Cyclodextrin nanosponge-based systems in drug delivery and nanotherapeutics

Osmani, Riyaz Ali M.; Kulkarni, Parthasarathi K.; Manjunatha, S. S.; Vaghela, Rudra; Bhosale, Rohit R.

doi:10.1016/b978-0-12-813663-8.00016-6

Cited by 20 publications

(16 citation statements)

References 158 publications

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“…CyD polymers can be chemically modified introducing new properties useful for their application in the biological systems, such as targeting units, chelating units or fluorescence moieties …”

Section: Introductionmentioning

confidence: 99%

Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

2019

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Some nanotherapeutics based on cyclodextrin polymers are currently undergoing clinical trials. In light of this interest, we synthesized new linear polymers based on β‐cyclodextrins containing targeting units, such as biotin or arginine, to explore the advantage of functionalization for drug delivery. The polymers increased doxorubicin solubility. Furthermore, they slightly enhanced doxorubicin cytotoxicity in A2780 cells. In particular, the polymer containing arginine moieties was the most effective system by increasing doxorubicin cytotoxicity by 50%.

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Section: Introductionmentioning

confidence: 99%

Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

2019

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“…Different types of phytochemical bioactive compounds such as resveratrol, curcumin, quercetin, rutin, oryzanol, chlorogenic acid, etc. have been encapsulated in cyclodextrin nanosponges ( Kumar et al., 2018 ; Osmani et al., 2018 ; Pawar et al., 2019 ). A study by Ramírez-Ambrosi et al.…”

Section: Innovative Technology For Mycotoxin Detoxificationmentioning

confidence: 99%

The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins

Makhuvele

Naidu

Gbashi

et al. 2020

Heliyon

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Mycotoxins present a great concern to food safety and security due to their adverse health and socio-economic impacts. The necessity to formulate novel strategies that can mitigate the economic and health effects associated with mycotoxin contamination of food and feed commodities without any impact on public health, quality and nutritional value of food and feed, economy and trade industry become imperative. Various strategies have been adopted to mitigate mycotoxin contamination but often fall short of the required efficacy. One of the promising approaches is the use of bioactive plant components/metabolites synergistically with mycotoxin-absorbing components in order to limit exposure to these toxins and associated negative health effects. In particular, is the fabrication of β-cyclodextrin-based nanosponges encapsulated with bioactive compounds of plant origin to inhibit toxigenic fungi and decontaminate mycotoxins in food and feed without leaving any health and environmental hazard to the consumers. The present paper reviews the use of botanicals extracts and their phytochemicals coupled with β-cyclodextrin-based nanosponge technology to inhibit toxigenic fungal invasion and detoxify mycotoxins.

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“…It can also be interpreted that the particle size of the placebo NPS was 273.7nm, whereas particle size of NPs loaded with clotrimazole and nystatin were found to be 1847 & 501 as shown inTable 1 It is noted that an increase in the particle size was obtained in clotrimazole optimal formulation than NYS Figure 3andFigure 4. Increased particle size obtained because of the nature of drug and physical form of the drug used in formulation (Osmani et al, 2018).…”

Section: Particle Size Before Centrifugationmentioning

confidence: 99%

Formulation and evaluation of antifungal agent in a hydrogel containing nanoparticle of low molecular weight chitosan

Deekshitha

Saraf

Kulkarni

et al. 2020

ijrps

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The research aimed to formulate and prepare hydrogel of low molecular weight chitosan nanoparticles with the help of antifungal agents such as clotrimazole and Nystatin for the topical application. Using the ionic gelation process, placebo and nanoparticles containing drugs were prepared. By cationic interaction is suitable for pH, and gel sodium tripolyphosphate is used as a crosslinker which cross-links the chitosan particles to form the gel, interaction between drug and polymer was observed during the formulation development. Formulated nanoparticle with chitosan and nystatin and clotrimazole showed the mean diameter 273.7nm, 983nm, and 501nm. Clotrimazole and Nystatin had encapsulation capacity was about 74.6% and 63.0%, respectively. In vitro drug release at pH 4.7 chitosan molecules are examined for the version of clotrimazole and nystatin.it has noticed that both the formulation shows sustained drug release about 12 hours. Using SEM, nanoparticles are directed for surface morphology character; it shows that nanoparticles are smooth and spherical in structure. Chitosan itself has the antimicrobial property; it was carried out for the antifungal activity against the fungus Candida Albicans along with the prepared formulations drugs for the comparative study. And the result showed that clotrimazole had maximum fungal growth inhibition next followed by the nystatin and chitosan is least. This inhibitory effect was due to the parameter such as zeta potential and particle size of chitosan nanoparticles. And it shows the least antifungal activity of nanoparticles, which are formulated from the TMC. Hence CTZ and Chitosan were formulated and applied as a natural antifungal agent into nanoparticle to increase the fungal activity. According to the ICH Q1A (R2) guidelines, stability studies are conducted to prove no degradation of the drug. The prepared formulation of chitosan nanoparticles based hydrogel incorporated with clotrimazole and nystatin are promising and significant properties for the efficient treatment of topical fungal infections

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Cyclodextrin nanosponge-based systems in drug delivery and nanotherapeutics

Cited by 20 publications

References 158 publications

Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins

Formulation and evaluation of antifungal agent in a hydrogel containing nanoparticle of low molecular weight chitosan

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