorption by increasing drug solubility and stability.…”

Section: Cyclodextrinsmentioning

confidence: 99%

Intranasal Drug Delivery: How, Why and What for?

2009

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Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs is increased. Since the nasal mucosa offers numerous benefits as a target tissue for drug delivery, a wide variety of therapeutic compounds may be administered intranasally for topic, systemic and central nervous system action. We have, herein, outlined the relevant aspects of nasal anatomy, physiology and histology, and the biological, physicochemical and pharmaceutical factors that must be considered during the process of discovery and development of nasal drugs as well as in their incorporation into appropriate nasal pharmaceutical formulations. _______________________________________________________________________________________

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Section: Cyclodextrinsmentioning

confidence: 99%

Intranasal Drug Delivery: How, Why and What for?

2009

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“…Cyclodextrins (CDs) represents a family of cyclic a-(1-4)-linked oligosaccharides composed of a-d-glucopyranose subunits (Loftsson & Brewster, 1996;Duchêne et al, 2003;Loftsson & Duchêne, 2007;Sharma & Baldi, 2014). Natural CDs are obtained from enzymatic degradation of starch using amylase excreted by Bacillus macerans to form a mixture of six-, seven-and eight-member cyclic oligosaccharides rings corresponding to a-CD, b-CD and g-CD, respectively (Duchêne et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Natural CDs are obtained from enzymatic degradation of starch using amylase excreted by Bacillus macerans to form a mixture of six-, seven-and eight-member cyclic oligosaccharides rings corresponding to a-CD, b-CD and g-CD, respectively (Duchêne et al, 2003). Natural CDs have rather limited aqueous solubility, especially b-CD, due to binding of CD molecules in the crystal state and formation of intra-molecular hydrogen bond within the CD molecule, averting hydrogen bond formation with water molecules (Coleman et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

“…In the current era of nanoparticulate delivery systems, CDs are widely employed in formulating nanoparticles (Kanwar et al, 2011;Perret et al, 2013) and liposomes (Ascenso, 2013;Chen et al, 2014) to enhance drug solubility, stability and loading. Further, CDs have been explored as a stabilizer for emulsions and multiple emulsions (Duchêne et al, 2003;Yu et al, 2003;Mathapa & Paunov, 2013). Formation of a partial inclusion complex between CDs and certain lipophilic guest molecules can convert them from normal oligosaccharides to surfactant-like molecules with more diverse properties (Messner et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Formation of a partial inclusion complex between CDs and certain lipophilic guest molecules can convert them from normal oligosaccharides to surfactant-like molecules with more diverse properties (Messner et al, 2010). In this context, the stabilization of emulsions by CDs is credited to the formation of in situ surface-active agents from the interactions between triglycerides (TGs) or fatty acids (FAs) in oil phase with CDs comprising of a hydrophilic CD molecule with the hydrophobic FA residue protruding from it (Duchêne et al, 2003). In, 2007, Bochot et al and Trichard et al took advantage of this interesting interaction between CDs and TGs to presented a new self-aggregate particulate system known as ''beads'' prepared by mixing CDs aqueous solution with certain oils Trichard et al, 2007Trichard et al, , 2011.…”

Section: Introductionmentioning

confidence: 99%

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Insights on novel particulate self-assembled drug delivery beads based on partial inclusion complexes between triglycerides and cyclodextrins

Aburahma

2014

Drug Delivery

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Most of the newly designed drug molecules are lipophilic in nature and often encounter erratic absorption and low bioavailability after oral administration. Finding ways to enhance the absorption and bioavailability of these lipophilic drugs is one of the major challenges that face pharmaceutical industry nowadays. In view of that, the purpose of this review is to shed some light on a novel particulate self-assembling system named ''beads'' than can act as a safe carrier for delivering lipophilic drugs. The beads are prepared simply by mixing oils with cyclodextrin (CD) aqueous solution in mild conditions. A unique interaction between oil components and CD molecules occurs to form in situ surface-active complexes which are prerequisites for beads formation. This review mainly focuses on the fundamentals of beads preparation through reviewing present, yet scarce, literature. The key methods used for beads characterization are discussed in details. Also, the potential mechanisms by which beads increase the bioavailability of lipophilic drugs are illustrated. Finally, the related research areas that needs to be addressed in future for optimizing this promising delivery system are briefly outlined.

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Applications of Cyclodextrins for Skin Formulation and Delivery

Piel

Bochot

2011

Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine

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Cyclodextrins and emulsions

Cited by 82 publications

References 13 publications

Intranasal Drug Delivery: How, Why and What for?

Intranasal Drug Delivery: How, Why and What for?

Insights on novel particulate self-assembled drug delivery beads based on partial inclusion complexes between triglycerides and cyclodextrins

Applications of Cyclodextrins for Skin Formulation and Delivery

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